Asparagus recemosus enhances memory and protects against amnesia in rodent models

Ojha, Rakesh; Sahu, Alakh N.; Muruganandam, A. V.; Singh, Gireesh Kumar; Krishnamurthy, Sairam

doi:10.1016/j.bandc.2010.05.009

Cited by 74 publications

(37 citation statements)

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“…In Ayurveda, Asparagus racemosus has been used extensively as an adaptogen to increase the nonspecific resistance of organisms against a variety of stresses (Visavadiya et al, 2009;Wiboonpun et al, 2004). Besides use in the treatment of diarrhoea and dysentery, the plant also has antioxidant, immunestimulant, anti-dyspepsia and anti-tussive effects (Visavadiya et al, 2009;Wiboonpun et al, 2004;Kamat et al, 2000;Ojha et al, 2010;Gautam et al, 2009;Mandal et al, 2000).…”

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confidence: 99%

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

et al. 2012

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This attempt is made to address the phytoconstituents, free radical scavenging activity and brine shrimp lethality bioassay of five different extracts of Asparagus racemosus roots. Preliminary phytochemical examination of the crude extracts of Asparagus racemosus root disclosed the existence of different sort of chemical groups such as flavonoids, tannin, saponin, alkaloids, carbohydrate. The root displayed significant DPPH free radical scavenging activity with highest IC50 value showed by ethanol extract with a value of 78.15 µg/ml followed by methanol and petroleum ether having value of 106.44 µg/ml and 273.31 µg/ml respectively as opposed to that of the scavenging effects of ascorbic acid and BHT of 5.698 µg/ml and 8.816 µg/ml respectively. The highest reducing power was showed by ethanol extract followed by methanol and petroleum ether as opposed to that of the reducing potential of ascorbic acid and BHT. The fractions represented good cupric reducing capacity with increasing concentration taking ethanol extract in the top position. The ethanol extract yielded 108.78±2.77 mg/gm gallic acid equivalent phenolic content and methanol sub-fraction yielded 164.77±1.73 mg/gm quercetin equivalent flavonoid content that was highest among five extracts. Ethanol extract of Asparagus racemosus was found to possess the highest total antioxidant capacity (639.925±64.78) mg/gm followed by methanol (616.92±53.88) mg/gm and petroleum ether (469.17±52.95) mg/gm ascorbic acid equivalent respectively. In brine shrimp lethality bioassay, LC50 values for ethanol, methanol, petroleum ether, n-hexane and chloroform were found to be 0.674 µg/ml, 0.719 µg/ml, 0.984 µg/ml, 2.157µg/ml and 1.514 µg/ml respectively. N-hexane and chloroform extract showed least activity in all the measures. The results suggest that Asparagus racemosus is a valuable source of antioxidant and has significant cytotoxic activity hence could eliminate many diseases related to free radical.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11615 International Current Pharmaceutical Journal 2012, 1(9): 250-257

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Section: Introductionmentioning

confidence: 99%

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

et al. 2012

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“…Experiment The animals of pure drug (MH) and test groups (MHNP and cMHNP) were sacrificed by decapitation at five different time intervals (1,2,8,16,24 h, respectively) after administration of initial dose at zero hr. Blood samples were collected in heparinized tubes and centrifuged to collect the plasma and stored at −20°C.…”

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“…Blood samples were collected in heparinized tubes and centrifuged to collect the plasma and stored at −20°C. 15,16) The brain, liver, lungs, spleen, kidneys, and heart were quickly removed and weighed. The removed tissues/organs were properly washed (at least thrice) with phosphate buffer to remove excess surface blood so as to eliminate false positive results and were stored at −20°C until further processing.…”

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Formulation, Optimization, <i>in Vivo</i> Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake

Nagpal

Singh

Mishra

2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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The minocycline hydrochloride (MH), at higher doses, is useful in the treatment of neurodegenerative disorders and owing to its antioxidant potential, it may have nootropic effects. MH loaded nanoparticles (MHNP) were coated with tween 80 (cMHNP) to improve its brain uptake followed by their optimization employing two factor-three level (3 2 ) central composite design (CCD) in order to minimize particle size and maximize drug entrapment efficiency (DEE) and validated. The optimized formulations were further subjected to in vitro drug release study; in vivo biodistribution studies in male wistar rats. The pharmacodynamic study was carried out using elevated plus maze (EPM) and Morris water maze (MWM) behavioral models for nootropic activity in swiss albino mice; and biochemical estimations (acetylcholine esterase, reduced glutathione, malondialdehyde and brain nitrite level). After intravenous (i.v.) administration, the concentration of MH in brain of cMHNP (6.21±0.64 µg/mL) treated rats was significantly higher with MH solution treated (0.70±0.06 µg/mL) as well as MHNP (1.03±0.12 µg/mL) treated animals. Pharmacodynamic studies revealed a significant improvement in memory of MH, MHNP and cMHNP treated swiss albino mice than saline treated control group. However, cMHNP revealed maximum decrease in transfer latency (TL) in EPM and maximum increase in time spent in target quadrant (TSTQ) in MWM. Although cMHNP did not produce significant change in brain acetylcholinesterase, but, significantly increased reduced glutathione, malondialdehyde and reduced brain nitrite level as compared to saline, MH solution and MHNP treated groups. The results suggest that cMHNP is a promising candidate for improved brain uptake of MH with better no o tro pic effect.

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Shatavari

2015

Phytopharmacy

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Asparagus recemosus enhances memory and protects against amnesia in rodent models

Cited by 74 publications

References 61 publications

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract

Formulation, Optimization, <i>in Vivo</i> Pharmacokinetic, Behavioral and Biochemical Estimations of Minocycline Loaded Chitosan Nanoparticles for Enhanced Brain Uptake

Shatavari

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