Aspectos clínicos de la hidradenitis supurativa y de la enfermedad de Crohn: ¿qué hay en común?

Rull, E. Vilarrasa; Lama, Y. González

doi:10.1016/s0001-7310(17)30005-4

Cited by 8 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monogenic autoinflammatory syndromes manifest in both HS and other inflammatory disorders such as pyoderma gangrenosum and inflammatory arthropathies including the PASH and PAPASH syndromes . HS also has a strong epidemiological association with IBD . The coexistence of these conditions implies a possible degree of commonality in their pathogenesis.…”

Section: Common Mesenchymal Pathways May Explain the Association Of Pmentioning

confidence: 99%

Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa

Frew

Navrazhina

Marohn

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

The precise pathogenic mechanisms in the development, persistence and worsening of hidradenitis suppurativa (HS) remain ill-defined. This chronic inflammatory dermatosis displays a strong Th1 and Th17 inflammatory signature with elevated levels of TNF-α, IL-1β, IL-17 and IFNγ in lesional and perilesional tissue. HS significantly differs to other chronic inflammatory dermatoses due to the development of hypertrophic scarring and dermal tunnels. The development of scarring and tunnels suggests that fibroblastic stromal cells (including myofibroblasts, fibroblasts, pericytes etc) may be involved in the development and progression of disease. Heterogeneous populations of fibroblasts have been identified in other inflammatory disorders and malignancy which contribute to inflammation and present novel therapeutic targets for fibrotic disorders. Findings in HS are consistent with these fibroblast subpopulations and may contribute to tunnel formation, aggressive squamous cell carcinoma and the phenotypic presentation of familial HS variants. We describe the existing knowledge regarding these mechanistic pathways and methods to confirm their involvement in the pathogenesis of HS. K E Y W O R D S acne inversa, fibroblasts, hidradenitis suppurativa, pathogenesis, scarring | 887 FREW Et al.

show abstract

Section: Common Mesenchymal Pathways May Explain the Association Of Pmentioning

confidence: 99%

Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa

Frew

Navrazhina

Marohn

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…HS and CD share many characteristics, and the two diseases can be associated in the same patient ( 7 ). The prevalence of HS in CD patients is 12.4%–17.9%, while the prevalence of CD in HS patients is around 3%.…”

Section: Discussionmentioning

confidence: 99%

“…Isolated perineal CD is unusual, diagnosis can be difficult, and distinction from HS is a challenge for the gastroenterologist (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Differential Diagnosis Between Perianal Crohn’s Disease and Hidradenitis Suppurativa: A Challenging Teamwork

et al. 2021

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a rare, debilitating skin disease characterized by the presence of recurrent tender subcutaneous nodules that develop into abscesses and fistulae. Isolated perineal Crohn's disease (CD) is unusual, diagnosis can be difficult, and distinction from HS is a challenge for the gastroenterologist. The aim of this work was to determine the criteria that distinguish perineal CD from perineal HS. Four patients with isolated perineal CD and three with perineal HS were included. Rectal or skin biopsies of all CD patients showed granulomas. No granulomas were found for HS. Fistulae were present in 4/4 CD, extended to the anal canal. All patients with HS had gluteal abscesses. They were bilateral in all cases, superficial. Perineal lesions management should involve a multidisciplinary approach in order to make an accurate diagnosis and ultimately to give the best and most effective treatment.

show abstract

“…22,23 Anti-TNF-α biologics are frequently used in the management of both conditions and IBD patients with comorbid HS are more likely to require biologic treatment to achieve disease control. 25…”

Section: Comorbidities Associated With Hsmentioning

confidence: 99%

Practical Guidelines for Managing Patients With Hidradenitis Suppurativa: An Update

et al. 2022

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease that is characterized by the formation of comedones, papules, nodules, abscesses and sinus tracts in the axillary, inframammary, groin, and gluteal areas. Up to 3.8% of the Canadian population has HS, though due to a lack of awareness of HS, many patients are initially misdiagnosed and do not receive adequate treatment early on in the disease course. Once a diagnosis of HS is made, developing an effective management plan can be a dilemma for many providers. There is significant variability in response to any given therapy within the HS patient population and many HS patients have other medical comorbidities which must be taken into consideration. The aim of this review is to provide a practical approach for all healthcare providers to diagnose and manage HS and its associated comorbidities. A sample electronic medical record template for HS management was developed by the Canadian Hidradenitis Suppurativa Foundation Executive Board and is intended for use in clinical settings. This will help to increase collaboration between primary healthcare providers, dermatologists, and other medical specialists and ultimately improve the quality of care that HS patients receive.

show abstract

Aspectos clínicos de la hidradenitis supurativa y de la enfermedad de Crohn: ¿qué hay en común?

Cited by 8 publications

References 0 publications

Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa

Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa

Differential Diagnosis Between Perianal Crohn’s Disease and Hidradenitis Suppurativa: A Challenging Teamwork

Practical Guidelines for Managing Patients With Hidradenitis Suppurativa: An Update

Contact Info

Product

Resources

About