Modern conditions in Ukraine require a rethinking of approaches to the formation of rights, restrictions, responsibilities, real estate accounting, and assessment of factors influencing these processes. Therefore, the article aims to identify the factors affecting the formation and use of the multi‐purpose cadaster as a multi‐level information system, which allows it to form a systemic environment and develop the theoretical and methodological foundations of the territorial development of regions. As a result, it is established that the multi‐purpose cadaster is a modern information system that forms the basis for the implementation of the European land administration system, provides land and real estate management, taking into account spatial, urban, environmental, and investment factors, and the level of stakeholder interaction at the regional level. Finally, the relevance of the research consists in the fact that military actions, the consequences of the COVID‐19 pandemic, deforming economic transformations, imbalances in regional ties, and social imbalances have a negative impact. In such conditions, the development and implementation of a multi‐purpose cadaster at the regional level are of particular importance, taking into account the impact of spatial, urban, environmental, and investment factors and European experience in implementing land relations.