Aspirin as a therapeutic agent in cardiovascular disease. Special Writing Group.

Fuster, Valentı́n; Dyken, Mark L.; Vokonas, Pantel; Hennekens, Charles H.

doi:10.1161/01.cir.87.2.659

Cited by 204 publications

(80 citation statements)

References 170 publications

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“…In 1993, the American Heart Association (AHA) officially recommended use of aspirin as a therapeutic agent for the prevention of cardiovascular disease. 25 We noted an increase in aspirin use from 10.8% in the 1992 study by Tofler recent studies have demonstrated that clock genes in human cardiac tissue display significant time-dependent transcriptional variation with peak expression of some clock genes and trough expression of others coinciding with myocardial incidents. 43 Morning hours may also represent nadir levels of some cardioprotective medications.…”

Section: Discussionmentioning

confidence: 74%

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Kanth

Ittaman

Rezkalla

2013

Clinical Medicine & Research

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Objective: Nearly four decades ago, a circadian pattern of acute myocardial infarction (AMI) with a peak in the early morning waking hours was described. The goal of the present study was to determine whether major changes in lifestyle and significant advances in medical therapy have altered this pattern in the intervening years. Design: Retrospective chart review.Setting: Tertiary care hospital in central Wisconsin. Methods:We examined circadian patterns of ST elevation myocardial infarction (STEMI) in 519 patients diagnosed with STEMI over a 5-year period. Time of symptom onset was obtained from patient self-reports in the medical record and was recorded over 24 hours. Results:We observed a circadian pattern of STEMI occurrence with a morning peak at approximately 11:30 AM. This pattern was highly significant in patients who were not using beta-blockers (P <0.0001) and had no history of diabetes (P <0.0001), but was otherwise absent. The circadian pattern appeared to be attenuated in patients of a younger age, female gender, or who used statins or aspirin. Peak STEMI occurrence was earlier in smokers than non-smokers.Conclusions: Despite significant lifestyle changes and medical advances in the nearly four decades since a circadian pattern of AMI occurrence was first described, patients with STEMI had a circadian pattern of symptom onset with a morning peak. Use of beta-blockers and a history of diabetes mellitus abolished this pattern. Other modifying factors, including medications, age, and gender attenuated, but did not abolish, the circadian pattern.

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Section: Discussionmentioning

confidence: 74%

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Kanth

Ittaman

Rezkalla

2013

Clinical Medicine & Research

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“…ASA prevents thrombus formation and has an antiplatelet effect, which might prevent stenosis in the previously grafted vessels [5]. Additionally, this drug has anti-inflammatory properties [6].…”

Section: Introductionmentioning

confidence: 99%

Trends in pharmacological therapy of patients referred for coronary artery bypass grafting between 2004 and 2008: a single-centre study

Szychta¹,

Majstrak²,

Opolski³

et al. 2015

Kardiol Pol

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“…4,5 Over 30 years of experience has accrued with the use of aspirin after cardiac surgery, and essentially all patients undergoing CABG are candidates for long-term aspirin therapy. 6 Aspirin inhibition of platelet function after CABG helps maintain graft patency and prevent major adverse cardiovascular events.…”

mentioning

confidence: 99%