Aspirin Formulation and Absorption Rate I

Aspirin Formulation and Absorption Rate II

“…It is apparent that the distribution of salicylate levels at 10 minutes with the antacid combination is similar to that of 20 minutes with plaii aspirin. The agreement is closer than for the pairs of repeats studied in the previous paper (1). The presence of the antacid has shifted the whole population, not just a small portion of it.…”

“…HE PREVIOUS paper in this series (1) has Testablished criteria for the sensitivity, reproducibility, and range of applicability of a human panel to assess serum salicylate levels accurately after ingestion. It is now possible to apply the human panel to a study of factors involved when aspirin is absorbed from tablets or solutions.…”

“…Since 10-and 20-minute data for D and E were available from panel I, L was run separately for these two times. In addition, values for E as EA and ER are also available in the previous paper (1).…”

Plasma salicylate levels after soluble and effervescent aspirin.

“…The individual variability of salicylate absorption has been well documented (Lieberman, Kraus, Murray & Wood, 1964) and small differences between different formulations tend to be obscured unless large numbers of subjects are studied. However, from the observed variation of a particular panel of subjects the least significant difference (LSD) for that panel can be calculated.…”