2014
DOI: 10.3389/fnagi.2014.00007
|View full text |Cite
|
Sign up to set email alerts
|

Aspirin Promotes Oligodendrocyte Precursor Cell Proliferation and Differentiation after White Matter Lesion

Abstract: Cerebral white matter lesion (WML) is one of the main causes for cognitive impairment and is often caused by chronic cerebral hypoperfusion. A line of evidence has shown that aspirin has neuroprotective effects and produces some benefits in long-term outcome and survival for ischemic stroke patients. However, whether aspirin exerts a protective effect against WML is still largely unknown. Here, we showed that aspirin could promote oligodendrocyte precursor cell (OPC) proliferation and differentiation into olig… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

3
34
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 40 publications
(37 citation statements)
references
References 45 publications
(53 reference statements)
3
34
0
Order By: Relevance
“…Thus, relatively high or even toxic concentrations of ASA may alter conclusions regarding its effects on oligodendroglial lineage. Since our ASA concentrations were much lower, this may explain why we have not observed the reported increase of Erk activation induced by ASA [16]. The discrepancies between observed results using different doses suggest a possibility that the enhancement of MAP kinase (including Erk) activation induced by ASA found in the previous study [16] may actually relate to a cytotoxic effect of high dose ASA.…”
Section: Discussionmentioning
confidence: 53%
See 4 more Smart Citations
“…Thus, relatively high or even toxic concentrations of ASA may alter conclusions regarding its effects on oligodendroglial lineage. Since our ASA concentrations were much lower, this may explain why we have not observed the reported increase of Erk activation induced by ASA [16]. The discrepancies between observed results using different doses suggest a possibility that the enhancement of MAP kinase (including Erk) activation induced by ASA found in the previous study [16] may actually relate to a cytotoxic effect of high dose ASA.…”
Section: Discussionmentioning
confidence: 53%
“…More importantly, compared to the presenting study, it should be noted that a relatively high dosage of ASA was applied in Chen's study. We encountered cytotoxic effects on OPC cultures when ASA treatment reached 10 μM (the concentration used in the reported study [16]). Thus, relatively high or even toxic concentrations of ASA may alter conclusions regarding its effects on oligodendroglial lineage.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations