Aspirochlorine: A Highly Selective and Potent Inhibitor of Fungal Protein Synthesis.

Monti, Federica; Ripamonti, Franca; Hawser, Stephen; Islam, Khalid

doi:10.7164/antibiotics.52.311

Cited by 36 publications

(23 citation statements)

References 18 publications

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“…Being heat stable, the compounds in the filtrate could inhibit candidal biofilm development in febrile states also. Similar inhibition of Candidal biofilm in vitro has been shown by using Pyocyanin obtained from Pseudomonas aeruginosa [22].These findings could show the path of discovering new, cost-effective strategies to prevent disease pathology in invasive candidiasis.…”

Section: Discussionsupporting

confidence: 71%

In-vitro Inhibition of Biofilm Formation in Candida albicans and Candida tropicalis by Heat Stable Compounds in Culture Filtrate of Aspergillus flavus

Bhattacharyya

Gupta²,

Banerjee³

et al. 2013

JCDR

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Section: Discussionsupporting

confidence: 71%

In-vitro Inhibition of Biofilm Formation in Candida albicans and Candida tropicalis by Heat Stable Compounds in Culture Filtrate of Aspergillus flavus

Bhattacharyya

Gupta²,

Banerjee³

et al. 2013

JCDR

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“…Gliotoxin seems to be only produced in high amounts by species in section Fumigati in Aspergillus. However, the other species produce biosynthetically closely related epidithiodioxopiperazines: A. flavus, A. oryzae and A. tamarii can produce aspirochlorine = oryzachlorin (Berg et al 1976;Sakata et al 1982;Monti et al 1999;Chankhamjon et al 2014), A. terreus can produce acetylaranotin (Miller et al 1968;Cosulich et al 1968;Guo et al 2013) and A. striatus and six other species in section Nidulantes can produce emestrin (Seya et al 1985;Terao et al 1990;Kawahara et al 1994;Ooike et al 1997) (Fig. 11).…”

Section: Analogous Secondary Metabolites Are Produced In Different Sementioning

confidence: 96%

Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

114

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Isolates of Aspergillus species are able to produce a large number of secondary metabolites. The profiles of biosynthetic families of secondary metabolites are species specific, whereas individual secondary metabolite families can occur in other species, even those phylogenetically and ecologically unrelated to Aspergillus. Furthermore, there is a high degree of chemo-consistency from isolate to isolate in a species even though certain metabolite gene clusters are silenced in some isolates. Genome sequencing projects have shown that the diversity of secondary metabolites is much larger in each species than previously thought. The potential of finding even further new bioactive drug candidates in Aspergillus is evident, despite the fact that many secondary metabolites have already been structure elucidated and chemotaxonomic studies have shown that many new secondary metabolites have yet to be characterized. The genus Aspergillus is cladistically holophyletic but phenotypically polythetic and very diverse and is associated to quite different sexual states. Following the one fungus one name system, the genus Aspergillus is restricted to a holophyletic clade that include the morphologically different genera Aspergillus, Dichotomomyces, Phialosimplex, Polypaecilum and Cristaspora. Secondary metabolites common between the subgenera and sections of Aspergillus are surprisingly few, but many metabolites are common to a majority of species within the sections. We call small molecule extrolites in the same biosynthetic family isoextrolites. However, it appears that secondary metabolites from one Aspergillus section have analogous metabolites in other sections (here also called heteroisoextrolites). In this review, we give a genus-wide overview of secondary metabolite production in Aspergillus species. Extrolites appear to have evolved because of ecological challenges rather than being inherited from ancestral species, at least when comparing the species in the different sections of Aspergillus. Within the Aspergillus sections, secondary metabolite pathways seem to inherit from ancestral species, but the profiles of these secondary metabolites are shaped by the biotic and abiotic environment. We hypothesize that many new and unique section-specific small molecule extrolites in each of the Aspergillus will be discovered.

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“…Additional metabolites previously reported from A. oryzae are asperfuran [13], sporogen AO1 [14,15], maltoryzine [16], and aspergillomarasmine A [17,18]. Aspirochlorine has been found in A. flavus , A. oryzae and A. tamarii [19,20,21,22,23] (Figure 1). For reviews on the safety and taxonomy of A. oryzae , see [7,24,25,26].…”

Section: Introductionmentioning

confidence: 96%

Comparative Chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357)

et al. 2012

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Aspergillus oryzae and A. flavus are important species in industrial biotechnology and food safety and have been some of the first aspergilli to be fully genome sequenced. Bioinformatic analysis has revealed 99.5% gene homology between the two species pointing towards a large coherence in the secondary metabolite production. In this study we report on the first comparison of secondary metabolite production between the full genome sequenced strains of A. oryzae (RIB40) and A. flavus (NRRL 3357). Surprisingly, the overall chemical profiles of the two strains were mostly very different across 15 growth conditions. Contrary to previous studies we found the aflatrem precursor 13-desoxypaxilline to be a major metabolite from A. oryzae under certain growth conditions. For the first time, we additionally report A. oryzae to produce parasiticolide A and two new analogues hereof, along with four new alkaloids related to the A. flavus metabolites ditryptophenalines and miyakamides. Generally the secondary metabolite capability of A. oryzae presents several novel end products likely to result from the domestication process from A. flavus.

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Aspirochlorine: A Highly Selective and Potent Inhibitor of Fungal Protein Synthesis.

Cited by 36 publications

References 18 publications

In-vitro Inhibition of Biofilm Formation in Candida albicans and Candida tropicalis by Heat Stable Compounds in Culture Filtrate of Aspergillus flavus

In-vitro Inhibition of Biofilm Formation in Candida albicans and Candida tropicalis by Heat Stable Compounds in Culture Filtrate of Aspergillus flavus

Chemodiversity in the genus Aspergillus

Comparative Chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357)

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