Assembling different antennas of the gp120 high mannose-type glycans on gold nanoparticles provides superior binding to the anti-HIV antibody 2G12 than the individual antennas

Chiodo, Fabrizio; Enríquez-Navas, Pedro M.; Angulo, Jesús; Marradi, Marco; Penadés, Soledad

doi:10.1016/j.carres.2014.07.012

Cited by 30 publications

(22 citation statements)

References 39 publications

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“…163 In addition, GNPs are being used in the development of experimental vaccines against tumors 164–170 and HIV/AIDS. 171–173 In 2011, Wang et al 174 suggested a new therapeutic vaccine based on the combination of myelin-associated inhibitors and GNPs for the treatment of rat medullispinal traumas. Also, for GNP-assisted antigens, several groups reported new administration ways: oral, pulmonary, transcutaneous and transmucosal immunization.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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“…163 In addition, GNPs are being used in the development of experimental vaccines against tumors [164][165][166][167][168][169][170] and HIV/AIDS. [171][172][173] In 2011, Wang et al 174 suggested a new therapeutic vaccine based on the combination of myelin-associated inhibitors and GNPs for the treatment of rat medullispinal traumas. Also, for GNP-assisted antigens, several groups reported new administration ways: oral, pulmonary, transcutaneous and transmucosal immunization.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

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“…Amongst all the inorganic nanoparticles, gold nanoparticles have gained maximum attention in vaccine delivery. These particles have been used for the epitope delivery against HIV [110] , influenza [111] , malaria [112] and tumor [113] . Effect of shape of gold nanovaccine on antibody production against WNV envelope E protein showed that rods induced only 50% of the antibody response as compared to spherical nanoparticles [114] .…”

Section: Inorganic-based Nanovaccinesmentioning

confidence: 99%