Assessing an imidazolium salt's performance as antifungal agent on a mouthwash formulation

Abstract

This study demonstrates a new and effective antibiofilm formulation containing the IMS C MImCl. These findings suggest the IMS' use as mouthwash formulations active ingredient against Candida biofilms on oral surfaces, as it outperforms the often used cetylpyridinium chloride at a 10 times lower concentration.

Alkylimidazolium Ionic Liquids as Antifungal Alternatives: Antibiofilm Activity Against Candida albicans and Underlying Mechanism of Action

“…(Schrekker et al, 2016). Using contaminated acrylic resin strip specimens, 1-n-hexadecyl-3-methylimidazolium chloride was demonstrated as a strong antifungal for mouthwash formulation (Bergamo et al, 2016). Although several studies have reported antifungal activity, effect of imidazolium ionic liquids on preformed fungal biofilms (biofilm eradication potential) is largely unknown ( Table 1).…”

Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride

“…The MIC range for dermatophytes was 0.39‐3.12 µg/mL and for yeast was 0.78‐1.56 µg/mL, reinforcing the data from the screening that this compound is actually active at very low concentrations. In other studies, the presence of chlorine in chemical structures investigated as to the antifungal application has already been verified as determinant for effective activity . Structurally, the position of the chlorine is important for improving the antifungal action, since the substitution at positions meta and para of the disubstituted molecule 2j was more advantageous (lower MICs) than the substitution at ortho and para positions as for 2i (Figure ).…”

“…In other studies, the presence of chlorine in chemical structures investigated as to the antifungal application has already been verified as determinant for effective activity. 37,[45][46][47] Structurally, the position of the chlorine is important for improving the antifungal action, since the substitution at positions meta and para of the disubstituted molecule 2j was more advantageous (lower MICs) than the substitution at ortho and para positions as for 2i (Figure 1). These with some compounds of the same class investigated in this study:…”

Novas tendências de combate ao biofilme de Candida em próteses dentárias

“…As adesinas são enzimas encontradas nos microrganismos que apresentam receptores específicos na película adquirida ou nas células epiteliais da boca 38,39 . Diversos são os sintomas clínicos relatados pelos pacientes: dor, halitose, prurido e percepção de queimação podem acontecer pelo fato de a C. albicans produzir exoenzimas, constituídas principalmente por proteinases que facilitam a adesão do biofilme, e também devido a fatores do hospedeiro, tais como redução do pH, do fluxo salivar e da microbiota oral 40 41,42 . Para as cepas de C. tropicalis e C. parapsilosis, é notória a presença de blastoconídios e pseudo-hifas.…”

“…Bergamo et al 40 Avaliação da atividade do miconazol em biofilmes maduros de Candida (C. albicans, C. glabrata, C. tropicalis e C. parapsilosis) in vitro formados em discos de PMMA.…”