Assessing cortical excitability with electroencephalography: A pilot study with EEG-iTBS

Pellegrino, Giovanni; Schuler, Anna-Lisa; Cai, Zhengchen; Marinazzo, Daniele; Tecchio, Franca; Ricci, Lorenzo; Tombini, Mario; Di Lazzaro, Vincenzo; Assenza, Giovanni

doi:10.1016/j.brs.2024.01.004

Cited by 8 publications

(2 citation statements)

References 74 publications

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“…Despite its biological and clinical relevance, E/I balance is rarely directly investigated in epilepsy, most likely because its estimation is difficult and time-consuming. Fortunately, recent developments offer a streamlined assessment of E/I balance, leveraging properties of spontaneous electromagnetic signals which can be easily measured with magneto- or electroencephalography at high spatial and temporal resolution, providing extensive brain coverage with potential translations in a clinical setting 11–14,15 (p2) . Amongst multiple signal features, the exponent of the aperiodic component of the M/EEG signal power spectrum provides information related to system E/I balance 16–18 .…”

Section: Introductionmentioning

confidence: 99%

Excitation/Inhibition balance relates to cognitive function and gene expression in Temporal Lobe Epilepsy: an hdEEG assessment with aperiodic exponent

Duma,

Cuozzo,

Wilson

et al. 2024

Preprint

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Patients with epilepsy are characterized by a dysregulation of excitation-inhibition balance (E/I). The assessment of E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure of the E/I of the brain represents a clinically relevant feature. Here we exploited the exponent of the aperiodic component of the power spectrum of EEG signal as a noninvasive and cost-effective proxy of the E/I balance. We recorded resting-state activity with high-density EEG from 65 patients with temporal lobe epilepsy (TLE) and 35 controls. We extracted the exponent of the aperiodic fit of the power spectrum from source-reconstructed EEG and tested differences between TLE and controls. Spearman correlation was performed between the exponent and clinical variables (age of onset, epilepsy duration and neuropsychology) and cortical expression of epilepsy-related genes derived from Human Allen Brain Atlas. Patients with TLE showed a significantly larger exponent, corresponding to an inhibition directed E/I balance, in bilateral frontal and temporal regions. Lower E/I in the left entorhinal, and bilateral dorsolateral prefrontal cortices corresponded to a lower performance of short term verbal memory. Limited to TLE, we detected a significant correlation between the exponent and the cortical expression of GABRA1, GRIN2A, GABRD, GABRG2, KCNA2and PDYN. EEG aperiodic exponent maps the E/I balance non-invasively in patients with epilepsy and reveals a tight relationship between altered E/I patterns, cognition and genetics.

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Section: Introductionmentioning

confidence: 99%

Excitation/Inhibition balance relates to cognitive function and gene expression in Temporal Lobe Epilepsy: an hdEEG assessment with aperiodic exponent

Duma,

Cuozzo,

Wilson

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fortunately, recent developments offer a streamlined assessment of E/I balance, leveraging properties of spontaneous electromagnetic signals which can be easily measured with magneto- or electroencephalography (EEG) at high spatial and temporal resolutions, providing extensive brain coverage with potential translations in a clinical setting. 11-14 , 15 Amongst multiple signal features, the exponent of the aperiodic component of the M/EEG signal power spectrum provides information related to system E/I balance. 16-18 …”

Section: Introductionmentioning

confidence: 99%

Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent

Duma,

Cuozzo,

Wilson

et al. 2024

Brain Communications

Self Cite

View full text Add to dashboard Cite

Patients with epilepsy are characterized by a dysregulation of excitation-inhibition balance (E/I). The assessment of E/I may inform clinicians during the diagnosis and therapy management, even though it is rarely performed. An accessible measure of the E/I of the brain represents a clinically relevant feature. Here, we exploited the exponent of the aperiodic component of the power spectrum of the electroencephalography (EEG) signal, as a noninvasive and cost-effective proxy of the E/I balance. We recorded resting-state activity with high-density EEG from 67 patients with temporal lobe epilepsy and 35 controls. We extracted the exponent of the aperiodic fit of the power spectrum from source-reconstructed EEG and tested differences between patients with epilepsy and controls. Spearman’s correlation was performed between the exponent and clinical variables (age of onset, epilepsy duration and neuropsychology) and cortical expression of epilepsy-related genes derived from the Allen Human Brain Atlas. Patients with temporal lobe epilepsy showed a significantly larger exponent, corresponding to inhibition-directed E/I balance, in bilateral frontal and temporal regions. Lower E/I in the left entorhinal and bilateral dorsolateral prefrontal cortices corresponded to a lower performance of short-term verbal memory. Limited to patients with temporal lobe epilepsy, we detected a significant correlation between the exponent and the cortical expression of GABRA1, GRIN2A, GABRD, GABRG2, KCNA2 and PDYN genes. EEG aperiodic exponent maps the E/I balance non-invasively in patients with epilepsy and reveals a close relationship between altered E/I patterns, cognition and genetics.

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The Neurophysiological Effects of Theta Burst Stimulation as Measured by Electroencephalography: A Systematic Review

Speranza,

Hill,

et al. 2024

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Assessing cortical excitability with electroencephalography: A pilot study with EEG-iTBS

Cited by 8 publications

References 74 publications

Excitation/Inhibition balance relates to cognitive function and gene expression in Temporal Lobe Epilepsy: an hdEEG assessment with aperiodic exponent

Excitation/Inhibition balance relates to cognitive function and gene expression in Temporal Lobe Epilepsy: an hdEEG assessment with aperiodic exponent

Excitation/Inhibition balance relates to cognitive function and gene expression in temporal lobe epilepsy: a high density EEG assessment with aperiodic exponent

The Neurophysiological Effects of Theta Burst Stimulation as Measured by Electroencephalography: A Systematic Review

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