“…Keywords: International Health Regulations, NAPHS process, Health security planning, Public health preparedness/ response, Cameroon Background C ountries need to continuously establish, develop, strengthen, and maintain their evidence-based capacities to prevent, prepare for, detect, notify, and respond to public health emergencies. This has been highlighted by lessons learned from Ebola virus disease, 1,2 Zika virus disease, 3 the COVID-19 4 pandemic, the monkeypox outbreak, 5 and other recent health emergencies. In Cameroon, major health emergencies have been driven by outbreaks of measles, wild type poliovirus, cholera, avian influenza, monkeypox, and COVID-19.…”