Assessing ICSI outcome by combining non‐invasive indicators: Early time‐lapse morphokinetics and apoptosis in associated cumulus cells among women with the polycystic ovarian syndrome

Tabibnejad, Nasim; Aflatoonian, Abbas; Motamedzadeh, Leila; Soleimani, Masoud; Sadeghian‐Nodoushan, Fatemeh; Talebi, Ali Reza

doi:10.1002/mrd.23044

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…It can be considered as a predictor of pregnancy and live birth, and the percentage of apoptotic CCs is an independent prognostic factor for these outcomes. For every 1% increase in CC apoptosis, the clinical pregnancy and live birth rates will decrease by 11–12% [ 102 ].…”

Section: Cumulus Cell Biomarkers and Pregnancy Outcomementioning

confidence: 99%

The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

Turathum

Gao

Chian

2021

Cells

161

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Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the distribution of location. CCs are supporting cells of the oocyte that protect the oocyte from the microenvironment, which helps oocyte growth and maturation in the follicles. Bi-directional communications between an oocyte and CCs are necessary for the oocyte for the acquisition of maturation and early embryonic developmental competence following fertilization. Follicle-stimulation hormone (FSH) and luteinizing hormone (LH) surges lead to the synthesis of an extracellular matrix in CCs, and CCs undergo expansion to assist meiotic resumption of the oocyte. The function of CCs is involved in the completion of oocyte meiotic maturation and ovulation, fertilization, and subsequent early embryo development. Therefore, understanding the function of CCs during follicular development may be helpful for predicting oocyte quality and subsequent embryonic development competence, as well as pregnancy outcomes in the field of reproductive medicine and assisted reproductive technology (ART) for infertility treatment.

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Section: Cumulus Cell Biomarkers and Pregnancy Outcomementioning

confidence: 99%

The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

Turathum

Gao

Chian

2021

Cells

161

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“…One study demonstrated that for every one percent increment in CC apoptosis, the clinical pregnancy and live birth rates will be decreased by 11-12% (73). There are many external as well as internal stimuli that promote this alteration, such as endocrine abnormalities, high levels of stress oxidative products, hyperandrogenic state, and imbalance of the LH/FSH ratio.…”

Section: Genes Related To Cumulus Expansion and Apoptosismentioning

confidence: 99%

PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality

2022

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The global infertility rate has been declining from year to year. PCOS is one of the treatable accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of treatments and live-birth outcomes especially involving assisted reproductive techniques is still not very promising. There is a reduction in the development potential of oocytes and high-quality embryos in PCOS patients compared to non-PCOS patients. A critical step in IVF treatment is the assessment of oocyte and embryo competence before embryo transfer. Oocytes in metaphase II are very fragile. Repeated morphological assessment on these oocytes may directly impair the quality and affect the whole process. Identification of potential biomarkers especially in the cumulus cells oocytes complex will help to predict the outcome and may create space for improvement. This review has explored gene expression in cumulus cells with regards to oocytes quality in both normal and PCOS women. The gene expression was classified according to their physiological function such as the contribution on cumulus expansion, cumulus cells apoptosis, and glucose metabolism. Collectively, the review suggested that positive expression of HAS2, PTX3, GREM1, and VCAN may correlate with good quality oocytes and can be used as an indicator among PCOS women.

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“…68,83 Furthermore, the level of GC apoptosis showed a negative correlation with pregnancy and live birth in PCOS patients, as every 1% elevation in the abundance of apoptotic GCs was associated with an 11%-12% decrease in the likelihood of successful pregnancy and live birth. 84…”

Section: Experimental Setting Species Pdcd4 Expression Cell Cycle Pro...mentioning

confidence: 99%

Programmed cell death 4: A novel player in the pathogenesis of polycystic ovary syndrome

Zarezadeh,

Abbasi,

Aboutalebi Vand Beilankouhi

et al. 2023

Cell Biochemistry & Function

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Polycystic ovary syndrome (PCOS) is a pathological condition recognized by menstrual cycle irregularities, androgen excess, and polycystic ovarian morphology, affecting a significant proportion of women of childbearing age and accounting for the most prevalent cause of anovulatory sterility. In addition, PCOS is frequently accompanied by metabolic and endocrine disturbances such as obesity, dyslipidemia, insulin resistance, and hyperinsulinemia, indicating the multiplicity of mechanisms implicated in the progression of PCOS. However, the exact pathogenesis of PCOS is yet to be elucidated. Programmed cell death 4 (PDCD4) is a ubiquitously expressed protein that contributes to the regulation of various cellular processes, including gene expression, cell cycle progression, proliferation, and apoptosis. Despite some disparities concerning its exact cellular effects, PDCD4 is generally characterized as a protein that inhibits cell cycle progression and proliferation and instead drives the cell into apoptosis. The apoptosis of granulosa cells (GCs) is speculated to take a major part in the occurrence and progression of PCOS by ceasing antral follicle development and compromising oocyte competence. Given the possible involvement of GC apoptosis in the progression of PCOS, as well as the contribution of PDCD4 to the regulation of cell apoptosis and the development of metabolic diseases, the current review aimed to discuss whether or how PDCD4 can play a role in the pathogenesis of PCOS by affecting GC apoptosis.

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Assessing ICSI outcome by combining non‐invasive indicators: Early time‐lapse morphokinetics and apoptosis in associated cumulus cells among women with the polycystic ovarian syndrome

Cited by 7 publications

References 40 publications

The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality

Programmed cell death 4: A novel player in the pathogenesis of polycystic ovary syndrome

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