The integration of behavioral science into conservation science and climate science has enabled the development of both novel research questions and practical interventions. However, most behavioral interventions aim to change private, individual behaviors, rather than transform the political economic systems that drive current biodiversity, climate, and social crises. In this paper, we argue that closer collaboration between behavioral scientists working on biodiversity and climate issues, on the one hand, and advocates for radical alternatives to current political economic systems, on the other, could advance such needed systemic transformation. While the work of both groups is subject to some critique, we suggest that closer collaboration could enable the strengths of each to address the others’ weaknesses. This complementarity is particularly true when behavioral interventions are co-designed with advocates and targeted towards powerful individuals whose behavior could affect systems-level transformation. We use the fossil fuel divestment movement as an illustrative example of one way in which this collaboration could be mutually beneficial, and then outline potential political, practical, and ethical implications that may accompany such collaborations in the biodiversity conservation and climate change fields.