Assessing memory deterioration with the wechsler memory scale, the national adult Reading Test, and the Schonell Graded Word Reading Test

Schlosser, Dieter; Ivison, David

doi:10.1080/01688638908400935

Cited by 30 publications

(20 citation statements)

References 16 publications

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“…Schlosser and Ivison (1989) reported that the test shows some sensitivity to early language impairment in AD. In our results, removing the AMNART from the PCA only adjusted the order the components appeared in the solution but left the components themselves untouched.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses

Chapman

Mapstone

Porsteinsson

et al. 2010

Journal of Clinical and Experimental Neuropsychology

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Neuropsychological assessment aids in the diagnosis of Alzheimer’s disease (AD) by objectively establishing cognitive impairment from standardized tests. We present new criteria for diagnosis that use weighted combined scores from multiple tests. Our method employs two multivariate analyses: Principal Components Analysis (PCA) and discriminant analysis. PCA (N = 216 subjects) created more interpretable cognitive dimensions by resolving 49 test measures in our neuropsychological battery to 13 component scores for each subject. The component scores were used to build discriminant functions that classified each participant as either an early-stage AD (N = 55) or normal elderly (N = 78). Our discriminant function performed with high accuracy, sensitivity, and specificity (nearly all >90%) in the development, a cross-validation, and a new subjects validation. When contrasted to two different traditional empirical methods for diagnosis (using cutscores and defining AD as falling below 5% on two or more test domains), our results suggested that the multivariate method was superior in classification (approximately 20% more accurate).

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Section: Resultsmentioning

confidence: 99%

Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses

Chapman

Mapstone

Porsteinsson

et al. 2010

Journal of Clinical and Experimental Neuropsychology

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“…The National Adult Reading Test (NART-IQ) was selected to be a surrogate measure for premorbid verbal IQ and full scale IQ of the WAIS-R NI (Crawford et al, 2001) and has been shown to be sensitive to AD-related language deterioration (Schlosser and Ivison, 1989). The NART-IQ also served as a covariate along with age in a number of the analyses.…”

Section: Methodsmentioning

confidence: 99%

Influences of hormone replacement therapy on olfactory and cognitive function in postmenopausal women

Doty

Tourbier

et al. 2015

Neurobiology of Aging

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Olfactory dysfunction can be an early sign of Alzheimer’s disease (AD). Since hormone replacement therapy (HRT) may protect against developing AD in postmenopausal women, the question arises as to whether it also protects against olfactory dysfunction in such women. Three olfactory and 12 neurocognitive tests were administered to 432 healthy postmenopausal women with varied HRT histories. Serum levels of reproductive hormones were obtained for all subjects; APOE-ε4 haplotype was determined for 77. National Adult Reading Test and Odor Memory/Discrimination Test (OMT) scores were positively influenced by HRT. Odor identification and OMT test scores were lower for women who scored poorly on a delayed recall test, a surrogate for mild cognitive impairment. WAIS-R NI Spatial Span Backwards Test scores were higher in women receiving estrogen plus progestin HRT and directly correlated with serum testosterone levels, the latter implying a positive effect of testosterone on spatial memory. APOE-ε4 was associated with poorer odor threshold test scores. These data suggest that HRT positively influences a limited number of olfactory and cognitive measures in the menopause.

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“…Twenty words formed the basis of this task, and were taken from the Schonell Graded Word Reading Test (SGWRT) [44], which consists of words that can be successfully read by 7-8 year old children of average reading ability. The word stimuli once again underwent degradation such that several different degraded versions were constructed.…”

Section: Word Stimulimentioning

confidence: 99%

Loss of high-level perceptual knowledge of object structure in DAT

Done

Hajilou

2005

Neuropsychologia

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Visual object recognition and naming deficits in patients with dementia of the Alzheimer type (DAT) have typically been attributed to deficits in semantic processing. On a visual object naming test, a group of mild DAT patients were found to suffer from anomia, compared to an age-matched control group. DAT naming errors were typically within category (commission), associative or circumlocutory errors. Performance on tests of low level visuo-spatial ability fell within the normal range. Together these results suggested that anomia resulted from a dysfunctional semantic system with intact visual perception. However, in a naming task using visually degraded images of familiar objects, the recognition threshold in DAT patients was significantly higher, indicating the need for a more visually complete object representation, before it could be accurately recognised. In a matched task using words visually degraded in an identical manner, the recognition threshold for DAT patients was very similar to that of the control group. It is argued that these results support the idea that impaired structural descriptions of objects (i.e., pre-semantic representation of an object within the visual perceptual system) combines with degraded semantic representations to produce anomia in DAT.

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Assessing memory deterioration with the wechsler memory scale, the national adult Reading Test, and the Schonell Graded Word Reading Test

Cited by 30 publications

References 16 publications

Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses

Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses

Influences of hormone replacement therapy on olfactory and cognitive function in postmenopausal women

Loss of high-level perceptual knowledge of object structure in DAT

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