Assessing risks of infection with herpes viruses during transfusion of donor blood and its components

Solomay, T. V.; Semenenko, T.A.; Karazhas, N.V.; Rybalkina, T.N.; Kornienko, M.N.; Bosh'yan, R.E.; Golosova, S.A.; Ivanova, I.V.

doi:10.21668/health.risk/2020.2.15

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…Такой подход позволяет обеспечить как высокое качество сохраняемых образцов, так и требования биологической безопасности. Последнее является чрезвычайно важной задачей, поскольку любой биологический материал может быть потенциально инфицирован патогенами, вызывающими болезни человека [14]. Перед поступлением в биобанк все образцы проходят строгий отбор, однако по ряду причин они не могут быть исследованы на наличие всех патогенных микроорганизмов.…”

Section: ключевые моменты что известно о предмете исследования?unclassified

Possibilities of a biobank for serological monitoring of infectious morbidity

Svitich,

Zverev,

Solomay

et al. 2023

Cardiovasc Ther Prev

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Currently, monitoring infectious morbidity, control and forecasting the epidemic process is a topical health problem.Aim. To analyze the capabilities of the biobank for serological monitoring of infectious diseases using the Epstein- Barr virus (EBV), which is associated with infectious mononucleosis, as well as somatic pathology, including cancer.Material and methods. Using the quantitative enzyme- linked immunosorbent assay for specific antibodies to various EBV proteins, we studied blood serum samples from healthy individuals (2010, 2016, 2019, 2020, 2021 and 2022) from the collection of the N. F. Gamaleya National Center of Epidemiology and Microbiology.Results. For the first time, the intensity of EBV epidemic process among apparently healthy adult residents of the capital was assessed using samples of biological material and a biobank information database. At the time of examination, 0,8% of individuals were not infected with EBV, and 9,4% suffered reactivation of a chronic infection. There were no significant changes in detection rate of markers over the years.Conclusion. Certified collections of blood sera can be effectively used to study population immunity, the prevalence of individual infections, population protection nationwide, etc.

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Section: ключевые моменты что известно о предмете исследования?unclassified

Possibilities of a biobank for serological monitoring of infectious morbidity

Svitich,

Zverev,

Solomay

et al. 2023

Cardiovasc Ther Prev

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Hand hygiene in medical organizations: implementation of the concept as an effective measure for HAI prevention

Smetanin¹

2022

Sanitary Doctor

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The article presents the results of a study aimed at substantiating hand hygiene in medical organizations as the most effective measure for preventing HCAI in the framework of the implementation of the National Concept for the Prevention of Infections Associated with Medical Care (approved by the Chief State Sanitary Doctor of the Russian Federation on November 6, 2011). It was found that healthcare-associated infections (HCAIs) are an urgent problem of modern Russian healthcare. The main causes of HCAI are insufficiently effective infection control methods in medical organizations and the overuse of antimicrobials. In the course of the study, such methods as content analysis, literature review, ranking, hypothetical-deductive method, generalization, formalization were used. The materials used were articles published in international bibliographic and abstract databases (Scopus, PubMed); official documents of the Russian Federation, as well as international documents (legislative acts, programs, conventions, etc.) on infections related to the provision of medical care. The performed systematic literature analysis suggests that one of the main measures to prevent HCAI is hand hygiene. It was found that the maximum result in the prevention of HCAI can be achieved through the implementation of a multimodal approach. Based on available scientific research, 5 key points have been identified when hand hygiene is mandatory for healthcare professionals. It was concluded that HCAI prevention should be multimodal, with successful implementation of HCAI prevention requiring cultural shifts at the hospital level, and coordination at the national level is needed to address the serious threat posed by HCAI.

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Epidemiological characteristics of Epstein–Barr virus infection

Solomay¹,

Semenenko²,

Tutelyan³

et al. 2022

Journal of microbiology, epidemiology and immunobiology

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Introduction. The Epstein–Barr virus (EBV) is one of the most common pathogens — it infects 90% of the world’s population. However, specific characteristics of the EBV infection epidemic process remain unidentified. The previous studies focusing on assessment of incidence rates for infectious mononucleosis (IM) tend to ignore the serological status of the population.The aim of the study was to identify epidemiological characteristics and assess the prevalence of serological markers for EBV infection for further epidemic control measures development.Materials and methods. In Moscow, the thorough analysis was performed using the data on IM incidence (Form 2 "Data on Infectious and Parasitic Diseases") and test results for 138,232 people checked for presence of VCA IgG, EBNA IgG, VCA IgM, EA IgG, and EBV DNA in their blood and saliva in 2011–2020.Results. The periodic pattern of IM incidence was discovered, demonstrating the repetitive peaks every 9 to 11 years and a strong direct correlative relationship with detection rates for active EBV infection markers. The intra-annual dynamics of IM incidence is characterized by a seasonal upswing during cold seasons of the year, reaching its peaks in October, November, or February and associated with a marked decrease in the VCA IgG and EBNA IgG seroprevalence. Children within the 1 to 17-year age range are groups at risk for acquiring primary infection, demonstrating significantly lower detection rates for chronic EBV infection (VCA IgG and EBNA IgG) markers and higher rates for VCA IgM and EBV DNA markers in blood compared to adults. The contribution of adult population to the epidemic process is formed through reactivation of chronic infection, which is observed primarily among women.Conclusion. The identified characteristics are essential for comprehensive understanding of the EBV infection epidemic process and can be used for developing preventive and anti-epidemic measures.

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Assessing risks of infection with herpes viruses during transfusion of donor blood and its components

Cited by 4 publications

References 4 publications

Possibilities of a biobank for serological monitoring of infectious morbidity

Possibilities of a biobank for serological monitoring of infectious morbidity

Hand hygiene in medical organizations: implementation of the concept as an effective measure for HAI prevention

Epidemiological characteristics of Epstein–Barr virus infection

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