Assessing the Accuracy and Reproducibility of Computer‐Assisted Analysis of ¹²³I‐FP‐CIT SPECT Using BasGan (V2)

Abstract

BasGan-assisted evaluations of (123) I-FP-CIT-SPECT were very useful, particularly in "doubtful" cases. Multicenter studies are mandatory before routine use of BasGan.

Multicenter Semiquantitative Evaluation of 123I‐FP‐CIT Brain SPECT

“…While in a single‐center setting, the use of BasGan allowed operators to achieve good reproducibility and accuracy, this study shows that in a multicenter setting, the level of accuracy is high, once the procedure has been appropriately standardized.…”

“…Another paper shows discrepancies in decisions taken by nuclear physicians on 123 I‐FP‐CIT reporting, albeit limited to few cases . Finally, a quantitative approach can also assist junior nuclear medicine physicians when interpreting scans, until more experience is acquired …”

“…The majority of scans can be easily reported after a simple qualitative evaluation by an expert reader . However, in “borderline” scans, characterized by a high interobserver discrepancy, or when an assessment of disease progression is required, a quantification of imaging data is often useful . A quantitative analysis can also provide a reference value to express the wide clinical variability, which is more suitable for a correlative analysis with other disease markers, such as those expressing severity of motor impairment, or monitoring of neuroprotective treatments .…”

“…BasGan V2 is a PC‐based software, freely available from the Italian association of Nuclear Medicine website (http://www.aimn.it/?page_id=340). It has been already used in a multicenter study of healthy volunteers and in some unicentric studies of suspected Parkinsonian patients or with de novo Parkinson's disease (PD) . However, to the best of our knowledge, no multicenter studies so far have assessed the accuracy of semiquantitative, BasGan‐assisted evaluations of DAT SPECT, to predict neurodegenerative Parkinsonian syndrome (NPS).…”

Optimization of Parameters for Quantitative Analysis of 123I-Ioflupane SPECT Images for Monitoring Progression of Parkinson Disease

“…Therefore, visual reads had a very high negative predictive value but had more room for improvement in positive predictive value. To aid the clinician with assessing the quantitative loss of dopaminergic transporter sites in patients, several image processing software packages have been developed over the years (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Computer-aided analysis can provide critical adjunct information or a ''second read,'' which may be particularly useful for challenging cases (15)(16)(17).…”