Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study

Cunico, Cássia; Picheth, Geraldo; Correr, Cassyano Januário; Scartezini, Mariléia

doi:10.4321/s1886-36552014000200002

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…Parallel to findings from a previous study, adherence to medication was reported to reduce significantly over time. 29 In the study by Cunico et al good adherence to antihyperlipidemia was observed in 90% of patients in the first 8 months of treatment, but it reduced to approximately 80% after 20 months. 29 These results show that over time, it is imperative that the importance of medication adherence be emphasized for patients with long-term medication use.…”

Section: Discussionmentioning

confidence: 95%

“… 29 In the study by Cunico et al good adherence to antihyperlipidemia was observed in 90% of patients in the first 8 months of treatment, but it reduced to approximately 80% after 20 months. 29 These results show that over time, it is imperative that the importance of medication adherence be emphasized for patients with long-term medication use. The current study also found that patients with human immunodeficiency virus were nine times more likely to be adherent to medication than patients with chronic kidney disease (OR 9.08, 95% CI 3.25–25.3, P <0.05).…”

Section: Discussionmentioning

confidence: 95%

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The influence of cultural and religious orientations on social support and its potential impact on medication adherence

Hatah¹,

Lim²,

Ali³

et al. 2015

PPA

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PurposeSocial support can positively influence patients’ health outcomes through a number of mechanisms, such as increases in patients’ adherence to medication. Although there have been studies on the influence of social support on medication adherence, these studies were conducted in Western settings, not in Asian settings where cultural and religious orientations may be different. The objective of this study was to assess the effects of cultural orientation and religiosity on social support and its relation to patients’ medication adherence.MethodsThis was a cross-sectional study of patients with chronic diseases in two tertiary hospitals in Selangor, Malaysia. Patients who agreed to participate in the study were asked to answer questions in the following areas: 1) perceived group and higher authority cultural orientations; 2) religiosity: organizational and non-organizational religious activities, and intrinsic religiosity; 3) perceived social support; and 4) self-reported medication adherence. Patients’ medication adherence was modeled using multiple logistic regressions, and only variables with a P-value of <0.25 were included in the analysis.ResultsA total of 300 patients completed the questionnaire, with the exception of 40 participants who did not complete the cultural orientation question. The mean age of the patients was 57.6±13.5. Group cultural orientation, organizational religious activity, non-organizational religious activity, and intrinsic religiosity demonstrated significant associations with patients’ perceived social support (r=0.181, P=0.003; r=0.230, P<0.001; r=0.135, P=0.019; and r=0.156, P=0.007, respectively). In the medication adherence model, only age, duration of treatment, organizational religious activity, and disease type (human immunodeficiency virus) were found to significantly influence patients’ adherence to medications (adjusted odds ratio [OR] 1.05, P=0.002; OR 0.99, P=0.025; OR 1.19, P=0.038; and OR 9.08, P<0.05, respectively).ConclusionWhen examining religious practice and cultural orientation, social support was not found to have significant influence on patients’ medication adherence. Only age, duration of treatment, organizational religious activity, and disease type (human immunodeficiency virus) had significant influence on patients’ adherence.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

The influence of cultural and religious orientations on social support and its potential impact on medication adherence

Hatah¹,

Lim²,

Ali³

et al. 2015

PPA

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“…It reduces the patients’ quality of life, wastes health care resources, and increases health care costs. [ 8 9 10 ]…”

Section: Introductionmentioning

confidence: 99%

Adherence to prescribed medications of Iranian traditional medicine in a group of patients with chronic disease

et al. 2016

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Objective:The extent to which a person's health-related behavior corresponds with medical instructions (adherence) is an important modifier of health system effectiveness. This study was designed to determine the patients’ adherence to Iranian traditional medicine in a group of patients with chronic disease.Methods:Convenience sampling was used to enroll 320 patients with chronic diseases from January 2014 to January 2015 in clinics of traditional medicine affiliated with medical universities in Tehran. Morisky Medication Adherence Scale (MMAS) was used to measure the adherence. After describing the variables and the frequency of adherence, logistic regression analysis was used to determine the influencing factors.Findings:Mean age was 40.8 (standard deviation [SD] =13) years. The mean of the duration of disease was 54.6 (SD = 56.1) months and mean of the duration of referring to the clinics 6.5 (SD = 6.9) months. Total score of MMAS was zero in 33 (10.3%) of patients (high adherence), one or two in 128 (40%) of patients (moderate adherence), and more than two in 159 (49.7%) of patients (low adherence). Forgetfulness, bad taste, not availability, and the high cost of the drugs were the most commonly reported causes of non-adherence. Adherence was associated with age (odds ratio [OR] =1.05, 95% confidence interval [95% CI] 1–1.1), marriage (OR = 10.8, 95% CI 2.05–57.6), number of prescribed drugs (OR = 0.05, 95% CI 0.02–0.14), and duration of disease (OR = 1.01, 95% CI 1–1.02).Conclusion:Considering the low adherence in users of medications of Iranian traditional medicine, health care practitioners need to be trained in adherence and the influencing factors and also to use some interventions to increase the adherence.

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“…In addition, atorvastatin has been identified as the most cost-effective option for patients with dyslipidemia in the Colombian health context when moderate to high intensity treatments are required 14 . When comparing these results with studies from other countries, atorvastatin has also been the most prescribed in Taiwan, but only at 37% 15 , whereas research in Italy and Brazil found a predominance of simvastatin 16 , 17 .…”

Section: Discussionmentioning

confidence: 68%

Lipid-lowering drug prescriptions in a group of Colombian patients

2019

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Introduction. Lipid-lowering drugs, especially statins, have shown great relevance in preventing and treating cardiovascular diseases.Objective. To determine the prescription patterns of lipid-lowering drugs and the variables associated with their use in a Colombian population.Materials and methods. This is a cross-sectional descriptive study. From a drug dispensing database of approximately 4.5 million Colombian health system affiliates, patients of all ages and both sexes treated with lipid-lowering agents (statins, fibrates, ezetimibe) were identified between January and March, 2017. Demographic, pharmacological and co-medication variables were included.Results. In total, 103,624 patients were identified as being treated with lipid-lowering agents. The average age was 67.5 years, and 49.8% were 65 years or older. Women comprised 58.0% of the patients. Statins were the most used (n=96,910; 93.5%), and atorvastatin (n=80,812; 78.0%) and lovastatin (n=12,621; 12.2%) were the most frequent. The mean atorvastatin dose was 30.3 mg/day, and 49.9% of its users received presentations of 40 mg or more. A total of 9,258 (8.9%) patients received fibrates, and only 780 (0.8%) were taking ezetimibe. Of this population, 94.9% were treated with lipid-lowering monotherapy, and 97.3% (n=100,813) had co-medication for their comorbidities, with the most frequent being antihypertensive (89.1%), antiplatelet (57.8%), antidiabetic (31.5%) and antiulcerative agents (34.2%).Conclusions. Atorvastatin is currently the most frequently used lipid-lowering drug in this group of Colombian patients, especially in monotherapy and at doses close to the defined daily dose. Only half received high-intensity doses. New studies are required to verify the efficacy of these therapies.

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Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study

Cited by 6 publications

References 40 publications

The influence of cultural and religious orientations on social support and its potential impact on medication adherence

The influence of cultural and religious orientations on social support and its potential impact on medication adherence

Adherence to prescribed medications of Iranian traditional medicine in a group of patients with chronic disease

Lipid-lowering drug prescriptions in a group of Colombian patients

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