Assessing the association between the circulating levels of inflammatory cytokines and the risk of tuberculosis: A bidirectional two-sample mendelian randomization study

Zhang, Shun-Xian; Lu, Zhen-Hui; Wang, Mei-Ti; Shen, Yu-Ping; Duan, Lei; Guan, Shi-Yang; Chen, Mu-Xin; Lu, Yan; Yang, Ming; Wang, Lei; Yang, Guo-Bing; Lv, Wen-Wen; Wang, Ji-Chun; Zheng, Jin-Xin

doi:10.1016/j.meegid.2023.105524

Cited by 3 publications

(1 citation statement)

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“…There have been previous studies exploring the role of various cytokines in TB pathogenesis and diagnosis. 24 , 25 Importantly, this study further delved into the comparative cytokine profiles between SNPT and SPPT patients. Interferon-α, a member of the type I interferon family, has been demonstrated to be pivotal in the host immune defense against Mtb infection.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of the clinical utility of multi-cytokine profiles in smear-negative pulmonary tuberculosis

Li,

Zhao,

Han

et al. 2024

SMJ

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Objectives: To evaluate cytokine profiles and interferon-gamma release assay (IGRA) for their diagnostic capabilities in the differentiation of tuberculosis (TB) from non-TB conditions, as well as smear-negative pulmonary tuberculosis (SNPT) from smear-positive pulmonary tuberculosis (SPPT). Methods: A total of 125 participants were included, 77 of whom had TB and 48 who didn’t, and demographic, clinical, and laboratory data were collected, including cytokine levels and IGRA results. The TB patients were further divided into 2 subgroups: SNPT (n=42) and SPPT (n=35). Results: Compared to non-TB, the TB group had lower BMI, higher WBC, neutrophils, monocytes, ESR and CRP ( p <0.05). TB patients showed higher IL-2, IL-6, IFN-γ, IL-8 ( p <0.001) and higher IGRA positivity (88.3% versus [vs.] 29.2%, p <0.001). Between SNPT and SPPT, moderate effect sizes were observed for IFN-α, IL-2, IL-10, IL-8 (Cohen’s d 0.59-0.76), with lower IGRA positivity in SNPT (81.0% vs. 97.1%, p =0.015). ROC analysis indicated IFN-α, IL-2, IL-10, IL-8 had moderate accuracy for SNPT diagnosis (AUCs 0.668-0.734), and combining these improved accuracy (AUC 0.759, 80% sensitivity, 64.2% specificity). Conclusion: A multi-biomarker approach combining these cytokines demonstrates enhanced diagnostic accuracy for tuberculosis.

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Section: Discussionmentioning

confidence: 99%