Assessing the association between vitamin D receptor and dental age variability

Abstract

Objectives To explore the association between genetic polymorphisms in vitamin D receptor (VDR), vitamin D serum levels, and variability in dental age. Material and methods This cross-sectional study was based on an oral examination, panoramic radiograph analysis, and genotype analysis from biological samples. Dental age was evaluated using two different methods: Demirjian et al. (Hum Biol 45:211–227, 1973) and Hofmann et al. (J Orofac Orthop.78:97–111, 2017). The genetic polymorphisms BglI (rs739837) and FokI (rs2228570) in VDR were genotyped through real-time PCR. The vitamin D level was also measured in the serum. Delta (dental age–chronological age) was compared among genotypes in VDR in the co-dominant model. Multiple linear regression analysis was also performed. An established alpha of 5% was used. Results Genotype distributions of BglI and FokI were not associated with dental maturity (p > 0.05). In the logistic regression analyses, genotypes in BglI and FokI and vitamin D levels were not associated with variability in dental age (p > 0.05). Conclusions The genetic polymorphisms BglI and FokI in VDR and the vitamin D levels were not associated with variability in dental age. Clinical relevance To unravel the factors involved in dental maturity can improve dental treatment planning in pediatric and orthodontic practice.

The investigation of WNT6 and WNT10A single nucleotide polymorphisms as potential biomarkers for dental pulp calcification in orthodontic patients

“…SNPs are the most common type of genetic variation in humans. It is a type of genetic variant that involves a variation of a single base pair in the genome [32] and is associated with a variety of conditions, including endodontic [33][34][35] and orthodontic phenotypes [21,22,24,27,33]. It has been stated that these variants could determinate differences in individual predisposition, and even particularly different phenotypes on a similar population [36].…”

Estrogen deficiency influences SEC23A gene expression in the odontogenic region of incisors – a murine model study

“…80% to 90% of serum levels of vitamin D are synthesized endogenously under UVB irradiation, the remainder, 10% to 20%, come from the diet, the main dietary sources being cholecalciferol (D 3 ) and ergosterol (D 2 ). Estrogen deficiency and vitamin D deficiency share several adverse health outcomes, including bone resorption itself, mood disorders, increased risk of cardiovascular disease and cancers [24][25][26][27][28] affect growth and development [2][3][4][29][30][31].…”

Investigating the association between dental age and polymorphisms in genes encoding estrogen receptors

“…The identification of specific genetic markers associated with tooth development will enable personalized treatment plans to maximize the efficiency and predictability of dental and orthodontic interventions for each patient. Genetic polymorphisms have also been associated with an increased risk of developing tooth disorders, such as delayed tooth eruption, 27 primary failure of eruption, 28 among others. Therefore, in this study, we investigated whether genetic polymorphisms in ESR1 and ESR2 are associated with delayed or advanced dental age in a sample of Brazilian children.…”