Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis

Kapodistrias, Nikolaos; Mavridis, Konstantinos; Batistatou, Anna; Gogou, Pinelopi; Karavasilis, Vasilios; Sainis, Ioannis; Briasoulis, Evangelos; Scorilas, Andreas

doi:10.18632/oncotarget.14320

Cited by 20 publications

(16 citation statements)

References 63 publications

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“… 12 , 13 MicroRNAs are increasingly emerging as important regulators of tumorigenesis. miR-155 acts as an oncomir in various human cancers, including liposarcoma, 14 lung cancer, 15 cervical cancer, 16 acute myeloid leukemia, 17 hepatocellular carcinoma, 18 breast cancer, 19 and oral squamous carcinoma. 20 However, its expression and potential molecular mechanism in uveal melanoma are not yet clear.…”

Section: Introductionmentioning

confidence: 99%

MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression

Peng¹,

Liu²,

Liu³

2017

Technol Cancer Res Treat

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MicroRNAs refer to small RNA molecules that destroy the messenger RNA by binding on them inhibiting the production of protein. However, the role of miR-155 in uveal melanoma metastasis remains largely unknown. In this study, we found that miR-155 was upregulated in both uveal melanoma cells and tissues. Transfection of miR-155 mimic into uveal melanoma cells led to an increase in cell growth and invasion; in contrast, inhibition of miR-155 resulted in opposite effects. Also, we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells. In conclusion, miR-155 acts as a tumor promotor in uveal melanoma through increasing cell proliferation and invasion. Thus, miR-155 might serve as a potential therapeutic target in patients with uveal melanoma.

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Section: Introductionmentioning

confidence: 99%

MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression

Peng¹,

Liu²,

Liu³

2017

Technol Cancer Res Treat

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“…A review of survival data from the literature indicates that several clinico-morphological factors such as tumour size, histologic subtype [2], and grading [2,3] or even selected molecular changes [4,5,6,7] may significantly affect disease-free or/and overall survival of LPS patients.…”

Section: Introductionmentioning

confidence: 99%

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

Harazin-Lechowska¹,

Ambroziak-Lackowska²,

Ryś³

et al. 2017

pjp

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The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours. Based on evaluation of material from 54 liposarcomas which was available for both histological and FCM analysis, we distinguished four prognostic groups of patients. The best prognosis was noticed for diploid and grade G1 well-differentiated or myxoid liposarcomas localised on extremities. None of the patients with lipoma-like WDLPS and myxoid liposarcoma grade 1 metastasised, while metastases were observed among patients with dedifferentiated LPS (70% of 5-year MFS) and cellular myxoid or round cell liposarcoma (20% of 5-year MFS, only). The metastasis-free survival curves for the above mentioned groups of patients differed significantly (p = 0.00001)

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“…Long survival is correlated with the active resection of recurrence and recognition of high-grade dedifferentiated type liposarcoma at an early stage[ 10 , 11 ]. In addition, according to recent basic research, although limited compared to other malignancies, formalin-fixed paraffin-embedded tissue biomarkers, namely microRNA-155, may be novel independent indicators of unfavorable prognosis in liposarcoma[ 14 ]. However, there remains a need to identify predictive biomarkers for the better selection of target population and testing of combinations of drugs with the ultimate goal of improving outcomes[ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature

Usuda

Takeshima

Sangen

et al. 2018

WJCC

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A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Dynamic computed tomography revealed a highly enhanced effect from the portal-venous phase continuing to the equilibrium phase. T1-weighted gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced image revealed a high intensity effect at the early phase that continued to the next phase. On the other hand, it contained a low intensity area by a fat suppression of that image. In addition, a T2-weighted image did not show a high intensity effect. Laparotomy was performed on the second day of hospitalization. The tumor had arisen from the ligamentum teres of the liver, and no metastasis or invasion of other organs was noted. It consisted of a lipid component of mature adipocytes and a fibrous component of deep dyeing pleomorphic or multinuclear atypical stromal cells. Immunohistochemical study of the atypical stromal cells demonstrated that they were positive for MDM2 and CDK4. A pathological diagnosis of atypical lipomatous tumor (ALT) was made, and the patient was discharged on the eighth day following the procedure. At the 6-mo follow-up dynamic CT, the patient was free of recurrence or metastasis. We experienced a patient with ALT in the ligamentum teres of the liver. This case suggests the need for a careful and detailed examination when encountering patients presenting with a mass; when neoplastic lesion is confirmed by image inspection, we should thoroughly investigate, including further image investigations and pathologic examination. The latter is the most important.

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Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis

Cited by 20 publications

References 63 publications

MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression

MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature

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