This study explores the dynamics of organizational politics, employee resilience, person-job fit, and turnover intentions among health workers in Ghanaian public and private hospitals, all under the framework of the person-environment fit theory. The convenience sampling technique was used to collect data from 371 participants across six distinct regions of Ghana. The collected data were analyzed using partial least squares structural equation modeling. This study indicates that organizational politics have a significant positive impact on turnover intentions and employee resilience, and higher resilience is linked to a lower inclination to leave. This study found that employee resilience partially mediates the relationship between organizational politics and turnover intentions. Furthermore, it was discovered that person-job fit moderates the relationship between organizational politics and both inclination to leave and resilience. These findings highlight the importance for health service administrators to foster staff resilience and person-job fit while addressing organizational politics through open communication and equitable decision-making.