Assessing the maxillary sinus mucosa of rabbits in the presence of biodegradable implants

Perez, André Coura; Silva-Cunha, Armando; Fialho, Sílvia Ligório; Silva, Lívia Mara; Dorgam, João Vicente; Murashima, Adriana de Andrade Batista; Ribeiro‐Silva, Alfredo; Rossato, Maria; Anselmo‐Lima, Wilma Terezinha

doi:10.5935/1808-8694.20120031

Cited by 8 publications

(11 citation statements)

References 18 publications

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“…Animal studies make it possible to monitor inflammatory changes in the nasal and sinus mucosa over a period of time [59,60]. Rabbits are the most suitable animal model for evaluating nasal drug-eluting implants [59,60,61]. This is because the sinuses of rabbits and humans show similarities with respect to their anatomies [62].…”

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

“…The in vivo characterization of nasal implants includes histological and nasal lavage analyses, as well as peripheral blood levels screening [59]. During in vivo characterization, standard surgical procedures are performed and the implant is placed in the maxillary sinus [59,60]. As the sinuses are paired cavities, one of the sinuses receives the drug-loaded implant, whereas no implant is placed in the other sinus.…”

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

“…As the sinuses are paired cavities, one of the sinuses receives the drug-loaded implant, whereas no implant is placed in the other sinus. A control group of animals receive non-drug eluting implant [60]. After surgical implantation, the animals are sacrificed at selected post-operative days for histological analysis following standard hematoxylin and eosin staining.…”

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

“…Histological analysis of the sinus mucosa is used to determine mucosal, luminal and inflammatory changes due to the implants [59,61], as well as the extent of implant degradation [59]. In standard experiments, inflammatory changes in the group receiving drug-eluting implants are compared to the group receiving non-drug eluting implant [60]. In standard animal studies, drug levels are also analyzed in the nasal lavage and blood [59,60].…”

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

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Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Parikh¹,

Anand²,

Ugwu³

et al. 2014

Pharmaceutics

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Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested as reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates for nasal implants, formulation methods/optimization and characterization methods. Clinical applications and important considerations were also addressed. Clinically-approved implants (Propel™ implant, the Relieva stratus™ MicroFlow spacer, and the Sinu-Foam™ spacer) for CRS treatment was an important focus. The advantages and limitations, as well as future considerations, challenges and the need for additional research in the field of nasal drug implant development, were discussed.

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Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

Section: Characterization Of Drug-eluting Nasal Implantsmentioning

confidence: 99%

See 2 more Smart Citations

Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Parikh¹,

Anand²,

Ugwu³

et al. 2014

Pharmaceutics

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“…The most frequently used biodegradable polymers are polyesters such as caprolactone, polylactic acid (PLA) and various lactic and glycolic acid copolymer types (PLGA), the latter two being extensively used 7 . PLGA can be easily produced and has predictable decomposition kinetics.…”

Section: Introductionmentioning

confidence: 99%

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

et al. 2014

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PURPOSE:To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. METHODS:A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively). RESULTS:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2. CONCLUSION:The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.

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Sustained co-release of ciprofloxacin and dexamethasone in rabbit maxillary sinus using polyvinyl alcohol-based hydrogel microparticle

Jalessi,

Moghaddam,

Khanmohammadi

et al. 2024

J Mater Sci: Mater Med

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Topical delivery to paranasal sinuses through sustained-release stents is one of the new horizons in treating chronic rhinosinusitis (CRS). This study aims to introduce and evaluate sustained co-release of encapsulated ciprofloxacin (CIP) and dexamethasone (DEX) in polyvinyl alcohol-based carriers within the maxillary sinus of rabbit animals. DEX and CIP were loaded in a tyramine-substituted polyvinyl alcohol microparticle (PVATyr MP). The mechanical stability, degradability, and sustained-release patterns of both drugs as well as cellular cytocompatibility were assessed in vitro. The PVATyr MPs were then injected into the maxillary sinus of rabbits and they were monitored weekly for 21 days. Nasal endoscopy, MRI imaging, and tissue microscopy were used to follow the changes and compared them with the control condition. Also, the concentrations of drugs were evaluated in the maxillary sinus and blood samples over the study period. Produced PVA-based MPs possessed a relatively narrow particle size distribution (CV 7.7%) with proper physical stability until 30 days of incubation. The uniform-sized PVATyr MPs and their surrounding hydrogel showed sustained-release profiles for DEX and CIP for up to 32 days in vitro. The injected drugs-loaded hydrogel showed complete clearance from the maxillary sinus of rabbits within 28 days. The concentrations of DEX and CIP in mucosal remained within the therapeutic window when measured on days 7, 14, and 21, which were well above the plasma concentrations without any pathological changes in endoscopy, MRI imaging, and histological examinations. DEX/CIP loaded PVATyr MPs provided an effective, controlled, and safe sustained-drug delivery in both in vitro and in vivo analyses at therapeutic concentrations with minimal systemic absorption, suggesting a promising treatment approach for CRS. Graphical Abstract

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Assessing the maxillary sinus mucosa of rabbits in the presence of biodegradable implants

Abstract: Signs of toxicity or mucosal inflammation were not observed in the maxillary sinuses of rabbits given prednisolone-eluting implants or non-drug-eluting implants.

Cited by 8 publications

References 18 publications

Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Sustained co-release of ciprofloxacin and dexamethasone in rabbit maxillary sinus using polyvinyl alcohol-based hydrogel microparticle

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