Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism

Xia, Ziqiang; Mei, Hu; Zheng, Lirong; Zheng, Endian; Deng, Min; Wu, Jin‐Ming; Xiong, Shengwu

doi:10.5937/jomb0-37597

“…При стеатогепатите -противоположная картина: усиление процессов липопероксидации с увеличением содержания каталазы, которая указывает на гибель клеток. Это также согласуется с работами Perlemuter и Xia с коллегами [29,30].…”

Section: заболевания билиарной системы и печениunclassified

Traits of the lipid peroxidation – antioxidant defence system in non-alcoholic fatty liver disease

Smirnova,

Lagutinskaya,

Kasparova

2024

Medicinskij sovet

0

View full text Add to dashboard Cite

Introduction. Non-alcoholic fatty liver disease (NAFLD) is caused by excess accumulation of fats in hepatocytes. An increasing percentage of adipose tissue is associated with chronic inflammation and developing oxidative stress. These pathological conditions can lead to the progression of steatosis to steatohepatitis with the further development of fibrosis and cirrhosis.Aim. To evaluate the indicators of lipid peroxidation and antioxidant defence factors in steatosis and steatohepatitis in patients with NAFLD.Materials and methods. During the work, 116 patients with NAFLD were examined, of which 65 had steatosis, and 51 had steatohepatitis. The study of biochemical markers of metabolism of proteins, fats and carbohydrates was performed on a Mindray BS-380 biochemical analyzer. The indicators of the LPO-AOD system (MDA, SOD, catalase, ceruloplasmin) were assessed using spectrophotometric methods. Statistical data processing was carried out in the STATISTICA and SPSS 26 programs using nonparametric tests.Results. Patients with steatohepatitis had more severe dyslipidemia, blood triglyceride, total cholesterol levels and LDL were significantly higher (p > 0.05). Impaired cholesterol metabolism was reflected by a high atherogenic index of 3.46. In patients with steatosis, changes in the lipid profile were less pronounced. No disturbances in protein and carbohydrate metabolism were detected. Increased levels of liver markers were noted only in patients with steatohepatitis. The change in the balance in the LPO- AOD system was more pronounced in patients with steatohepatitis; they had a high level of MDA, a high concentration of catalase; in patients with steatosis, only a decrease in the level of MDA and an increase in the level of ceruloplasmin were noted.Conclusion. Dyslipidemia, hepatocyte cytolysis and liver fibrosis are detected in patients with steatohepatitis. Disturbances in the LPO-AOD system have been identified in both forms of NAFLD, but in steatosis they are compensated. In steatohepatitis, disturbances in “LPO-AOD” in the form of an increase in pro-oxidants and a decrease in antioxidants cause the development of oxidative stress.

show abstract

“…Ceruloplasmin (CP) is responsible for 90% of copper transport. CP is an acute response protein with anti-inflammatory properties, and its levels rise in the presence of inflammatory diseases (Xia et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

2023

ZJPAS

0

View full text Add to dashboard Cite

The long periods of working hours at the hospital, and exposure to residues of harmful substances such as anticancer drugs and others lead to excessive formation of free radicals in the body. The aim of this study was to evaluate peroxynitrite, folic acid, homocysteine, ceruloplasmin, and copper in hospital cleaning worker staff (janitors) exposed to residue of different types of substances such as patients' blood, urine, and tools, as well as anticancer drugs in the work setting. This study was conducted among 40 subjects. Twenty subjects (from hospital cleaning staff) were considered hospital cleaning worker staff subjects, twenty other subjects were included as a healthy control group. The mean levels of peroxynitrite, folic acid, and ceruloplasmin in the hospital cleaning staff were (90.80± 23.93, 3.305±1.388, and 269.9±71.86) and in a healthy control group were (19.7±6.551, 6.232±1.738, and 129.88±37.98) µmol/L, respectively, which are statistically high significant. In contrast, the mean serum levels of homocysteine in two groups were (10.84±4.695 and 8.21±1.31) µmol/L, respectively, which are statistically significant. The average copper content was also found in both groups, although it was statistically insignificant and measured (129.34±.26.51) µg/dL in the hospital cleaning staff group and (133.91±11.25) µg/dL in the control group. These findings suggest that long-term exposure to residues of various types of substances in the work setting may cause an induced oxidative stress that results in a number of diseases including cancer.

show abstract

Biliary tract dysfunctions: Possibilities of combined drugs of plant origin as advantage therapy

Trukhan,

Rozhkova,

Samoilova

et al. 2024

Medicinskij sovet

0

View full text Add to dashboard Cite

Introduction. Non-alcoholic fatty liver disease (NAFLD) is caused by excess accumulation of fats in hepatocytes. An increasing percentage of adipose tissue is associated with chronic inflammation and developing oxidative stress. These pathological conditions can lead to the progression of steatosis to steatohepatitis with the further development of fibrosis and cirrhosis.Aim. To evaluate the indicators of lipid peroxidation and antioxidant defence factors in steatosis and steatohepatitis in patients with NAFLD.Materials and methods. During the work, 116 patients with NAFLD were examined, of which 65 had steatosis, and 51 had steatohepatitis. The study of biochemical markers of metabolism of proteins, fats and carbohydrates was performed on a Mindray BS-380 biochemical analyzer. The indicators of the LPO-AOD system (MDA, SOD, catalase, ceruloplasmin) were assessed using spectrophotometric methods. Statistical data processing was carried out in the STATISTICA and SPSS 26 programs using nonparametric tests.Results. Patients with steatohepatitis had more severe dyslipidemia, blood triglyceride, total cholesterol levels and LDL were significantly higher (p > 0.05). Impaired cholesterol metabolism was reflected by a high atherogenic index of 3.46. In patients with steatosis, changes in the lipid profile were less pronounced. No disturbances in protein and carbohydrate metabolism were detected. Increased levels of liver markers were noted only in patients with steatohepatitis. The change in the balance in the LPO- AOD system was more pronounced in patients with steatohepatitis; they had a high level of MDA, a high concentration of catalase; in patients with steatosis, only a decrease in the level of MDA and an increase in the level of ceruloplasmin were noted.Conclusion. Dyslipidemia, hepatocyte cytolysis and liver fibrosis are detected in patients with steatohepatitis. Disturbances in the LPO-AOD system have been identified in both forms of NAFLD, but in steatosis they are compensated. In steatohepatitis, disturbances in “LPO-AOD” in the form of an increase in pro-oxidants and a decrease in antioxidants cause the development of oxidative stress.

show abstract

Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism

Cited by 4 publications

References 30 publications

Traits of the lipid peroxidation – antioxidant defence system in non-alcoholic fatty liver disease

Traits of the lipid peroxidation – antioxidant defence system in non-alcoholic fatty liver disease

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

Biliary tract dysfunctions: Possibilities of combined drugs of plant origin as advantage therapy

Contact Info

Product

Resources

About