Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease

Senzaki, Hideaki; Chen, Chen Huan; Masutani, Satoshi; Taketazu, Mio; Kobayashi, Jun; Kobayashi, Toshiki; Sasaki, Nozomu; Asano, Haruhiko; Kyo, Shunei; Yokote, Yuji

doi:10.1067/mtc.2001.115424

Cited by 42 publications

(49 citation statements)

References 38 publications

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“…19 Ventricular diastolic stiffness was also computed from the data obtained during inferior vena cava occlusion by fitting the end diastolic P-A relationship to a monoexponential function [PϭPoϩ␣(e ␤EDAI Ϫ1)] yielding passive diastolic chamber stiffness (␤).…”

Section: Discussionmentioning

confidence: 99%

Ventricular–Vascular Stiffening in Patients With Repaired Coarctation of Aorta

Senzaki¹,

Iwamoto²,

Ishido³

et al. 2008

Circulation

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Background-Despite successful repair, patients with coarctation of the aorta (COA) often show persistent hypertension at rest and/or during exercise. Previous studies indicated that the hypertension is mainly due to abnormalities in the arterial bed and its regulatory systems. We hypothesized that ventricular systolic stiffness also contributes to the hypertensive state in these patients in addition to increased vascular stiffness. Methods and Results-The study involved 43 patients with successfully repaired COA and 45 age-matched control subjects. Ventricular systolic stiffness (end systolic elastance) and arterial stiffness (effective arterial elastance) were measured invasively by ventricular pressure-area relationship during varying preload before and after ␤-adrenergic stimulation. The mean systolic blood pressure was significantly higher with concomitant increases in both end systolic elastance and effective arterial elastance in patients with COA compared with control subjects (113.2Ϯ16.8 versus 91.0Ϯ9.1 mm Hg, 44.5Ϯ17.0 versus 19.2Ϯ6.7 mm Hg/mL/m 2 , and 27.8Ϯ11.4 versus 20.2Ϯ4.8 mm Hg/mL/m 2 , respectively; PϽ0.01 for each). End systolic elastance and effective arterial elastance of patients with COA showed exaggerated responses to ␤-adrenergic stimulation, further amplifying blood pressure elevation. Quantification analyses assuming that ventricular systolic stiffness of patients with COA is equal to that of the control revealed that ventricular systolic stiffness accounts for approximately 50% to 70% of the elevated blood pressure in patients with COA. Furthermore, combined ventricular-arterial stiffening amplified systolic pressure sensitivity to increased preload during abdominal compression and limited stroke volume gain/relaxation improvement induced by ␤-adrenergic stimulation. Conclusions-Increased ventricular systolic stiffness, coupled with increased arterial stiffness, plays important roles in hypertension in patients with repaired COA. Thus, ventricular systolic stiffness is a potentially suitable target for reduction of blood pressure and improvement of prognosis of patients with COA. (Circulation. 2008;118[suppl 1]:S191-S198.)

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Section: Discussionmentioning

confidence: 99%

Ventricular–Vascular Stiffening in Patients With Repaired Coarctation of Aorta

Senzaki¹,

Iwamoto²,

Ishido³

et al. 2008

Circulation

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“…Pressure-volume (PV) loops provide a mechanism to directly access stroke work per cardiac cycle and hence myocardial O 2 consumption (Sagawa et al, 1988). More recently, pressure-area (PA) loops have been used to define cardiac dynamics in mammalian (Senzaki et al, 2001) and avian systems (Tobita and Keller, 2000). Both PV and PA loops have been used extensively to study the energetics of cardiac contraction and dynamics of cardiac function in the ventricles of mammalian and avian systems, yet this tool has found limited use in the study of cardiac dynamics in the single ventricle of animals possessing an open circulatory system (Wilkens, 1999).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the pressure–volume relationship of the single ventricle of the grass shrimp, Palaemonetes pugio

Guadagnoli

Tobita

Reiber

2007

Journal of Experimental Biology

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PV loops generated in this study, the ventricle of Palaemonetes pugio processes the same primary phases of the cardiac cycle as ventricles from the multi-chambered hearts of vertebrates: (1) isovolumic contraction, (2) ventricular emptying, (3) isovolumic relaxation and (4) ventricular filling. The area enclosed by the PV loop provides a measure of stroke work and when multiplied by heart rate provides an assessment of cardiac work. This initial examination of PV loops from a single-ventricle decapod crustacean demonstrates the utility of this technique to further elucidate the cardiac mechanics and energetics of this system, and in particular during times of physiological stress.

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“…88 PDE5'in, sıçan pulmoner arterlerinde akciğer direncini kontrol ettiği ifade edilmiştir. 89 Son zamanlarda köpek, sıçan ve fareler üzerinde yapılan çalışmalarda, PDE5'in beta (β) reseptörleri aracılığı ile kardiyak yanıtları düzenlediği gösterilmiştir. 90 85-kDa PDE5 esas insan plateletlerinde ifade edilmiş ve plateletlerin ana cGMP-PDE hidrolitik aktivitesiyle temsil edildiği ortaya çıkarılmıştır.…”

Section: Dağılımunclassified

Phosphodiesterase Enzymes and Inhibitors: Review

Tuğrak¹,

Küçükoğlu²

2016

Turkiye Klinikleri J Pharm Sci

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Ö ÖZ ZE ET T Siklik nükleotid fosfodiesteraz enzimleri, vücutta her dokuda ve hücrede bulunabilen enzimlerdir. cAMP ve cGMP'yi hidroliz ettikleri için hücre sinyallerinde önemli rol oynarlar. PDE süper ailesi PDE1-PDE11 arasında olmak üzere 11 tanedir. Memeli hücrelerinde her bir aile 20'den fazla gen vermek için birdört farklı gen taşımaktadır. Bu genler 50'den fazla farklı PDE proteinini kodlarlar. PDE enzimleri içerisinde özellikle PDE1 ve PDE6 iyi karakterize edilmiş izozimlerdir. PDE'ler hücre ve dokularda spesifik dağılım gösteren enzimlerdir. Vücudun farklı doku ve organlarında bulunan PDE enzimleri farklılık gösterir. Bu sayede çeşitli hücre fonksiyonlarında farklı fizyolojik olaylara aracılık edebilirler. PDE izoenzimlerinin hücre ve doku fonksiyonlarına özel katkıları ve patofizyolojik düzenlenmeleri bugün önemli bir araştırma alanı oluşturmaktadır. Bu durum, etkileri henüz tam olarak belirlenmediği için özellikle PDE7-PDE11 gibi yeni PDE ailelerini daha çok ilgilendirmektedir. İnflamasyon, nörodejenerasyon ve kanser gibi birçok patolojik durumda meydana gelen değişiklikler, hücre içi sinyallerle ilgili PDE'lerin serbestleşmesini, bu patolojilerin önlenmesini, ayrıca bu tür patolojik durumların tedavisinde gözlemle-nen zorlukları açıklayabilir. Bu konularda yapılacak araştırmalar sonucu elde edilecek bulgular henüz kesin tedavisi bulunmayan hastalıkların tedavisinde yeni gelişmelere yol açabilir. Bu çalışmada, PDE enzimlerinin özellikleri, vücutta bulundukları doku ve organlar ile patofizyolojik olaylardaki rolleri açık-lanmış, ilaveten PDE inhibitörü ilaçlar anlatılmıştır. Ayrıca yeni geliştirilen ve ruhsatlandırma çalışmaları devam eden PDE inhibitörü bileşikler hakkında da bilgi verilmiştir.A An na ah ht ta ar r K Ke el li im me el le er r: : Fosfodiesteraz inhibitörleri; 2',3'-siklik AMP; 2',3'-siklik GMP A AB BS ST TR RA AC CT T Cyclic nucleotide phosphodiesterase enzymes can be found in every tissue and cell in the body. They play an important role in cell signaling because they hydrolyze cAMP and cGMP. PDE superfamily is 11 units, including PDE1-PDE11. Each family in mammalian cells encompasses 1 to 4 distinct genes, to give more than 20 genes. These genes encode more than 50 different PDE proteins. PDE enzymes in particular PDE1 and PDE6 are isozymes have been well characterized. PDEs are enzymes exhibiting specific distribution in cells and tissues. PDE enzymes located in different tissues and organs of the body vary. In this way, they can mediate different physiological events in various cell functions. Today, private contributions and pathophysiological regulations of PDE isoenzymes in cell and tissue functions constitute an important research field. This situation is more relevant for especially new PDE families such as PDE7-PDE11, because their effects have not been fully determined. Changes that occurs in many pathological situations such as inflammation, neurodegeneration and cancer, may explain the liberalization of PDEs related to the intracellular signaling as well as prevention of th...

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Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease

Abstract: Pressure-area analysis should provide a useful modality with which to assess cardiovascular dynamics in pediatric patients with congenital heart disease in more detail and should thus help improve the management of patients with this disease.

Cited by 42 publications

References 38 publications

Ventricular–Vascular Stiffening in Patients With Repaired Coarctation of Aorta

Ventricular–Vascular Stiffening in Patients With Repaired Coarctation of Aorta

Assessment of the pressure–volume relationship of the single ventricle of the grass shrimp, Palaemonetes pugio

Phosphodiesterase Enzymes and Inhibitors: Review

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