Assessment of Central Visual Function in Patients with Retinitis Pigmentosa

Fujiwara, Kohta; Ikeda, Yasuhiro; Murakami, Yusuke; Tachibana, Tetsuya; Funatsu, Jun; Koyanagi, Yoshito; Nakatake, Shunji; Yoshida, Noriko; Nakao, Shintaro; Hisatomi, Toshio; Yoshitomi, Takeshi; Ishibashi, Tatsuro; Sonoda, Koh Hei

doi:10.1038/s41598-018-26231-9

Cited by 21 publications

(21 citation statements)

References 34 publications

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“…The main contribution of this work lies in the separation of the classical and quantum optimisation necessary for the saturation of the quantum Cramér-Rao bound. In the same year, Fujiwara addressed also the same problem, but limited to pure states [67,68]. He also addressed the theory of multiparameter estimation for pure states based on the RLD [69,70].…”

Section: Multi-parameter Quantum Metrologymentioning

confidence: 99%

Multi-parameter quantum metrology

Szczykulska

Baumgratz

Datta

2016

Advances in Physics: X

250

260

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The simultaneous quantum estimation of multiple parameters can provide a better precision than estimating them individually. This is an effect that is impossible classically. We review the rich background of quantum-limited local estimation theory of multiple parameters that underlies these advances. We discuss some of the main results in the field and its recent progress. We close by highlighting future challenges and open questions. PACS: 06.20.Dk Measurement and error theory, 03.65.Ta Foundations of quantum mechanics; measurement theory, 03.67.-a Quantum information, 42.50.-p Quantum optics

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Section: Multi-parameter Quantum Metrologymentioning

confidence: 99%

Multi-parameter quantum metrology

Szczykulska

Baumgratz

Datta

2016

Advances in Physics: X

250

260

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“…Variables of central retinal sensitivity consisted of the best-corrected visual acuity (BCVA), the averages of the visual sensitivities (dB) of the central 4 points (foveal sensitivity [FS]) [22] and the central 12 points (macular sensitivity [MS]) [22] of the 10-2 Program of the HFA and mean deviation (MD), as described in Fig 1. The BCVA was measured using a Landolt decimal visual acuity chart (TCU-500; Fuji Kogaku, Tokyo, Japan or VC-60; Takagi Seiko, Nakano, https://doi.org/10.1371/journal.pone.0232700.g001…”

Section: Central Retinal Sensitivitymentioning

confidence: 99%

The qualitative assessment of optical coherence tomography and the central retinal sensitivity in patients with retinitis pigmentosa

et al. 2020

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To analyze the relationships between qualitative and quantitative parameters of spectraldomain optical coherence tomography (SD-OCT) and the central retinal sensitivity in patients with retinitis pigmentosa (RP). Materials and methods Ninety-three eyes of 93 patients were finally enrolled, with a median age (quartile) of 58 (24.5) years. We assessed the patients using SD-OCT and the 10-2 program of a Humphry Field Analyzer (HFA). As a qualitative parameter, two graders independently classified the patients' SD-OCT images into five severity grades (grades 1-5) based on the severity of damage to the photoreceptor inner and outer segments (IS/OS) layer. As quantitative parameters, we measured the IS-ellipsoid zone (IS-EZ) width, IS/OS thickness, outer nuclear layer (ONL) thickness, central macular thickness (CMT, 1 and 3 mm) and macular cube (6 × 6 mm) volume and thickness. The central retinal sensitivity was defined by the best-corrected visual acuity (BCVA; logMAR), average sensitivities of the central 4 (foveal sensitivity [FS]) and 12 (macular sensitivity [MS]) points of the HFA 10-2 program and the mean deviation (MD) of the 10-2 program. Spearman's correlation was used to assess the association between both qualitative and quantitative parameters and variables of the central retinal sensitivity. In addition, we performed a multiple regression analysis using these parameters to identify the parameters most strongly influencing the central retinal sensitivity. Results The IS/OS severity grade was significantly correlated with the BCVA (ρ = 0.741, P < 0.001), FS (ρ = −0.844, P < 0.001), MS (ρ = −0.820, P < 0.001) and MD (ρ = −0.681, P < 0.001) and showed stronger correlations to them than any other quantitative parameters including the IS-EZ width, IS/OS thickness, ONL thickness, CMTs and macular cube volume/thickness. Furthermore, a step-wise multiple regression analysis indicated that the IS/OS severity grade was more strongly associated with the BCVA (β = 0.659, P < 0.001), FS (β = −0.820,

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“…The mean deviation (MD) and averaged retinal sensitivity at the central 4 or 12 points were obtained as described previously. 15 , 16 The perimetry tests were adopted within 6 months before and after blood collection.…”

Section: Methodsmentioning

confidence: 99%

Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa

Okita

Murakami

Shimokawa

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose Retinal degeneration involves neuroinflammation, and pro-inflammatory cytokines/chemokines are markedly increased in the eyes of patients with retinitis pigmentosa (RP). In this study, we investigated the changes of serum cytokines/chemokines in RP, and their relationships with visual parameters. Methods Forty-five consecutive patients with typical RP aged 20 to −39 years and 28 age-matched and gender-matched controls were included. Fifteen cytokines (interleukin [IL]-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, 1L-15, IL-17, IL-23, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α, TNF-β) and 9 chemokines (eotaxin, growth-related oncogene [GRO]-α, I-309, IL-8, IFN-γ-inducible protein [IP]-10, monocyte chemotactic protein [MCP]-1, MCP-2, regulated activation normal T-cell expressed and secreted [RANTES], and thymus and activated regulated chemokine [TARC]) in the serum were simultaneously measured by a multiplexed immunoarray (Q-Plex). Relationships between these cytokines/chemokines and indices of central vision, such as visual acuity (VA), the values of static perimetry tests (Humphrey Field analyzer, the central 10-2 program), and optical coherence tomography measures were analyzed in the patients with RP. Results Among the 15 cytokines and 9 chemokines, serum IL-8 and RANTES levels were significantly increased in patients with RP compared with controls (IL-8: P < 0.0001; RANTES: P < 0.0001). Among the elevated cytokines/chemokines, the levels of IL-8 were negatively correlated with VA (ρ = 0.3596 and P = 0.0165), and the average retinal sensitivity of four central points (ρ = −0.3691 and P = 0.0291), and 12 central points ( ρ = −0.3491 and P = 0.0398), as well as the central subfield thickness ( ρ = −0.3961 and P = 0.0094), and ellipsoid zone width ( ρ = −0.3841 and P = 0.0120). Conclusions Peripheral inflammatory response may be activated and serum IL-8 levels are associated with central vision in patients with RP.

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Assessment of Central Visual Function in Patients with Retinitis Pigmentosa

Cited by 21 publications

References 34 publications

Multi-parameter quantum metrology

Multi-parameter quantum metrology

The qualitative assessment of optical coherence tomography and the central retinal sensitivity in patients with retinitis pigmentosa

Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa

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