Assessment of cyclohexanone toxicity in inhalation-exposed F344 rats and B6C3F1 mice: applications in occupational health

Lim, Cheol Hong; Lee, Yong Hoon; Kim, Yong Soon; Choi, Hyun Sung; Seo, Dong Seok

doi:10.1080/08958378.2018.1512689

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…Cyclohexanone, on the other hand, is used as a PVC adhesive and can potentially induce contact dermatitis . Cyclohexanone inhalation also induced hepatotoxicity and nephrotoxicity in rats . This compound was detected in several other studies that investigated emissions and odors from polymer-based products. ,, …”

Section: Resultsmentioning

confidence: 82%

“…It was not possible to reproduce how the registrants derived the cyclohexanone DNELs from the reported data on the ECHA website . Considering a recent study on cyclohexanone toxicity upon inhalation in rodents, which was not considered by the registrants, we derived long-term DNELs for workers and the general population of 8.1 and 1.4 mg·m –3 , respectively (see Table S4 and accompanying text; the latter DNEL is also indicated in Figure ). The corrected DNEL of 1.4 mg·m –3 was exceeded by up to 31-fold during the first few minutes of wearing, and still by more than 10 times after 2 h. As costume masks may be worn repeatedly for several hours, the corrected long-term DNEL is considered more appropriate than the acute DNEL that reflects a single use exposure.…”

Section: Resultsmentioning

confidence: 99%

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Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Even

Roloff

Lüttgert

et al. 2021

Chem. Res. Toxicol.

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Plastic costume masks regularly exhibit unpleasant odors that may be associated with the emissions of volatile organic compounds (VOCs). Upon inhalation, VOCs might adversely affect the wearer's health if the exposure exceeds regulatory threshold values. The VOCs emitted from a selection of costume masks (n = 12) were characterized semiquantitatively with a screening method based on GC/MS measurements in dynamic headspace sampling mode. Furthermore, odors associated with the masks were evaluated by a sensory panel. Two masks emitted particularly high concentrations of ethylbenzene, xylenes, and cyclohexanone and exhibited the most intense and unpleasant odors, which were described as rubber-like, pungent, and leather-like. To simulate and assess the inhalation exposures for wearers of these masks, an innovative experimental setup based on a doll's head was developed, with sampling of emitted volatiles on adsorption material and subsequent analysis by thermal desorption−GC/MS. The measured inhalable concentrations of cyclohexanone exceeded the derived no-effect level (DNEL) for systemic effects on the general population over several hours of wearing, and also after repeated use. Importantly, the cyclohexanone DNEL was reevaluated in relation to a recent study on inhalation toxicity in rodents and was found to be significantly lower (1.4 mg•m −3 ) compared to the industry-derived values (10−20 mg•m −3 ), thus aggravating the health risks associated with inhalation exposure from some of the costume masks tested. Finally, a comparison of the inhalable concentrations derived from the simulated exposure assessments with those derived from measurements in miniaturized emission test chambers indicate that microchambers represent a useful tool for high-throughput analysis. The influences of temperature and inhalation/exhalation flow rates on VOC exposures were also studied.

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Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Even

Roloff

Lüttgert

et al. 2021

Chem. Res. Toxicol.

View full text Add to dashboard Cite

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“…According to reports, cyclohexanone is a low-toxicity chemical with a pungent odor, which makes it easier to be noticed and stay away. 58–60 …”

Section: Resultsmentioning

confidence: 99%

“…According to reports, cyclohexanone is a low-toxicity chemical with a pungent odor, which makes it easier to be noticed and stay away. [58][59][60] Recyclability. The stability of the catalyst is essential for practical applications.…”

Section: Removal Performancementioning

confidence: 99%

Cu₂O nanoparticles anchored on carbon for the efficient removal of propofol from operating room wastewater via peroxymonosulfate activation: efficiency, mechanism, and pathway

et al. 2021

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“…Bioenergetic components were found in C sample. Cyclohexanone (4.44%) is a flammable liquid, explosive mixture with air, and a viscous solvent for piston-type aviation lubricants (Lim et al, 2018). 1-Tetradecene (0.77%) is liquid fuel.…”

Section: Resultsmentioning

confidence: 99%

Functional nano-catalyzed pyrolyzates from branch of Cinnamomum camphora

Meng

Zhang

et al. 2019

Saudi Journal of Biological Sciences

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Cinnamomum camphora is an excellent tree species for construction of forest construction of Henan Province, China. The diverse bioactive components of nano-catalyzed pyrolyzates form cold-acclimated C. camphora branch (CCB) in North China were explored. The raw powder of CCB treated with nano-catalyst (Ag, NiO, 1/2Ag + 1/2NiO) were pyrolyzed at two temperatures (550 °C and 700 °C), respectively. The main pyrolyzates are bioactive components of bioenergy, biomedicines, food additive, spices, cosmetics and chemical, whose total relative contents at 550 °C pyrolyzates are higher than those at 700 °C pyrolyzates. There are abundant components of spices and biomedicine at 550 °C pyrolyzates, while more spices and food additive at 700 °C pyrolyzates. At 550 °C, the content of biomedicine components reaches the highest by 1/2Ag + 1/2NiO nanocatalysis, while the contents of spices and food additive components reach the highest by NiO nanocatalysis. At 700 °C, the content of bioenergy components reaches the highest by 1/2Ag + 1/2NiO nanocatalysis, and the content of cosmetics components reaches the highest by Ag nanocatalysis. The findings suggested that the branch of the cold-acclimated C. camphora have the potential to develop into valued-added products of bioenergy, biomedicine, cosmetics, spices and food additive by nanocatalysis.

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Assessment of cyclohexanone toxicity in inhalation-exposed F344 rats and B6C3F1 mice: applications in occupational health

Cited by 7 publications

References 5 publications

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Cu₂O nanoparticles anchored on carbon for the efficient removal of propofol from operating room wastewater via peroxymonosulfate activation: efficiency, mechanism, and pathway

Functional nano-catalyzed pyrolyzates from branch of Cinnamomum camphora

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Assessment of cyclohexanone toxicity in inhalation-exposed F344 rats and B6C3F1 mice: applications in occupational health

Cited by 7 publications

References 5 publications

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks

Cu2O nanoparticles anchored on carbon for the efficient removal of propofol from operating room wastewater via peroxymonosulfate activation: efficiency, mechanism, and pathway

Functional nano-catalyzed pyrolyzates from branch of Cinnamomum camphora

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Product

Resources

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Cu₂O nanoparticles anchored on carbon for the efficient removal of propofol from operating room wastewater via peroxymonosulfate activation: efficiency, mechanism, and pathway