Assessment of Diffuse Thyroid Disease by Strain Ratio in Ultrasound Elastography

Yang, Zhi; Zhang, Haixian; Wang, Kun; Cui, Guanghe; Fu, Fangmeng

doi:10.1016/j.ultrasmedbio.2015.07.012

Cited by 25 publications

(21 citation statements)

References 18 publications

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“…Yang et al investigated the utility of sonoelastography in diffuse thyroid diseases (13). They demonstrated significant differences in thyroid hardness between different diffuse thyroid diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In 2015, Yang et al (13) reported no statistically significant difference between the CG and hyperthyroidism groups, but they regarded all the patients with hyperthyroidism in one group. In our study, we created a special group that included only GD and excluded other entities presented as hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…In 2015, Yang and et al demonstrated that RTE and strain ratio elastography may be useful in differentiating SAT from HT (13). However, the number of patients in their study was very small and they did not include patients with GD.…”

Section: Graves' Diseasementioning

confidence: 99%

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Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Korkmaz¹,

Baki²,

Köse³

et al. 2017

Iran J Radiol

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Objectives: The main purpose of the present study was to determine the efficacy of real-time elastography (RTE) and strain elastography (STE) in the diagnosis of different thyroid diseases. We also aimed to calculate the cut-off points for the differential diagnosis of subacute thyroiditis (SAT), Graves' disease (GD), and Hashimoto's thyroiditis (HT), which have a similar B-mode sonographic appearance. Patients and Methods: A total of 24 patients with GD (10.9%), 94 patients with HT (42.7%), 20 patients with SAT (9.1%), and 82 individuals with normal healthy thyroids (37.3%) were included. Grayscale ultrasound evaluation of thyroid glands was performed with standard transverse and longitudinal planes before sonoelastography. Results:The strain ratios (SRs) (mean ± standard deviation) of patients with GD, HT, and SAT, and the control group (CG) were 14.7 ± 14.8, 8.4 ± 9.6, 23.2 ± 10.8, and 1.37 ± 0.8, respectively. The cut-off points of strain elastography of the patients with GD, HT, and SAT to the CG were 2.69 (sensitivity 92%, specificity 90%, area under the curve (AUC) 0.983; 95% CI), 2.18 (sensitivity 100%, specificity 85%, AUC 0.898), and 5.54 (sensitivity 100%, specificity 100%, AUC 1.000; 95% CI), respectively. The cut-off point of the strain ratios (SR) of the total amount of patients with HT and GD to SAT was 14.79 (sensitivity 80%, specificity 85%, AUC 0.869; 95% CI). Conclusion: Statistically significant differences were noted in the SR values and elasticity scores of the three experimental groups, and the CG. The elasticity scores of the SAT and HT groups were not significantly different from those of the GD group. The diagnostic performance of strain ratio elastography (P < 0.0001) was higher than that of real time elastography (P < 0.001). In terms of differentiating diagnosis, ES could differentiate SAT from HT, but it had no value in differentiating GD from HT and SAT. We also found statistically significant SRs for the differential diagnosis of SAT from GD and HT. Strain elastography could be a useful method for the differential diagnosis of SAT from a healthy population or from other types of thyroiditis such as GD and HT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Korkmaz¹,

Baki²,

Köse³

et al. 2017

Iran J Radiol

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“…SR values ranked in ascending order were control group, hyperthyroidism group, Hashimoto's thyroiditis group, SGT group. There were statistically significant (p<0.05) differences in thyroid hardness between groups with different diffuse thyroid diseases [29].…”

Section: Color Doppler Imagingmentioning

confidence: 89%

“…Yang et al in their study found that the strain ratio (SR) values (calculated by comparing the strain in the thyroid nodule to the sternocleiodomastoid muscle in the same image) ranked in ascending order, control group < hyperthyroidism group < Hashimoto's thyroiditis group < subacute thyroiditis group with statistically significant difference (p<0.05) between groups and that it is feasible to assess diffuse thyroid disease with strain ratios obtained with ultrasound elastography [29]. In clinical practice, elastography is usually not used for these indications.…”

Section: Diffuse Thyroid Disease (Dtd)mentioning

confidence: 99%

Thyroid Ultrasound: State of the Art Part 1 – Thyroid Ultrasound reporting and Diffuse Thyroid Diseases

et al. 2017

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Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam.

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Reliability of ultrasound real‐time tissue elastography in evaluating swallowing‐related muscle elasticity and effects of swallowing exercises

Ota,

Madokoro,

Shimizu

et al. 2024

Sonography

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IntroductionEvaluating swallowing function, essential for eating, is necessary to detect functional decline, enabling the provision of effective interventions. There is a growing demand for a simple method for evaluating swallowing dynamics. Conventional methods of evaluating swallowing function, such as the fibreoptic endoscopic evaluation of swallowing or videofluoroscopic swallowing study, are highly invasive and require specific equipment only available at certain hospitals, making it difficult for older adults to receive convenient evaluations. Therefore, we used ultrasound real‐time tissue elastography (RTE), a low‐invasive method, to evaluate tissue elasticity as the strain ratio (SR). This study primarily aimed to verify whether RTE can evaluate the elasticity of swallowing‐related muscles (SRMs) and determine intra‐ and inter‐rater reliabilities. The secondary aim was to investigate the effect of swallowing exercises, such as head‐lifting exercises, on SRM elasticity.MethodsIntraclass correlation coefficients for SR were calculated using ultrasound B‐mode images to determine the reliability of SRM elasticity. SRs before and after the Shaker swallowing exercise were compared using the Wilcoxon signed‐rank test.ResultsHigh ICCs for intra‐ and inter‐rater reliabilities were obtained for all targeted SRMs. SR after the Shaker exercise indicated a significant decrease in the geniohyoid muscle and both sides of the digastric muscles, whereas both sides of the masseter exhibited no changes.ConclusionRTE can be used as a novel simple and non‐invasive method for assessing and capturing differences in SRs of SRMs after light exercise. Further research may develop a relationship with swallowing function in patients with dysphagia or older individuals.

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Assessment of Diffuse Thyroid Disease by Strain Ratio in Ultrasound Elastography

Cited by 25 publications

References 18 publications

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Thyroid Ultrasound: State of the Art Part 1 – Thyroid Ultrasound reporting and Diffuse Thyroid Diseases

Reliability of ultrasound real‐time tissue elastography in evaluating swallowing‐related muscle elasticity and effects of swallowing exercises

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