Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT

Inoue, Takamitsu; Kudo, Masatoshi; Komuta, Mina; Hayaishi, Sosuke; Ueda, Takako; Takita, Masahiro; Kitai, Satoshi; Hatanaka, Kinuyo; Yada, Norihisa; Hagiwara, Satoru; Chung, Hobyung; Sakurai, Toshiharu; Ueshima, Kazuomi; Sakamoto, Michiie; Maenishi, Osamu; Hyodo, Toru; Okada, Masahiro; Kumano, Seishi; Murakami, Takamichi

doi:10.1007/s00535-012-0571-6

Cited by 81 publications

(71 citation statements)

References 23 publications

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“…6 -9 Recent reports indicate that gadoxetic acid-enhanced hepatocyte-phase (HP) images demonstrate hypovascular HCCs as hypointense nodules. 10,11 Adding hepatobiliary-phase imaging to conventional dynamic MR imaging (precontrast, arterial, and portal venous phases) increases the sensitivity of HCC diagnosis by 11% and the negative predictive value (NPV) for the classification of premalignant lesions (high grade dysplastic nodules) and hypovascular HCCs (early HCCs) by 33% compared with those obtained by dynamic MR imaging without hepatobiliary-phase imaging. 12 Although conventional clinical practice guidelines do not include hepatobiliary MR contrast agents, there is an emerging demand to use gadoxetic acid for the diagnosis of HCC, especially for early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Added Value of a Gadoxetic Acid-enhanced Hepatocyte-phase Image to the LI-RADS System for Diagnosing Hepatocellular Carcinoma

et al. 2016

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Purpose: We investigated the added value of the hypointensity on hepatocyte-phase (HP) imaging of gadoxetic acid-enhanced MRI (EOB-MRI) in the 2014 version of the Liver Imaging Reporting and Data System (LI-RADS) for distinguishing hepatocellular carcinoma (HCC) from benign hepatic lesions in patients with chronic liver disease.Methods: We retrospectively evaluated targeted lesions (111 HCCs, 28 benign hepatic lesions) of 139 patients (101 men, 38 women; aged 18 to 89 years, mean age, 68 « 11 years) with chronic liver disease. EOB-MRI and dynamic contrast-enhanced computed tomography (CECT) were performed within 3 months. Two abdominal radiologists independently reviewed 3 imaging datasets: (1) EOB-MRI without an HP image using the LI-RADS system (MR imaging without HP); (2) EOB-MRI with an HP image using a modified version of the LI-RADS system in which hypointensity on the HP image was used as an additional major criterion of malignancy (MR imaging with HP); and (3) dynamic contrast-enhanced computed tomography (CECT) images using the LI-RADS system. We evaluated intra-and inter-reader agreement with kappa statistics along with 95% confidence intervals and compared diagnostic sensitivity and specificity of the 3 imaging datasets with McNemar's test.Results Conclusion: The use of an HP image from EOB-MRI as an additional major criterion improved the sensitivity of LI-RADS to distinguish HCCs from benign hepatic lesions while retaining high specificity.

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Section: Introductionmentioning

confidence: 99%

Added Value of a Gadoxetic Acid-enhanced Hepatocyte-phase Image to the LI-RADS System for Diagnosing Hepatocellular Carcinoma

et al. 2016

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“…Although this study was not intended to determine the cause for the increase in early detection rates of HCC and treatment with local therapy, the sensitivity and accuracy of DCP and lens culinaris agglutinin-reactive fraction of AFP diagnostic systems have been improved (33). The diagnostic ability of magnetic resonance imaging for HCC has significantly improved through the use of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (34). Hepatic fibrosis and liver function have also improved after the introduction of nucleot(s)ide analogues (35,36).…”

Section: Discussionmentioning

confidence: 99%

Time trends of clinical characteristics in hepatocellular carcinoma patients with chronic hepatitis B virus infection: A field survey between 2000 and 2012

Amano

Kawaguchi

Kuromatsu

et al. 2014

Molecular and Clinical Oncology

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Abstract. The hepatitis B virus (HBV) carrier rate has decreased in Japan; however, the incidence of HBV infection among hepatocellular carcinoma (HCC) patients has not decreased accordingly. In this study, we aimed to assess the time trends of the clinical characteristics in HCC patients with chronic HBV infection. Between 2000 and 2012, we enrolled a total of 156 HCC patients with chronic HBV infection in our field survey. The HCC risk was evaluated using the HCC prediction score, which is constructed from the characteristics of age, presence of liver cirrhosis and serum levels of albumin, bilirubin and HBV DNA. Lifestyle factors and the presence of diabetes mellitus were also evaluated. The time trends of patient characteristics were analyzed using the Jonckheere-Terpstra proportion trend test. Among HCC patients with chronic HBV infection, the proportion of patients at high risk according to the HCC prediction score significantly decreased during the study period (P=0.0005). Similarly, the proportion of patients with liver cirrhosis, ≤3.5 g/dl serum albumin level, >4 log copies/ml serum HBV DNA level and ≥60 g/day alcohol intake were also significantly decreased. The proportion of male and obese patients was not significantly altered, whereas the proportion of elderly (≥65 years) and diabetic patients tended to increase during the study period (P=0.0654 and P=0.0528, respectively). In this study, we analyzed the time trends of the clinical characteristics in HCC patients with chronic HBV infection and demonstrated that aging and diabetes mellitus may be involved in the hepatocarcinogenesis in patients with chronic HBV infection.

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“…It is also reported that Gd-EOB-DTPA-enhanced MRI is the most useful imaging technique for the detection of early HCC [9,23,24]. Accordingly, the opportunity to find small HCCs has increased since Gd-EOB-DTPA-enhanced MRI became available.…”

Section: Discussionmentioning

confidence: 99%

“…One of the reasons is that it has the highest sensitivity for detecting HCC [9,10,22,23,24,33] as described above, and another is the clear depiction of tumors and surrounding intrahepatic landmarks [30], which makes the positional registration accurate and easy.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonography Fusion Imaging System Increases the Chance of Radiofrequency Ablation for Hepatocellular Carcinoma with Poor Conspicuity on Conventional Ultrasonography

et al. 2013

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Objectives: To investigate the usefulness of the ultrasonography (US) fusion imaging system for radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: Since the US fusion imaging system became available in 2010, we have conducted RFA with this system in all cases. The characteristics of 75 patients with 120 HCCs and 89 patients with 123 HCCs who underwent RFA before the introduction of this system (period A) and after it (period B), respectively, were retrospectively compared. Results: Significant difference in the characteristics of the patients and HCCs between the two periods was found only in the proportion of HCCs with poor conspicuity on grayscale US treated with RFA (1.7%, 2/120 for period A vs. 15.4%, 19/123 for period B, p < 0.01). Among the 19 HCCs with poor conspicuity on grayscale US for period B, 5 and 9 HCCs were identified on grayscale US and contrast-enhanced US, respectively, by the use of the US fusion imaging system, whereas the 5 remaining undetectable HCCs were treated by using the system in conjunction with reference images displayed side-by-side with grayscale US. Conclusion: Since the introduction of the US fusion imaging system, it has become possible to perform RFA for HCCs with poor conspicuity on grayscale US.

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Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT

Cited by 81 publications

References 23 publications

Added Value of a Gadoxetic Acid-enhanced Hepatocyte-phase Image to the LI-RADS System for Diagnosing Hepatocellular Carcinoma

Added Value of a Gadoxetic Acid-enhanced Hepatocyte-phase Image to the LI-RADS System for Diagnosing Hepatocellular Carcinoma

Time trends of clinical characteristics in hepatocellular carcinoma patients with chronic hepatitis B virus infection: A field survey between 2000 and 2012

Ultrasonography Fusion Imaging System Increases the Chance of Radiofrequency Ablation for Hepatocellular Carcinoma with Poor Conspicuity on Conventional Ultrasonography

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