Assessment of histamine‐releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells

Asero, Riccardo; Lorini, M.; Chong, Sie-Uen; Zuberbier, Torsten; Tedeschi, A.

doi:10.1111/j.1365-2222.2004.01997.x

Cited by 46 publications

(41 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frequency of ASST-positive results varied from 24.7 to 65.5%, in accordance with previous data in the literature [14,15]. The number of patients undergoing ASST varied in the studies from 45 to 228.…”

Section: Resultssupporting

confidence: 78%

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Although some authors have already evaluated the predictive value of various parameters regarding the duration of chronic spontaneous urticaria (CSU), it remains uncertain which ones have importance in clinical practice as prognostic factors that indeed enable prediction. Similarly, some authors have investigated parameters that might be related to severe cases of CSU. However, the results of studies evaluating several parameters as markers of disease severity are fragmented. Thus, we performed a systematic review to summarize the findings of studies investigating the parameters associated with CSU duration and severity. Methods: Two authors independently searched PubMed until June 2012 for observational retrospective or prospective studies addressing clinical or laboratory parameters associated with disease duration or severity in CSU patients. Results: We found 1,136 potentially relevant published papers related to the subject, 34 of which were included in the systematic review. A total of 16, 6 and 12 articles evaluated CSU parameters on severity, duration or both, respectively. Conclusions: Our findings suggest that disease severity might predict CSU duration. Similarly, evidence suggests that plasma levels of prothrombin fragment 1 + 2, D-dimer and C-reactive protein may function as markers of CSU severity.

show abstract

Section: Resultssupporting

confidence: 78%

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Asero et al [12] have published a comparison between the in vitro histamine-releasing assays on mast cells and basophils and the in vivo technique of ASST in a cohort of patients. They concluded that, although patients with a strongly positive ASST had detectable in vitro histamine-releasing factors, the variability of the in vitro histamine-releasing tests was high, and sensitivity of detection of endogenous-releasing factors was lower than in the in vivo ASST.…”

Section: Diagnosis Of Autoimmune Urticariamentioning

confidence: 99%

“…Further work suggested that, in most sera, functional anti-FcεRIα did not compete with IgE for the receptor at the cell surface, but, in a few patients, competitive binding occurred [7]. Functional anti-FcεRIα in a proportion of patients with chronic spontaneous urticaria has been demonstrated by independent laboratories acting on basophils [8], a rat basophil leukemia cell line [9], and on mast cells [10][11][12].…”

Section: An Endogenous Factor Responsible For Chronic Urticaria In Somentioning

confidence: 99%

Autoimmunity and complement in the pathogenesis of chronic urticaria

Marsland

2006

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Chronic urticaria is a debilitating skin disease that is believed to have an underlying autoimmune etiology in 35% to 50% of cases. Patients with autoimmune urticaria have functional antibodies in their sera that release histamine from basophils and mast cells. The C5a component of complement is required for mast cell degranulation in this process and at least augments basophil histamine release. In this article, the evidence that is key to our understanding of autoimmunity and complement in the pathogenesis of a subset of patients with chronic urticaria is outlined. Some of the issues in testing for and treating autoimmune urticaria are discussed.

show abstract

“…The basophil histamine release assay (HRA) currently remains the "gold standard" for confirmation of functional antibodies in the serum of patients with CU [9]. The HRA used by some authors is less sensitive than ASST in detection of patients with histamine releasing factors in their blood [10]. Furthermore, HRA is time consuming and cumbersome to perform.…”

Section: Introductionmentioning

confidence: 99%