Assessment of Intraventricular Time Differences in Healthy Children Using Two-Dimensional Speckle-Tracking Echocardiography

Klitsie, Liselotte M.; Roest, Arno A.W.; Hulst, Annelies E. van der; Stijnen, Theo; Blom, Nico A.; Harkel, Arend D J Ten

doi:10.1016/j.echo.2013.03.006

Cited by 45 publications

(84 citation statements)

References 31 publications

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“…7,8,11-13,17,18,21,29-31,34,36-38,40,42,43,48 The normal mean values of systolic LSr varied from -0.41 to -2.59 (mean -1.20, 95% CI -0.96 to -1.44). The normal mean values of early diastolic LSr varied from 1.60 to 3.15 (mean 2.23, 95% CI 1.89 to 2.53), and the normal mean values of late diastolic LSr for varied from 0.40 to 2.41 (mean 0.80, 95% CI 0.64 to 0.95).…”

Section: Resultsmentioning

confidence: 96%

“…LV free wall from the apical 4- chamber views was reported in 9 of 43 data sets ( n=716 children). 7,8,16,17,28-30,34,36 The normal mean values of FW SL varied from -17.00% to -23.4 % (mean -20.2%, 95% CI -19.2% to -22.2%). Between-study heterogeneity was evidenced by a Cochran's Q statistic of 458 (P < 0.0001) and inconsistency by an I 2 value of 96.3%.…”

Section: Resultsmentioning

confidence: 96%

“…Forty-one datasets with 2084 patients were eligible for the meta-analysis of GLS or LS ; 7-24,26-34,36-49 26 datasets with 1506 patients were eligible for the meta-analysis of GCS or CS , 7,9,11,12,14-20,23,25,26,28-31,33,34,41-44,46,48 and 15 datasets with 1092 patients were eligible for the meta-analysis of GRS or RS. 11,15,16,19,20,23,25,26,28,29,33,41-43,46 The patient characteristics of the included studies are listed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…7,8,10-13,16-19,21,22,28-34,36-38,40,42,43,48 (There were four datasets that reported both the GLS and the LS from the apical 4-chamber view only. 19,28,30,33 ) The normal mean values of LS varied from -15.1% to -24.8% (mean -20.4, 95% CI -19.8% to -21.7%), (Figure 2b).…”

Section: Resultsmentioning

confidence: 99%

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Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis

Levy

Machefsky

Sanchez

et al. 2016

Journal of the American Society of Echocardiography

267

215

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Background The establishment of the range of reference values and associated variations of two-dimensional speckle-tracking echocardiography (2DSTE) derived left ventricular (LV) strain is a prerequisite for its routine clinical adoption in pediatrics. The aims were to perform a meta-analysis of normal ranges of LV global longitudinal, circumferential, and radial strain (GLS, GCS, and GRS) measurements derived by 2DSTE in children and identify confounding factors that may contribute to variances in reported measures. Methods A systematic review was launched in Medline, Embase, Scopus, CINAHL, and Cochrane. Search hedges were created to cover the concepts of pediatrics, speckle-tracking echocardiography, and left heart ventricle. Two investigators independently identified and included studies if they reported the 2DSTE derived LV GLS, GCS or GRS. The weighted mean was estimated by using random-effects with 95% confidence interval (CI), heterogeneity was assessed by the Cochran's Q statistic and the inconsistency index (I2) and publication was evaluated using the Egger test. Effects of demographic (age), clinical, and vendor variables were assessed in a meta-regression. Results The search identified 2325 children from 43 data sets. The reported normal mean values of GLS among the studies varied from -16.7% to -23.6% (mean -20.2%, 95% CI -19.5% to -20.8%), GCS varied from -12.9% to -31.4% (mean -22.3%, 95% CI -19.9% to -24.6%) and GRS, varied from 33.9% to 54.5 % (mean 45.2 95% CI 38.3 to 51.7). 26 studies reported LS only from the apical 4-chamber view with a mean of -20.4%, (95% CI -19.8% to -21.7%). 23 studies reported CS (mean, -20.3%, 95% CI -19.4% to -21.2%) and RS (mean, 46.7%, 95% CI 42.3% to 51.1%) from the short axis view at the mid-ventricular level. A significant apex-to-base segmental longitudinal strain (SLS) gradient (P < .01) was observed in the LV free wall. There was significant between- study heterogeneity and inconsistency (I2 > 94% and P < .001 for each strain measure), which was not explained by age, gender, body surface area, blood pressure, heart rate, frame rate, FR/HR ratio tissue-tracking methodology, location of reported strain value along the strain curve, ultrasound equipment, or software. These metaregression showed that these effects were not significant determinants of variations among normal ranges of strain values. There was no evidence of publication bias (P = .40). Conclusions This study defined reference values of 2DSTE derived LV strain in children on the basis of a meta-analysis. In healthy children, the mean LV global longitudinal strain value is -20.2%, (95% CI -19.5% to -20.8%), mean global circumferential strain -22.3%, (95% CI -19.9% to -24.6%), and mean global radial strain is 45.2%, (95% CI 38.3% to 51.7%). LV segmental longitudinal strain has a stable apex-to-base gradient that is preserved throughout maturations. Although variations among different reference ranges in this meta-analysis were not dependent on differences in demographic, clinical, or vendor para...

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis

Levy

Machefsky

Sanchez

et al. 2016

Journal of the American Society of Echocardiography

267

215

View full text Add to dashboard Cite

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“…La medición de la función ventricular utilizando la ecocardiografía con ST, a juzgar por el número de publicaciones, es cada vez más frecuente y aunque la mayoría de ellas se haya realizado sobre población adulta, en los últimos años han aparecido trabajos en cardiología pediátrica 17,18,19 que dan cuenta de la importancia de esta nueva técnica sobre la evaluación de la función miocárdica en este grupo poblacional por lo que consideramos de gran importancia obtener valores referenciales propios.…”

Section: Discussionunclassified

Estudio de la función miocárdica mediante ecocardiografía con Speckle-Tracking valores normales en una población pediátrica

Alemán

Barrezueta

2015

Rev. Med. UCSG

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ResumenObjetivo: estudiar la deformación miocárdica mediante ecocardiografía con speckle tracking y estimar los valores normales del strain sistólico longitudinal en una población pediátrica sana. Materiales y métodos: se revisaron 100 estudios ecocardiográficos en niños normales con edades entre 5 y 18 años midiendo los valores de la deformación pico sistólica longitudinal, el análisis estadístico usado fue ANOVA. Resultados: la deformación miocárdica longitudinal global promedio fue -22,17 % +-0,39. El grupo que mayor deformación presentó fue el de 10-13 años (-22,62 % +-1,86) p< 0.002 y entre los segmentos de pared, los apicales (-22,86 +-0,70) p<0.005 fueron los que mayor valor alcanzaron. Conclusiones: el estudio establece nuestros valores referenciales de deformación miocárdica longitudinal mediante ecocardiografía con speckle tracking. Los resultados son similares a los publicados por otros autores.PALABRAS CLAVE: ecocardiografía, contracción miocárdica, pediatría. Abstract Objective: to study myocardial deformation using speckle tracking echocardiography and estimating the normal values of longitudinal systolic strain in a healthy pediatric population. Method: 100 echocardiographic studies were reviewed in normal children aged between 5 and 18 measuring the values of peak systolic longitudinal strain. The statistical analysis used was ANOVA. Results: global longitudinal myocardial deformation average was -22.17% + -0.39. The group that presented the greatest deformation was the 10-13 year old children (-22.62% + -1.86) p <0.002 and between the wall segments, the apical (-22.86 + -0.70) p < 0,005 reached the highest value. Conclusions: the study establishes our reference values for longitudinal myocardial deformation using speckle tracking echocardiography. The results are similar to those published by other authors. KEYWORDS: echocardiography, myocardial contraction, pediatrics.Resumo Objetivo: estudo de deformação do miocárdio pela ecocardiografia com speckle tracking e estimação dos valores normais da tensão sistólica longitudinal em uma população pediátrica saudável. Método: foram revisados 100 estudos ecocardiográficos em crianças normais com idades entre 5 e 18 anos medindo os valores da deformação do pico sistólico longitudinal, a análise estatística utilizada foi a ANOVA. Resultados: a média global de deformação longitudinal do miocárdio foi -22,17 % +-0,39. O grupo que apresentou maior deformação foi o de 10-13 anos (-22,62 % +-1,86) p< 0,002 e entre os segmentos da parede, os apicais (-22,86 +-0,70) p<0,005 foram aqueles com o maior valor. Conclusões: o estudo estabelece os nossos valores de referência de deformação longitudinal do miocárdio pela ecocardiografia com speckle tracking. Os resultados são similares aos publicados por outros autores.PALABRAS-CHAVE: ecocardiografia, contração miocárdica, pediatria.

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Cardiac abnormalities in girls with Turner syndrome: ECG abnormalities, myocardial strain imaging, and karyotype–phenotype associations

Noordman

Fejzic

Bos

et al. 2021

American J of Med Genetics Pt A

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Turner syndrome (TS) is a chromosomal condition which is associated with an increased prevalence of cardiac morbidity and mortality. In this cross-sectional study, Minnesotabased electrocardiographic (ECG) abnormalities, aortic dimensions, routine-and myocardial strain echocardiographic parameters, and karyotype-cardiac phenotype associations were assessed in girls with TS. In total, 101 girls with TS (0-18 years) were included.The prevalence of major ECG abnormalities was 2% (T-wave abnormalities) and 39% had minor ECG abnormalities. Dilatation of the ascending aorta (z-score > 2) was present in 16%, but the prevalence was much lower when using TS-specific z-scores. No left ventricular hypertrophy was detected and the age-matched global longitudinal strain was reduced in only 6% of the patients. Cardiac abnormalities seemed more common in patients with a non-mosaic 45,X karyotype compared with other karyotypes, although no statistically significant association was found. Lowering the frequency of echocardiography and ECG screening might be considered in girls with TS without cardiovascular malformations and/or risk factors for aortic dissection. Nevertheless, a large prospective study is needed to confirm our results. The appropriate z-score for the assessment of aortic dilatation remains an important knowledge gap. The karyotype was not significantly associated with the presence of cardiac abnormalities, therefore cardiac screening should not depend on karyotype alone.

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Assessment of Intraventricular Time Differences in Healthy Children Using Two-Dimensional Speckle-Tracking Echocardiography

Cited by 45 publications

References 31 publications

Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis

Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis

Estudio de la función miocárdica mediante ecocardiografía con Speckle-Tracking valores normales en una población pediátrica

Cardiac abnormalities in girls with Turner syndrome: ECG abnormalities, myocardial strain imaging, and karyotype–phenotype associations

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