Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

Doğan, Çağla Serpil; Akman, Sema; Şimşek, Ayşe; Özdem, Sebahat; Çomak, Elif; Gökçeoğlu, Arife Uslu; Kardelen, Fırat; Koyun, Mustafa

doi:10.3109/0886022x.2015.1061301

Cited by 15 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Midwall fractional shortening was the only functional measure associated to concentric left ventricular morphology. Previous studies have linked E/E’ to left ventricular hypertrophy, but only if LVH was considered very pronounced (>97.5 th percentile) 18 and in a smaller analysis unadjusted for age 20 . However, in the presence of LVH, diastolic or systolic dysfunction may play an additional predictive role for future adverse events 21 or outcomes, as longitudinal analysis may reveal.…”

Section: Discussionmentioning

confidence: 95%

Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Doyon

Haas

Erdem

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Children with chronic kidney disease suffer from excessive cardiovascular mortality and early alterations of the cardiovascular system. Tissue doppler imaging is a validated echocardiographic tool to assess early systolic and diastolic cardiac dysfunction. We hypothesized that tissue Doppler velocities would reveal reduced cardiac function in children with chronic kidney disease compared to healthy children. A standardized echocardiographic exam was performed in 128 patients of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) Study aged 6–17 years with an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 . Tissue Doppler measurements included early (E’) and late (A’) diastolic and systolic (S’) velocity at the mitral and septal annulus of the left ventricle. Measured values were normalized to z-scores using published reference data. Predictors of E’/A’, E/E’, S’ and left ventricular mass index (LVMI) were assessed by multiple linear regression analyses. Tissue Doppler E’ was reduced and tissue Doppler A’ increased, resulting in a reduced tissue Doppler E’/A’ ratio (z-score −0.14, p < 0.0001) indicating reduced diastolic function compared to healthy children. Reduced tissue Doppler E’/A’ Z-Scores were independently associated with lower eGFR (p = 0.002) and increased systolic blood pressure (p = 0.02). While E/E’ Z-Scores were increased (Z-score 0.57, p < 0.0001), patients treated with pharmacological RAS blockade but not with other antihypertensive treatments had significantly lower E/E’ and higher E’/A’ Z-Scores. Systolic tissue Doppler velocities were significantly decreased (Z-score −0.24, p = 0.001) and inversely correlated with E/E’ Z-Scores (r = −0.41, p < 0.0001). LVMI was not associated with systolic or diastolic tissue Doppler velocities. Concentric left ventricular hypertrophy showed a tendency to lower S’ in multivariate analysis (p = 0.13) but no association to diastolic function. Concentric left ventricular geometry was significantly associated with lower midwall fractional shortening. In summary, systolic and diastolic function assessed by tissue Doppler is impaired. eGFR, systolic blood pressure and the type of antihypertensive medications are significant predictors of diastolic function in children with CKD. Left ventricular morphology is largely independent of tissue Doppler velocities. Tissue Doppler velocities provide sensitive information about early left ventricular dysfunction in this population.

show abstract

Section: Discussionmentioning

confidence: 95%

Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Doyon

Haas

Erdem

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The cut-off value of the E/E' ratio to define LVDD may have influenced the prevalence in our study. There were several studies in which CKD children have worse LVDD than healthy children, and LVDD worsened as Data are presented as the mean ± standard deviation, as the median with the full range given in the parentheses, or as the number of patients with the percentage given in parentheses CKD progressed [30,32]. However, the absence of a consensus standard method for defining LVDD affected the lack of interpretation of LVDD clinical significance in pediatric CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study

et al. 2020

View full text Add to dashboard Cite

Background Cardiovascular disease (CVD) is the most common cause of mortality in pediatric chronic kidney disease (CKD) patients. Left ventricular (LV) hypertrophy (LVH) is associated with LV diastolic dysfunction (LVDD) development and is used as an early marker of CVD in pediatric CKD. This study aimed to assess the prevalence and risk factors of LVDD and the association between LVH and LVDD in Korean pediatric CKD patients. Methods Data were collected using the baseline data of the Korean cohort study for outcome in patients with pediatric chronic kidney disease, a nationwide, 10-year, prospective, observational cohort study of pediatric CKD. A total of 244 patients were included in the final analysis. Two-dimensional echocardiography and tissue Doppler images were used to evaluate LVH and LVDD. LVH was defined as an LV mass index (LVMI) ≥38 g/m2.7 and LV-wall thickness z-score > 1.64. LVDD was defined as a mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E’) > 14. Univariate and multivariate logistic regression analyses were performed to evaluate risk factors of LVDD. Results In this study, the male-to-female ratio was 2.2 (168:76) and median age was 11.2 years. The average estimated glomerular filtration rate was 57.4 ml/min/1.73 m2, and no patients received renal replacement therapy. The mean value of LVMI and E/E’ was 37.0 g/m2.7 and 7.4, respectively. The prevalence of LVH was 40.1 and 17.4% by LVMI ≥38 g/m2.7 and LV-wall thickness z-score, respectively. The prevalence of LVDD was 4.5%, and patients with LVH showed greater risk of LVDD (odds ratio 7.3, p = 0.012). In the univariate analysis, young age, low hemoglobin level, higher LVMI, and higher LV-wall thickness z-score were associated with LVDD. In the multivariate analysis, young age, low hemoglobin level, and higher LV-wall thickness z-score were independently associated with LVDD. Conclusion This study shows that LVH patients have a greater risk of LVDD and that anemia is the only modifiable risk factor for LVDD in Korean pediatric CKD patients.

show abstract

“…1,4,5 Pembesaran ventrikel kiri (LVH), disfungsi sistolik dan diastolik merupakan kelainan kardiovaskular yang paling sering pada PGTA. 6 Melakukan identifikasi, modifikasi, dan mengurangi faktor risiko PGK adalah strategi terbaik untuk mencegah penyakit kardio vasku lar dini. 6,7,8 Penyakit kardiovaskular dini dapat dideteksi pada awal PGK melalui ekokardiografi.…”

unclassified

“…6 Melakukan identifikasi, modifikasi, dan mengurangi faktor risiko PGK adalah strategi terbaik untuk mencegah penyakit kardio vasku lar dini. 6,7,8 Penyakit kardiovaskular dini dapat dideteksi pada awal PGK melalui ekokardiografi. Ekokardiografi digunakan untuk mengukur abnormalitas morfologi, misalnya massa ventrikel kiri (LVM) dan mengetahui fungsi jantung.…”

unclassified

Kelainan Kardiovaskular pada Anak dengan Berbagai Stadium Penyakit Ginjal Kronik

Pabuti¹,

Sekarwana²,

Trihono³

2017

View full text Add to dashboard Cite

Latar belakang. Penyakit kardiovaskular (PKV) merupakan penyebab morbiditas dan mortalitas tersering pada penyakit ginjal kronik (PGK) anak. Hipertrofi ventrikel kiri (LVH) dan disfungsi diastolik paling awal terlihat. Tujuan. Mengetahui proporsi PKV pada PGK stadium 1, hubungan stadium PGK dengan LVH, dan disfungsi jantung. ). Uji stastistik bermakna bila p<0,05. Hasil. Rerata umur subjek 9,1(3,8) tahun. LVH pada 1 dari 3 subjek PGK stadium 1 dan 61,5% pada PGK seluruh stadium, terbanyak stadium 5. Tidak terdapat hubungan bermakna stadium PGK dengan LVH (p=0,055), disfungsi diastolik (p=0,937) dan disfungsi sistolik (p=0,929). Kesimpulan. Pada PGK stadium 1 ditemukan LVH dan disfungsi diastolik. Tidak terdapat hubungan antara stadium PGK dengan LVH dan disfungsi jantung. Sari Pediatri 2016;18(3):220-5Kata kunci: PGK anak, kelainan kardiovaskular Cardiovascular Disorders in Children with Various Stages of Chronic Kidney DiseaseAumas Pabuti,* Nanan Sekarwana,* Partini P. Trihono** Background. Cardiovascular disorders (CVD) are common cause of morbidity and mortality in chronic kidney disease (CKD)'s children. Left ventricle hypertrophy (LVH) and diastolic dysfunction are early sign. Objectives. To study are knowing CVD in CKD stage I, association stages of CVD with LVH, and cardiac dysfunction. Methods. Cross sectional study 26 children with CKD in M Djamil Hospital/ Hasan Sadikin Hospital. Electrocardiography, chest X-ray, echocardiography was measured. LVH if left ventriculer mass index (LVMI) is >95th percentile (38 g/h

show abstract

Assessment of left ventricular function by tissue Doppler echocardiography in pediatric chronic kidney disease

Cited by 15 publications

References 35 publications

Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Left-ventricular diastolic dysfunction in Korean children with chronic kidney disease: data from the KNOW-Ped CKD study

Kelainan Kardiovaskular pada Anak dengan Berbagai Stadium Penyakit Ginjal Kronik

Contact Info

Product

Resources

About