Background: Stroke is a devastating disease that has a high mortality, morbidity, disability, and healthcare cost impact in the United States. Stroke is one of the most serious brain disorders that can result in death or chronic neurological impairment. Objective: this study aimed to determine the effectiveness of interventional program on nurses' knowledge concerning nursing management for Patients with Stroke. Methodology: Quasi–experimental study design was used with the application of pre and posttest approach for both studied and controlled groups at Al-Sadder Medical City, the study has been carried out during the period 1st September 2021 to 1st May 2022. A non-probability (purposive) sample of (60) nurses was split into two groups: (30) nurses were exposed to the nursing interventional program as the study group, and (30) nurses were not exposed to the program. Results: The majority of nurses in both groups are between the ages of (25 - 29), with a significant proportion of female participants (53.3 percent) in both the study and control groups. Overall assessment of study group knowledge regarding management of patients with stroke at the Pre-test was moderate with (0.52) mean of score and Post-test was good with (0.92) mean of score.