Background: Cancer is the serious diseases that's second leading cause of death globally, the increased cancer incident cases, growing aging population, and decreasing number of caregivers have made palliative care more imperative in Egypt. palliative care plays an integral role in these patients' journey of care. Palliative care provides by multidisciplinary to develop a plan of care that focuses on each patient's and family's concerns, values and goals. Aim of the study: Is to assess Nurses' performance regarding palliative care among patients with cancer Research design: A descriptive exploratory design was used to achieve aim of the study. Subject: A convenient sample of 35 nurses working at radiation oncology & nuclear center Setting: The study was conducted in radiation oncology &Nuclear medicine center affiliated to Ain Shams University hospitals Cairo/Egypt. Tools of data collection: Three tools utilized for data collection(1) Self-administered questionnaire to assess nurses' knowledge regarding palliative care among patients with cancer (2) An observational checklist to assess nurses' practice during implementation of palliative care among patients with cancer (3) Nurses attitude Likert Scale to measure nurses' Attitude regarding palliative care Results: Revealed that 74.3% of the studied nurses had unsatisfactory level of knowledge, 94 % of the studied nurses had unsatisfactory level of practices, and 62.9 % of the studied nurses had negative attitude regarding palliative care among patients with cancer. Conclusion: There was unsatisfactory level of knowledge practice and attitude regarding palliative care among studied nurses. Recommendation: Establish periodical in-service training program to improve nurses' performance regarding palliative care, encourage multidisciplinary researches in the same study in order to cover large group of nurses.