Assessment of phytochemical diversity in essential oil composition of eighteen <i>Piper nigrum</i> (L.) accessions from southern India

Ashokkumar, Kaliyaperumal; Vellaikumar, S.; Murugan, M.; Dhanya, M. K.; Karthikeyan, Adhimoolam; Akilan, M.; Ariharasutharsan, G.; Mathews, Nimisha; Aiswarya, S.

doi:10.1080/10412905.2021.1975578

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…No século XV, durante a era das Grandes Navegações, o comércio dessa especiaria foi um fator-chave na expansão do império português e nas relações comerciais internacionais (ASHOKKUMAR, et al 2021;BALIGA, et al 2010).…”

Section: Pimenta-do-reino (Piper Nigrum)unclassified

O Pentáculo Do Bem Estar Como Instrumento De Avaliação Do Modo De Vida Na Atenção Primária a Saúde

Lima,

Aleixo,

Dias

et al. 2024

Ciências Da Saúde: Bem-Estar E Qualidade De Vida 4

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Section: Pimenta-do-reino (Piper Nigrum)unclassified

O Pentáculo Do Bem Estar Como Instrumento De Avaliação Do Modo De Vida Na Atenção Primária a Saúde

Lima,

Aleixo,

Dias

et al. 2024

Ciências Da Saúde: Bem-Estar E Qualidade De Vida 4

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“…Ocimum gratissimum L. belonging to the family Lamiaceae is popularly known as basil and is a shrub found in tropical and subtropical regions of Asia, Africa, and South America (Padalia et al, 2013). It is used as a condiment in cooking and as a sedative and anxiolytic, and in traditional medicines for headache and abdominal pain, cough, cold, and bronchitis (Silva et al, 2015a;Ashokkumar et al, 2020). Its essential oil has been used as an anesthetic (Silva et al, 2012;Silva et al, 2015a), antinociceptive (Rabelo et al, 2003;Sahouo et al, 2003;Paula-Freire et al, 2013), anti-inflammatory (Sahouo et al, 2003), antioxidant (Pereira and Maia, 2007;Vasconcelos et al, 2021), insecticide (Nguemtchouin et al, 2013), and antimicrobial against bacteria and fungi (Vasconcelos et al, 2021;Franco et al, 2007;Matasyoh et al, 2007;Adjou et al, 2013;Dambolena et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The essential oil of O. gratissimum (EOGT) is composed of eugenol as a major constituent (Ashokkumar et al, 2020;Vasconcelos et al, 2021;Matasyoh et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Eucalyptol (1.8-cineol), methyl eugenol, germacrene D, β-ocimene, and caryophyllene, among others, have been described in the literature (Ashokkumar et al, 2020;Vasconcelos et al, 2021;Matasyoh et al, 2007). The antibacterial effect of EOGT has been attributed to eugenol, which can inhibit the growth of Gram-negative and Gram-positive bacteria (Catherine et al, 2012;Marchese et al, 2017;Ulanowska and Olas, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa

Leonardo¹,

Flávia²,

Celia³

et al. 2023

J. Med. Plants Res.

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Ocimum gratissimum essential oil (EOGT) has been evaluated for its antibacterial efficacy, and its combinational therapy with antibiotics may enhance the therapeutic efficiency against infectioncausing bacteria. Herein, we evaluated the chemical composition of EOGT and its antibiotic efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS and GC-FID analyzed EOGT. The antibiotic efficacy was determined by the agar diffusion method, microdilution, minimum inhibitory concentration (MIC), and fractional inhibitory concentration index (FICI). Eugenol (74.2%) was the main component of OGT. Using the agar diffusion method, the action of rifampicin, ciprofloxacin, and tetracycline was evaluated against S. aureus, while the action of cefepime and ciprofloxacin was evaluated against P. aeruginosa. FICI showed a reduced MIC of ciprofloxacin and tetracycline associated with EOGT. In the presence of EOGT, MIC of ciprofloxacin reduced from 0.6 to 0.0006 μg/mL and of tetracycline decreased from 0.028 to 0.0018 μg/mL against S. aureus and from 4 to 0.12 μg/mL against P. aeruginosa. EOGT enhanced the antibacterial efficacy of the antibiotics suggesting a synergistic effect, thereby enhancing the efficacy in treating infection against S. aureus and P. aeruginosa.

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“…Molecules from natural sources such as plants and marine sources are reported to have antioxidant properties against the ROS inside the body by scavenging it (Sethuraman et al, 2017;Purushothaman et al, 2020). Many plants and their phytoconstituents were reported to have strong medicinal properties and pharmacological activities at molecular target levels and resulted in successful manifestations Saranya et al, 2017;Purushothaman et al, 2018;Rathnasamy et al, 2018;Balakrishnan et al, 2018;Ashokkumar et al, 2020;Ashokkumar et al, 2021aAshokkumar et al, & 2021b.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anticancer activities of Solanum nigrum Linn leaves

Bhuvaneshwari,

Ambiga

2022

J. Current Opinion Crop Sci.,

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Solanum nigrum Linn, belonging to the family Solanaceae, is a flowering species native to Australia, South Africa, and Asia. In the present study, the dried S. nigrum leaves were extracted with benzene, diethyl ether, and ethanol by Soxhlet’s extraction and screened qualitatively and quantitatively to determine their total phytoconstituent content and their potential antioxidant evaluation, followed by the GCMS analysis to predict the hit compounds. The highest amounts of phenols (120.50 mg), alkaloids (90.50 mg), and flavonoids (108.75 mg) were present in the diethyl ether extract of the Solanum nigrum leaves. In contrast, saponins (42.50g) are abundant in ethanol extract. The GCMS analysis of diethyl ether extract reported the top compounds with area %, height %, and specific retention times. The major compounds in the GCMS analysis are isopropyl myristate, octadecanedioic acid, and hexadecanedioic acid. Antioxidant assays such as the DPPH assay and reducing power assay revealed that the diethyl ether extract has more antioxidant activity than the standard itself. The two compounds from the GCMS study were then docked against an oncogene BRAF V600E and a mutated tumour suppressor gene p53 Y220C mutant. The results showed that the interaction was good and had higher negative binding energies. We report that S. nigrum leaves have potent antioxidant and anticancer properties.

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Assessment of phytochemical diversity in essential oil composition of eighteen Piper nigrum (L.) accessions from southern India

Cited by 10 publications

References 24 publications

O Pentáculo Do Bem Estar Como Instrumento De Avaliação Do Modo De Vida Na Atenção Primária a Saúde

O Pentáculo Do Bem Estar Como Instrumento De Avaliação Do Modo De Vida Na Atenção Primária a Saúde

Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa

Antioxidant and anticancer activities of Solanum nigrum Linn leaves

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