This study on the evaluation of perception towards capacity building programs and workforce skills in HIV/AIDS supply chain management in Nigeria comprised of research objectives and questions. A structured self-completion pre-tested questionnaire (422) was administered to respondents, 396 were completed and returned, with a response rate of (93. 8%). The respondents (mostly managers, supervisors, specialists, advisors, and officers) were drawn from all levels of the HIV/AIDS supply chain sector and work, the majority from national and state levels, with significant experience and workable knowledge of supply chain management. The study revealed that perception towards capacity-building programs and workforce skills in supply chain management reflects reality and entails a good understanding of the HIV/AIDS supply chain management system, mean ± standard deviation score (3.695 ± 0.889 and 3.455±0.643) on a Likert scale of 1-5 (5-point scale) respectively. Reliability analysis was carried out, and Cronbach’s alpha (α) showed the questionnaire reached acceptable reliability, α = 0.886 (perception towards capacity building programs), and less reliable, α = 0.071 (perception towards workforce skills) in HIV/AIDS supply chain management. Inferential analysis revealed that socio-demographic characteristics such as age, years of experience, and job title/rank influence the perception of workforce skills in supply chain management (P<0.05). Federal and State Ministries of Health should ensure proper and effective supervision to prevent the workforce from having a wrong understanding of its capacity-building programs and workforce skills to avoid its harmful effect.