Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model

Yuksel, Aykut; Erdur, Bülent; Kortunay, Selim; Ergin, Ahmet

doi:10.1016/j.etap.2012.11.001

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…In animal models of cocaine toxicity, sedation with a benzodiazepine increases the mean lethal and convulsive doses of cocaine (Guinn et al, 1980) and improves survival (Guinn et al, 1980;Catravas and Waters, 1981;Yuksel et al, 2013). Through their action on the g-aminobutyric acid receptors in the amygdala and reticular activating system, benzodiazepines function as anxiolytics, sedatives, and antiepileptics.…”

Section: Benzodiazepinesmentioning

confidence: 99%

Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

Connors

Hoffman

2013

J Pharmacol Exp Ther

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Section: Benzodiazepinesmentioning

confidence: 99%

Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

Connors

Hoffman

2013

J Pharmacol Exp Ther

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“…6,19 Ziprasidone, an atypical antipsychotic agent, has been used as a pre-treatment in several studies evaluating cocaine-induced seizures and death. 16–18 A review of the published literature did not identify any cocaine toxicity studies that investigated the new generation antipsychotic agents except ziprasidone; and none appear to have investigated quetiapine and aripiprazole in cocaine toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…All groups were administered 105 mg/kg cocaine hydrochloride (HCl) via an intraperitoneal injection (dose was 70% of the lethal dose) 15 min after the pre-treatment drug administration. 16,17 Cocaine HCl was obtained from Lipomed Laboratories (Arlesheim, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study

et al. 2019

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Objective To assess the effectiveness of pre-treatment with aripiprazole and quetiapine to prevent acute cocaine toxicity in a mouse model of cocaine toxicity. Methods This experimental study included three groups ( n = 25 per group) of mice that were intraperitoneally injected with normal saline solution, 10 mg/kg quetiapine or 10 mg/kg aripiprazole 15 min before 105 mg/kg cocaine hydrochloride. When the cocaine administration was completed, researchers blinded to the study groups observed the mice in terms of seizures and death for a further 30 min. Results In the cocaine + quetiapine group, the mean ± SE time to the first seizure was 10.80 ± 2.27 min and seizure activity was detected in 18 mice (72%) by the end of the 30 min. In the cocaine + aripiprazole group, the mean ± SE time to the first seizure was 18.10 ± 1.94 min and seizure activity was detected in 15 mice (60%) by the end of the 30 min. When compared with the control group, there was a significant difference between the cocaine + quetiapine and cocaine + aripiprazole groups in terms of seizure activity. Survival time was increased in the cocaine + aripiprazole group compared with the control and cocaine + quetiapine groups. Conclusion Quetiapine and aripiprazole pre-treatment reduced seizure activity and delayed the onset of seizures compared with the control group.

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“…Previously we reported the effects of pretreatment with etomidate, ketamine, phenytoin and phenytoin/midazolam on acute, lethal cocaine toxicity ( 21 ). Also recently we determined the effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on the same experimental model ( 22 ). The objective of this study was to determine whether pre-treatment with dexmedetomidine, moxonidine and alpha-methyldopa could attenuate cocaine toxicity.…”

Section: Objectivesmentioning

confidence: 99%

A Comparison of Dexmedetomidine, Moxonidine and Alpha-Methyldopa Effects on Acute, Lethal Cocaine Toxicity

Seyit¹,

Erdur²,

Kortunay³

et al. 2015

Iran Red Crescent Med J

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Background:The treatment of cocaine toxicity is an important subject for emergency physicians. We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicity in mice.Objectives:The aim of this study was to evaluate the effects of dexmedetomidine, moxonidine and alpha-methyldopa in a mouse model of acute cocaine toxicity.Materials and Methods:We performed an experiment consisting of four groups (n = 25 each). The first group received normal saline solution, the second group received 40 µg/kg of dexmedetomidine, the third group received 0.1 mg/kg of moxonidine and the fourth group received 200 mg/kg of alpha-methyldopa, all of which were intraperitoneally administered 10 minutes before cocaine hydrochloride (105 mg/kg). All animals were observed for seizures (popcorn jumping, tonic-clonic activity, or a loss of the righting reflex) and lethality over the 30 minutes following cocaine treatment.Results:The ratio of animals with convulsions was lower in all treated groups when compared to the control (P < 0.001). Furthermore, 68% (n = 17) of animals in the dexmedetomidine group, 84% (n = 21) of the alpha-methyldopa group, 92% (n = 23) of the moxonidine group and 100% (n = 25) of the control group showed evidence of seizure activity (P = 0.009). Cocaine-induced lethality was observed in 12% (n = 3) of the dexmedetomidine group, 48% (n = 12) of the alpha-methyldopa group, 52% (n = 13) of the moxonidine group, and 72% (n = 18) of the control group (P < 0.001). All treatments prolonged the time to seizure, which was longest in the dexmedetomidine group (P > 0.05). In addition, the time to lethality was also longer in the same group (P < 0.001).Conclusions:The present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. Premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. In addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality.

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Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model

Cited by 6 publications

References 25 publications

Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study

A Comparison of Dexmedetomidine, Moxonidine and Alpha-Methyldopa Effects on Acute, Lethal Cocaine Toxicity

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