Assessment of sample pooling for SARS-CoV-2 molecular testing for screening of asymptomatic persons in Tunisia

Abid, Salma; Ferjani, Sana; Moussi, Awatef El; Ferjani, Asma; Nasr, Mejda; Landolsi, Ichrak; Saidi, Karima; Gharbi, Hanène; Letaief, Hajer; Hechaichi, Aicha; Safer, Mouna; Alaya, Nissaf Bouafif ep Ben; Boubaker, Ilhem Boutiba-Ben

doi:10.1016/j.diagmicrobio.2020.115125

Cited by 17 publications

(16 citation statements)

References 6 publications

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“…Pooling of samples may gener ally induce practical pretesting burden and may lower traceability, and thus sample pooling should perhaps be restricted to times of reagent shortage. The jury is still out on whether pooling is diagnostically robust and cost effective, with conflicting reports having been published [50][51][52] . In addition, the current consensus is that individual laboratories should perform validation studies before embarking on large scale pooling strategies 52 .…”

Section: Considerations For the Development Production And Distributmentioning

confidence: 99%

Considerations for diagnostic COVID-19 tests

et al. 2020

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During the early phase of the coronavirus disease 2019 (COVID-19) pandemic, design, development, validation, verification and implementation of diagnostic tests were actively addressed by a large number of diagnostic test manufacturers. Hundreds of molecular tests and immunoassays were rapidly developed, albeit many still await clinical validation and formal approval. In this Review, we summarize the crucial role of diagnostic tests during the first global wave of COVID-19. We explore the technical and implementation problems encountered during this early phase in the pandemic, and try to define future directions for the progressive and better use of (syndromic) diagnostics during a possible resurgence of COVID-19 in future global waves or regional outbreaks. Continuous global improvement in diagnostic test preparedness is essential for more rapid detection of patients, possibly at the point of care, and for optimized prevention and treatment, in both industrialized countries and low-resource settings.

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Section: Considerations For the Development Production And Distributmentioning

confidence: 99%

Considerations for diagnostic COVID-19 tests

et al. 2020

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“…By this, apart from conserving cost of extraction and PCR reagents, a judicious cap into cost of VTM can also be achieved. Various studies had explored the feasibility, practicality and optimal size for pool testing recently [ [14] , [15] , [16] , [17] , [18] , [19] ].Yelin et al. showed the detection of SARS-CoV-2 in pool of 32 samples and potentiallyin 64 samples [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Pooled nasopharyngeal swab collection in a single vial for the diagnosis of SARS CoV-2 infection: An effective cost saving method

Agarwal¹,

Gupta²,

Dubey³

et al. 2021

Indian Journal of Medical Microbiology

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“…Some strategies could be considered to reduce the testing costs like pooling samples for testing (Abid et al, 2020) or concentrating the tests in neighborhood where sewege systems were tested positive (Foladori et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Modelling the Test, Trace and Quarantine Strategy to Control the COVID-19 Epidemic in the State of São Paulo, Brazil

Amaku

Covas

Coutinho

et al. 2020

Preprint

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Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of society. In this paper we modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of São Paulo, Brasil. The State of São Paulo failed to adopt an effective social distancing strategy, reaching at most 59% in late March and started to relax the measures in late June, dropping to 41% in 08 August. Therefore, São Paulo relies heavily on a massive testing strategy in the attempt to control the epidemic.Two alternative strategies combined with economic evaluations were simulated. One strategy included indiscriminately testing the entire population of the State, reaching more than 40 million people at a maximum cost of 2.25 billion USD, that would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts – this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.The conclusion is that if the State of São Paulo had decided to adopt the simulated strategy on April the 1st, it would have been possible to reduce the total number of cases by 90% at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.

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Assessment of sample pooling for SARS-CoV-2 molecular testing for screening of asymptomatic persons in Tunisia

Cited by 17 publications

References 6 publications

Considerations for diagnostic COVID-19 tests

Considerations for diagnostic COVID-19 tests

Pooled nasopharyngeal swab collection in a single vial for the diagnosis of SARS CoV-2 infection: An effective cost saving method

Modelling the Test, Trace and Quarantine Strategy to Control the COVID-19 Epidemic in the State of São Paulo, Brazil

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