Assessment of selected immunological parameters in dairy cows with naturally occurring mycotoxicosis before and after the application of a mycotoxin deactivator

Brodzki, Piotr; Marczuk, Jan; Lisiecka, Urszula; Krakowski, Leszek; Szczubiał, Marek; Dąbrowski, Roman; Bochniarz, Mariola; Kulpa, Katarzyna; Brodzki, Nikodem; Wolniaczyk, Karolina

doi:10.2478/jvetres-2023-0002

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Також повідомляється, що при годівлі корів кормами, які містять велику кількість мікотоксинів, загальний імунітет тварин знижується, що провокує розвиток запальних процесів у піхві, матці та яєчниках (Yousef et al, 2017;Brodzki et al, 2023).…”

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The role of obstetrical diseases in the development of subclinical metritis

Chekan

2023

SMLNUVMB

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The results of the dependence of obstetric diseases of cows in the occurrence of subclinical abortions against the background of the development of metritis under the influence of mycotoxins are given. Subclinical metritis is a fairly common phenomenon in cows, which causes significant economic losses. At the same time, the number of subclinical metritis in cows correlates with the number of obstetric pathology. Due to the negative impact of mycotoxins, in particular zearalenone, the balance of sex hormones is disturbed, which creates conditions for the development of saprophytic microflora in the organs of the reproductive system of cows. At the same time, deoxynivalenol helps to reduce the resistance of the cow's body in general and mucous membranes, in particular, which contributes to the development of inflammatory processes in the uterus. These processes are often subclinical. The aim of the work was to find out the role of obstetric diseases in the development of subclinical metritis and to develop clinical and prognostic tests for the occurrence of metritis and the basis for the analysis of obstetric pathology. The spread of obstetric pathology was established depending on the way cows are kept. Thus, in farms where cows were kept on tethers, the number of obstetric pathologies was 15.5 times higher. However, the number of inflammatory processes in the organs of the reproductive system in such farms was lower by 12 %. A decrease in the level of T- and B-lymphocytes in the blood and suppression of their functional activity was established, which is manifested by a decrease in the level of immunoglobulin G and has a significant effect on the increase in the frequency of subclinical abortions. The dependence of the reproductive capacity of cows on the frequency of subclinical and chronic inflammatory processes of the reproductive organs, which occur against the background of mycotoxicosis, was established. The influence of mycotoxins on the functioning of the ovaries and uterus was studied, and an increase in the number of such cases was established in farms with tethered cows. The correlation between the contamination of cow feed and the reduction of fertilization in cows was found. An increase in the number of subclinical abortions under the influence of zearalenone, which is found in large quantities in feed, has been established. The dependence of ovarian disorders on increasing productivity in cows was investigated.

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Section: вступunclassified

The role of obstetrical diseases in the development of subclinical metritis

Chekan

2023

SMLNUVMB

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“…В той же час велика кількість авторів вказують на патологічні стани, що спричинюють порушення утворення гормонів, зокрема при хронічному отруєнні корів зеараленоном (Becker-Algeri et al, 2016;Kemboi et al, 2020;Vandicke et al, 2021). Також є повідомлення про велику кількість засобів для профілактики та лікування мікотоксикозів корів (Brodzki et al, 2023).…”

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The Effect of Aromatases Inhibitor-Based Products on Cow Reproductive Ability

Chekan

2023

SCIVP

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Mycotoxin zearalenone is a phytoestrogenic substance that can disrupt the functioning of the organs of the reproductive system of cows. At the same time, a hyperestrogenic state occurs, which leads to overeating, multiple unsuccessful inseminations and infertility of cows. The purpose of the research is to investigate the effect of a single application of drugs based on aromatase inhibitors on the main biochemical and hormonal parameters of the blood of cows, as well as to establish their effectiveness during spontaneous expression of desire and when applying synchronization schemes. The effect of a single dose of aromatase inhibitors on the dynamics of sex hormones in cows, which directly affect the formation of the dominant follicle and its ovulation, was investigated. At the same time, a 1.56-fold decrease in estradiol, a 1.67-fold increase in progesterone, a 1.29-fold increase in luteinizing hormone, and a 1.76-fold increase in follicle-stimulating hormone were found. At the same time, the maturation of the dominant follicle and its ovulation at a size of 22 to 24 mm have been established. A change in the biochemical parameters of the blood serum of cows after the use of products based on an aromatase inhibitor was revealed. A tendency was established to restore the level of calcium to 2.01±0.27 mmol/l, phosphorus – 1.1±0.41 mmol/l, magnesium – 0.87±0.11 mmol/l, selenium –1.0± 0.1 mmol/l. At the same time, the level of creatinine decreased by 1.2 times compared to sick animals, the indicators of liver transferases also tended to decrease. A significant decrease in the blood urea index by 1.69 times was established, which indicates the restoration of protein and lipid metabolism. The indicators of fertilization of cows with spontaneous manifestation of sexual desire when using agents based on aromatase inhibitors were studied. At the same time, the fertility rate ranged from 69.39% in cows older than 5 years to 80.39% in cows after the 1st calving. A positive effect of aromatase inhibitors, introduced before the use of estrus synchronization schemes in cows, was established on the development of the dominant follicle, luteogenesis and the appearance of a new wave of follicle development. Fertilization averaged from 68.1% to 76.42%.

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Changes in Protein Metabolism Indicators in Dairy Cows with Naturally Occurring Mycotoxicosis before and after Administration of a Mycotoxin Deactivator

Marczuk

Brodzki

et al. 2023

Agriculture

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The aim of the study was to evaluate selected indicators of protein metabolism in cows fed with fodder contaminated with mycotoxins after application of a mycotoxin deactivator product (MDP). Experimental group (Exp.)—10 cows, fed total mixed ration (TMR) containing: 0.769 mg/kg-deoxynivalenol and 0.032 mg/kg-zearalenone TMR DM. Control group (Con.)—10 cows fed TMR without mycotoxins. In the exp. cows, the mycotoxin deactivator product (MDP) Mycofix Plus was used in the form of an additive to TMR in the amount of 10 g/head/day for 90 days. Blood was taken in Exp. group three times, before MDP administration, and on days 30 and 90 of its use. In the con. group, blood was collected once. All cows were assessed for free amino acids, total protein, albumin, globulin, and urea. Cows with mycotoxicosis (before MDP administration) showed low total protein, albumin, total-essential (TEAA) and total-non-essential amino acids (TNEAA) compared to after MDP administration (p < 0.01). Compared to the control group, TNEAA values were lower and TEAA higher on all study dates (p < 0.001). The results of our research showed the negative impact of mycotoxins on the parameters of protein metabolism in cows, and the use of MDP improved the processes of protein metabolism and improved the overall health of cows.

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Assessment of selected immunological parameters in dairy cows with naturally occurring mycotoxicosis before and after the application of a mycotoxin deactivator

Cited by 3 publications

References 48 publications

The role of obstetrical diseases in the development of subclinical metritis

The role of obstetrical diseases in the development of subclinical metritis

The Effect of Aromatases Inhibitor-Based Products on Cow Reproductive Ability

Changes in Protein Metabolism Indicators in Dairy Cows with Naturally Occurring Mycotoxicosis before and after Administration of a Mycotoxin Deactivator

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