Assessment of the Datex Relaxograph During Anaesthesia and Atracurium-Induced Neuromuscular Blockade

Carter, J.A.; Arnold, R. W.; Yate, P.M.; Flynn, P. J.

doi:10.1093/bja/58.12.1447

Cited by 42 publications

(13 citation statements)

References 5 publications

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“…Although the results of measurements from EMG and MMG correlate well (32), these cannot be used interchangeably (33, 34). Evoked EMG records the compound muscle action potential using recording electrodes after stimulation of the corresponding nerve.…”

Section: Equipmentmentioning

confidence: 99%

Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Fuchs‐Buder

Claudius

Skovgaard

et al. 2007

Acta Anaesthesiol Scand

583

574

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The set of guidelines for good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents, which was developed following an international consensus conference in Copenhagen, has been revised and updated following the second consensus conference in Stockholm in 2005. It is hoped that these guidelines will continue to help researchers in the field and assist the pharmaceutical industry and equipment manufacturers in enhancing the standards of the studies they sponsor.

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Section: Equipmentmentioning

confidence: 99%

Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Fuchs‐Buder

Claudius

Skovgaard

et al. 2007

Acta Anaesthesiol Scand

583

574

View full text Add to dashboard Cite

show abstract

“…The data generated by the indirectly evoked EMG should be used with some understanding of its limitations as a predictor of mechanical response. Although Carter and colleagues [11] found a good correlation between the two methods of measurement for both twitch height and trainof-four ratio (correlation coefficients 0.93 and 0.97, respectively), Kopman [12] found that the simultaneously evoked (hypothenar) EMG and MMG did not give identical information. The regression line for the Tl :Tc (twitch depression/ control twitch) ratio was parallel to the line of identity, but showed an absolute offset of 15%.…”

Section: Discussionmentioning

confidence: 97%

Effect of Suxamethonium Given During Recovery From Atracurium

SCOTT¹,

NORMAN²

1989

British Journal of Anaesthesia

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At the end of an abdominal operation, muscle relaxation may be inadequate and a transient increase in block may be needed to facilitate closure. Suxamethonium is the only agent of short duration available currently [1] and has been used in these circumstances. Whilst interactions with long acting competitive agents have been described [2-5], there are no descriptions of its effect on recovery from the block produced by atracurium. This study was designed to assess the effects of increasing doses of suxamethonium on the recovery of block produced by atracurium and on the subsequent interaction with neostigmine. PATIENTS AND METHODS Thirty-eight patients (18-70 yr, 45-110 kg) undergoing elective surgical procedures were studied after they had given informed consent. No patient who had received aminoglycoside antibiotics was studied. The study was approved by the local Ethics Committee. Diazepam 10-20 mg and metoclopramide 10 mg were given by mouth 1 h before anaesthesia was induced with thiopentone 4-6 mg kg" 1 and fentanyl 2-4ugkg~1. Anaesthesia was maintained with 66% nitrous oxide and 0.5% enflurane in oxygen supplemented by additional doses of fentanyl and thiopentone as required. End-tidal carbon dioxide tension was maintained at 4-5 kPa. The integrated, rectified and gated electromyographic response of the hypothenar muscles was recorded in response to supramaximal train-• of-four stimuli delivered to the ulnar nerve at 20-s intervals using a Datex Relaxograph. Control

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“…After induction of anaesthesia, 30 min was allowed for stabilization, during which time Ringer's lactate 500-750 ml was administered to ensure optimal peripheral circulation. Recovery from suxamethonium block was assessed with a neuromuscular relaxation monitor (Relaxograph NMT-100 rev.01, software 3.0, Datex, Finland) [6]. No other neuromuscular blocking drug was used during the study.…”

Section: Methodsmentioning

confidence: 99%

“…curarization after operation [1,2]. In clinical anaesthesia, the evoked compound action potential (ECAP) response of the hand muscles [3][4][5][6] may be used to monitor neuromuscular block.…”

mentioning

confidence: 99%

Effect of Surface Electrode Positioning on the Compound Action Potential Evoked by Ulnar Nerve Stimulation in Anaesthetized Infants and Children

Kalli¹

1989

British Journal of Anaesthesia

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The effect of surface electrode positioning on the evoked compound action potential (ECAP) was studied during inhalation anaesthesia without neuromuscular blockade. The ECAP of five full-term infants (aged 2-20 weeks) and five children (age 1-10 yr) was recorded with a neuromuscular relaxation monitor (Relaxograph, Datex) after supramaximal ulnar nerve stimulation. The five recording electrode positions compared were: thenar (adductor pollicis) v. second finger (TD2); thenar v. second dorsal metacarpal interspace (TM2); hypothenar v. fifth finger (HD5); hypothenar v. fourth dorsal metacarpal interspace (HM4); thenar v. hypothenar (TH). The ECAP was steady at positions TD2 and HD5, but marked variation and baseline drift was found at TM2, HM4 and TH. The ECAP peak-to-peak amplitudes were twice as great in children compared with infants. The hypothenar ECAP was liable to stimulus artefact interference because of the short onset latency at HD5 (2.2(SD 0.4)ms), whereas the adductor pollicis (3.0(SD 0.5)ms) position (TD2) yielded reliable results.

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Assessment of the Datex Relaxograph During Anaesthesia and Atracurium-Induced Neuromuscular Blockade

Cited by 42 publications

References 5 publications

Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Effect of Suxamethonium Given During Recovery From Atracurium

Effect of Surface Electrode Positioning on the Compound Action Potential Evoked by Ulnar Nerve Stimulation in Anaesthetized Infants and Children

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