Assessment of the degree of adherence of medical laboratories to KDIGO 2012 guideline for evaluation and management of CKD in Czechia and Slovakia

Skalický, T; Friedecký, B; Kratochvíla, Josef; Pelinková, Květa; Budina, Marek

doi:10.11613/bm.2019.030704

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Aging and lifestyle habits have an impact on kidney function. Japan is experiencing an increase in its elderly demographic, and it is projected that the incidence of CKD will rise correspondingly within this aging populace in the imminent future 4 , 5 . The number of end-stage kidney disease (ESKD) patients has also continued to increase in Japan 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes

Nyma,

Kitaoka,

Yano

et al. 2024

Sci Rep

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Understanding the association between compliance to the Chronic Kidney Disease (CKD) guidelines in real-world clinical settings and renal outcomes remains a critical gap in knowledge. A comprehensive analysis was conducted using data from a national, multicenter CKD registry. This study included 4,455 patients with an estimated glomerular filtration rate (eGFR) measurement on the index date and eight additional metrics recorded within six months. These metrics comprised serum electrolyte levels, low-density lipoprotein cholesterol, hemoglobin, and the use of renin-angiotensin system inhibitors. The primary outcome was a composite of renal events, defined by a decline in eGFR to < 15 mL/min/1.73 m2 or a reduction of ≥ 30% in eGFR, confirmed by follow-up tests. Over a median follow-up of 513 days, 838 renal events were observed. High serum potassium levels (> 5.4 mmol/L) were associated with increased event rates compared to lower levels. Similarly, low serum sodium-chloride levels (< 33) correlated with higher event rates. Usage of renin-angiotensin system inhibitors, low serum calcium (< 8.4 mg/dL), and high uric acid levels (> 7.0 mg/dL) were also linked to increased events. Conversely, higher hemoglobin levels (≥ 13 g/dL) were associated with lower event rates. Compliance to guidelines, categorized into quartiles based on the number of met metrics, revealed a significantly reduced risk of events in the highest compliance group (meeting 8 metrics) compared to the lowest (0–5 metrics). Compliance to CKD guidelines in clinical practice is significantly associated with improved renal outcomes, emphasizing the need for guideline-concordant care in the management of CKD.

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Section: Introductionmentioning

confidence: 99%

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes

Nyma,

Kitaoka,

Yano

et al. 2024

Sci Rep

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“…The measurement of plasma drug concentrations that are ordered by different clinical disciplines is centralized in medical laboratories. A questionnaire is an important tool to assess current laboratory practice in some fields of medicine (7). It may be also the first step in the development of guidelines (8).…”

Section: Introductionmentioning

confidence: 99%

Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia

Skalický¹,

Schneiderka²,

Studená

et al. 2020

Biochem. med. (Online)

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Introduction: The aim of the study was to investigate current practice and policies of therapeutic drug monitoring (TDM) service requesting and result reporting in Czechia and Slovakia. Materials and methods: All 149 laboratories that measure plasma drug concentrations were given an online questionnaire during a regular external quality assessment TDM cycle. The questionnaire consisted of 17 questions. The optimal TDM practice was defined as the application of all elements (age, body weight, time of sampling, date of the first administration, time of the last dose administration, the dose, the dosing interval, the route of administration, information on reason of testing, and information on other co–administered drugs) needed for reporting a recommendation for further drug dosing (positive response to question number 16). Results: The response rate was 69%, 103 out of 149 laboratories measuring drug concentrations. Only 12% (12 out of 103 laboratories) of the laboratories implemented all elements needed for optimal TDM practice and reported a recommendation. Both paper and electronic request forms were used by 77 out of 103 (75%) laboratories. A total of 69 out of 103 laboratories (67%) specified the type of sampling tube on their request form. Cystatin C was used for prediction of renal drug elimination by 24% (25 out of 103) of participants. Conclusions: Small number of laboratories implemented all elements needed for optimal TDM practice and report a recommendation on further dosing. Further efforts in education on optimal TDM practice as well as harmonization of service are desirable.

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Evaluating the Associations Between Compliance with CKD Guideline Component Metrics and Renal Outcomes

Nyma,

Kitaoka,

Yano

et al. 2024

Preprint

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Background Understanding the association between compliance to the Chronic Kidney Disease (CKD) guidelines in real-world clinical settings and renal outcomes remains a critical gap in knowledge. Methods A comprehensive analysis was conducted using data from a national, multicenter CKD registry. This study included 4,455 patients with an estimated glomerular filtration rate (eGFR) measurement on the index date and eight additional metrics recorded within six months. These metrics comprised serum electrolyte levels, low-density lipoprotein cholesterol, hemoglobin, and the use of renin-angiotensin system inhibitors. The primary outcome was a composite of renal events, defined by a decline in eGFR to < 15 mL/min/1.73 m² or a reduction of ≥ 30% in eGFR, confirmed by follow-up tests. Results Over a median follow-up of 513 days, 838 renal events were observed. High serum potassium levels (> 5.4 mmol/L) were associated with increased event rates compared to lower levels. Similarly, low serum sodium-chloride levels (< 33) correlated with higher event rates. Usage of renin-angiotensin system inhibitors, low serum calcium (< 8.4 mg/dL), and high uric acid levels (> 7.0 mg/dL) were also linked to increased events. Conversely, higher hemoglobin levels (≥ 13g/dL) were associated with lower event rates. Adherence to guidelines, categorized into quartiles based on the number of met metrics, revealed a significantly reduced risk of events in the highest compliance group (meeting 8 metrics) compared to the lowest (0–5 metrics). Conclusions Compliance to CKD guidelines in clinical practice is significantly associated with improved renal outcomes, emphasizing the need for guideline-concordant care in the management of CKD.

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Assessment of the degree of adherence of medical laboratories to KDIGO 2012 guideline for evaluation and management of CKD in Czechia and Slovakia

Cited by 3 publications

References 18 publications

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes

Survey on request form content and result reporting in therapeutic drug monitoring service among laboratories in Czechia and Slovakia

Evaluating the Associations Between Compliance with CKD Guideline Component Metrics and Renal Outcomes

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