Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia

Abstract

Objective:The neutrophil/lymphocyte ratio (NLR) has been evaluated as a new predictor of cardiovascular risk. Inflammation has been shown to be associated with various arrhythmias including supraventricular tachycardias (SVTs). In this study, we aimed to investigate the relation between NLR and SVT in patients with a documented atrial tachyarrhythmia.Methods:The study used a retrospective cross-sectional design. Patients who had SVT but were otherwise healthy were included. The exclusion criteria included drug use (except antiarrhythmic agents), morbid obesity, acute or chronic infection, inflammatory diseases, systemic diseases, and cancer. Total and differential leukocyte counts and routine biochemical tests were performed before the ablation procedure.Results:The study included 150 patients with SVT and 98 healthy controls. The biochemical and hematological parameters were comparable between the groups, except neutrophil and lymphocyte counts. The neutrophil count was significantly higher (4.7±1.5×103/µL versus 4.1±1.0×103/µL; p<0.001) and lymphocyte count was significantly lower (2.2±0.6×103/µL versus 2.5±0.6×103/µL; p=0.001) in the SVT group than in the control group. As a result, the SVT group had significantly higher NLR values than the control group (2.2±0.9 versus 1.7±0.5; p<0.001). In addition, NLR values were higher in patients in whom tachycardia was induced during an electrophysiological study (EPS) (2.3±0.9 versus 2.0±0.8; p=0.02). The association between NLR and SVT remained significant after multivariate analysis (odds ratio: 1.5, 95% confidence interval: 1.001-2.263, p=0.049).Conclusion:Our study indicated that NLR values were significantly higher in patients with documented SVT than in control subjects. Inducibility of SVT during EPS was associated with higher NLR values.

Neutrophil/Lymphocyte Ratio as a Predictor of In-Hospital Major Adverse Cardiac Events, New-Onset Atrial Fibrillation, and No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction

“…13 Furthermore, in a study conducted by Aydin et al, patients with documented supraventricular tachycardia showed significantly higher N/L ratio values compared with control subjects. 14 The limitations of this study are the relatively small sample size compared with large studies published in the literature, such that larger studies are needed to validate our results, and the lack of multivariate statistical analysis, which might have affected the results.…”

Enhanced monocyte migratory activity in the pathogenesis of structural remodeling in atrial fibrillation

“…indicated an increased proportion of the CD14++CD16+ intermediate monocyte subset in AF subjects compared to that of healthy control subjects [ 27 ], while our flow cytometric analysis showed no difference in the proportions of intermediate monocytes between non-AF and AF participants. This discrepancy in the results between the two studies may arise from inclusion of a control group population; in the Suzuki et al .’s study, healthy individuals without any cardiovascular health problems and who were supposedly low in inflammation served as the control group, whereas in our study, the control group was comprised of PSVT patients who could be predisposed with inflammatory status [ 28 ]. Meanwhile, consistent with our results, Suzuki et al .…”

Progress of Pathogenesis in Pediatric Multifocal Atrial Tachycardia

“…All of these facilitate the formation of arrhythmogenic substrates, which can ultimately result in enhanced automaticity, reentry, and triggered activity ( 62 ). Previous research have reported that inflammation could promote the release of inflammatory cytokines, such as TNF-α, IL-6, and IL-8, which also have been used as an important biomarker of acute infection and played a role in the prediction of AT in partial patients ( 62 , 63 ). Therefore, it is necessary to further explore the role of these biomarkers in MAT and find more suitable biomarkers for predicting MAT.…”