Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma

Abstract

Our data suggest that inherited abnormalities of XPC, XPF, TP53 and GSTP1 pathways of the DNA repair, apoptosis and metabolism of reactive oxygen species are important determinants of CM in individuals from south-eastern Brazil.

A meta‐analysis of XPC Lys939Gln polymorphism and melanoma susceptibility

“…A total of 81 studies were retrieved through database searching. After reading the titles and abstracts, nine potential studies were identified for further investigation . One case–control study was excluded for being not consistent with HWE .…”

“…One case–control study was excluded for being not consistent with HWE . Finally, eight studies were included for data extraction . The studies were published between 2005 and 2013 (Table ).…”

“…It is of interest to evaluate whether the XPC Lys939Gln polymorphism plays an essential role for melanoma risk. Although several previous studies have investigated the association between Lys939Gln polymorphism in XPC gene and risk of melanoma, the results of the studies were not consistent . The exact relationship between the XPC Lys939Gln polymorphism and susceptibility to melanoma is not entirely established.…”

XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma

“…It is already well established that abilities to DNA damage repair are variable in humans and may affect CM susceptibility [13][14][15]. The XPC single nucleotide polymorphism (SNP) with an A>C substitution at nucleotide 2920 (Lys939Gln) was associated with a lower function of the encoded protein of DNA damage repair in peripheral blood lymphocytes challenged by mutagens and gamma radiation [16].…”

Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

“…rs1042522 polymorphism is located in exon 4 of p53 gene, in which an arginine (Arg)gproline (Pro) amino acid substitution is present at amino acid position 72; such polymorphism is commonly named Pro72Arg or codon polymorphism (Ara et al, 1990). Epidemiological studies have indicated that p53 Arg72Pro polymorphism increases the risk of many cancers, such as cutaneous melanoma (Oliveira et al, 2013), bladder cancer (Xu et al, 2012), and nasopharyngeal carcinoma . However, two meta-analyses have failed to identify a significant association between p53 Arg72Pro polymorphism and oral cancer Jiang et al, 2013).…”