Assessment of Thyroid Dysfunction, Dyslipidaemia and Oxidative Stress in Hypertensive End Stage Chronic Renal Disease Patients in a Teaching Hospital in Western U. P.

Abstract

BACKGROUNDCKD is a serious health problem worldwide. In developing nation, CKD has severe implication on health and economic output. The rapid increase of common risk factors such as hypertension (HTN), obesity and type 2 diabetes will result in greater burden on developing countries. There are many complications associated with CKD including thyroid dysfunction, dyslipidaemia, hypertension and cardiovascular disease (CVD). It is generally seen that patients suffering from CKD are at high risk of cardiovascular disease. METHODS This is a cross sectional comparative study conducted in Saraswathi MedicalCollege and Hospital, Hapur (Uttar Pradesh). Thyroid status, lipid profile, serum urea, serum creatinine, serum uric acid, serum electrolyte, catalase, malondialdehyde (MDA) and superoxide dismutase (SOD) were assayed in 160 subjects of which 80 patients of CKD were having hypertension and 80 healthy controls. RESULTSIn our study, we found statistically significant increase in the level of (p<0.001) malondialdehyde (MDA) and significantly decreased level (p<0.001) of catalase and superoxide dismutase (SOD). Significantly increased level (p<0.001) of TSH was found in CKD patients with associated hypertension. We also found deranged lipid profile and renal functions in CKD patients with associated hypertension as compared to controls. CONCLUSIONSDyslipidaemia and thyroid dysfunction are very common in CKD patients. Our study revealed that there was significant association between thyroid dysfunction and CKD progression and dyslipidaemia. The antioxidant status is assessed through changes in antioxidant enzymatic activity in patients of CKD with associated hypertension and data provides evidence of blood pressure modulation by measurable oxidative stress-related parameters.