Assessment of thyroid function in pesticide formulators

Zaidi, S. S. A.; Bhatnagar, V. N.; Gandhi, Sumitra J.; Shah, Mehul; Kulkarni, P. K.; Saiyed, H. N.

doi:10.1191/096032700677928536

Cited by 43 publications

(19 citation statements)

References 22 publications

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“…T 3 level was normal in all spray painters and ranged from 0.65-1.30 ng/ml (normal range 0.80-2.0 ng/ml). An elevation in the level of thyroid hormones (TSH) have also been reported by us earlier in pesticides formulators 12) and welders 13) and these studies substantiate our present findings on the pattern of thyroid levels in spray painters.…”

Section: Resultssupporting

confidence: 81%

Neurobehavioral Effects and Hormones Profile among Spray Painters

et al. 2006

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A cross-sectional study was conducted in 25 spray painters and 35 control subjects to evaluate neurobehavioral function, and thyroid and reproductive hormones profile. This study indicated higher prevalence of psychological and neurological symptoms, and clinical findings among spray painters when compared with controls. Levels of TSH were significantly (p<0.01) elevated in spray painters over the control group (3.04 ± 1.53 vs 1.88 ± 1.07 µ µ µ µ µIU/ml, mean ± SD), respectively.Two of the 25 spray painters acquired sub-clinical hypothyroidism, and one subject was detected with overt hypothyroidism. T 4 levels were significantly (p<0.05) suppressed in spray painters while T 3 was not changed significantly in both the groups. Reproductive hormones (LH, FSH, and testosterone) showed no significant changes in control and spray-painting group. However, two spray painters had abnormally high level of LH (26.43 and 12.22 IU/l; normal range 0.5-10 IU/l). These subjects were also found to have abnormally higher level of FSH (38.63 and 14.11 IU/l; normal range 1.3-11.5 IU/l). An isolated higher level of FSH (39.94 IU/l) was also observed in one spray painter. No abnormality in the level of LH was observed in control group while 3 subjects from this group had abnormally high level of FSH. Testosterone levels were under the normal range (3-12 ng/ ml) in both the groups. This study might suggest that spray painters are at risk of developing neurobehavioral, thyroid and reproductive problems.

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Section: Resultssupporting

confidence: 81%

Neurobehavioral Effects and Hormones Profile among Spray Painters

et al. 2006

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“…Total T 3 was suppressed significantly in formulators while a marginal decrease (7%) was noticed in T 4 level. TSH levels were also elevated by 28% but the rise was statistically insignificant (Zaidi et al, 2000). These formulators had significantly low serum cholinesterase activity and high serum BHC content indicating appreciable exposure to their working environment.…”

Section: Health Hazards Of Occupational Exposurementioning

confidence: 86%

Pesticide exposure—Indian scene

Gupta¹

2004

Toxicology

365

154

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“…Farmers who had aerial application of fungicides to their land showed a significant shift in TSH values; subclinical hypothyroidism was noted in rural applicators (TSH values >4.5 mU/L), but not in urban control subjects. The level of TSH was elevated also in male pesticide formulators exposed to the dust and liquid formulation of endosulfan, quinalphos, chlorpyriphos, monocrotophos, lindane, parathion, phorate, and fenvalerate as compared to a control group, but the increase was statistically insignificant (Zaidi et al, 2000).…”

Section: Mixtures (Pesticides)mentioning

confidence: 90%