Assessment of working-memory deficits in patients with mild cognitive impairment and Alzheimer’s dementia using Wechsler’s Working Memory Index

Kessels, Roy P. C.; Molleman, Pieter W.; Oosterman, Joukje M.

doi:10.1007/bf03325245

Cited by 38 publications

(34 citation statements)

References 19 publications

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“…Parra et al, 2011). In general, more consideration should be given to the assessment of the working memory domain in patients with early-stage Alzheimer's disease, notably amnestic MCI patients, as there is increasing evidence that working memory is already compromised in these patients (Belleville, Chertkow, & Gauthier, 2007;Belleville, Peretz, & Malenfant, 1996;Guild et al, 2014;Kessels, Molleman, & Oosterman, 2011).…”

Section: Discussionmentioning

confidence: 99%

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Geldorp

Heringa

Berg

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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Section: Discussionmentioning

confidence: 99%

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Geldorp

Heringa

Berg

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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“…Although early and significant episodic memory impairment constitutes the clinical core diagnostic criterion of AD (Dubois et al, 2014), there is increasing evidence of early deficits in WM and executive function in patients with MCI and AD (Crawford et al, 2013;Gagnon and Belleville, 2011;Huntley and Howard, 2010;Kessels et al, 2011;Koppel et al, 2014). Moreover, fMRI studies have also suggested a possible subclinical impairment of WM capacity in healthy APOE ε4 carriers (Chen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals

Zhang

et al. 2015

Neuropsychopharmacol

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Alzheimer's disease (AD) is the most common form of dementia and exhibits a considerable level of heritability. The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most important risk locus for AD following apolipoprotein E (APOE). However, how and when the established genetic risk locus BIN1 rs744373 confers risk to late-onset AD has yet to be determined. Here using an imaging genetic strategy in large-sample Chinese subjects, we show that healthy homozygous carriers of the rs744373 risk allele exhibit worse high-load working memory (WM) performance, larger hippocampal volume and lower functional connectivity between the bilateral hippocampus and the right dorsolateral prefrontal cortex (DLPFC), mirroring clinical evidence of disturbed memory and connectivity in patients. Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.

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“…Many studies have reported behavioral deficits in WM in individuals with MCI [9,10,11,12,13,14,15,16,17,18,19]. Specifically, these individuals have been found to have deficits in verbal [10,11,15,17,19], visual [9], spatial [13,14,18], and object-location WM memory [9,16]. Moreover, these WM deficits have been found in different MCI subtypes, including amnestic and nonamnestic MCI [12,19] and single- and multiple-domain MCI [12].…”

Section: Introductionmentioning

confidence: 99%

Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy

Yeung¹,

Sze²,

Woo

et al. 2016

Dement Geriatr Cogn Disord

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Background: Some functional magnetic resonance imaging studies have reported altered activations in the frontal cortex during working memory (WM) performance in individuals with mild cognitive impairment (MCI), but the findings have been mixed. The objective of the present study was to utilize near-infrared spectroscopy (NIRS), an alternative imaging technique, to examine neural processing during WM performance in individuals with MCI. Methods: Twenty-six older adults with MCI (7 males; mean age 69.15 years) were compared with 26 age-, gender-, handedness-, and education-matched older adults with normal cognition (NC; 7 males; mean age 68.87 years). All of the participants undertook an n-back task with a low (i.e., 0-back) and a high (i.e., 2-back) WM load condition while their prefrontal dynamics were recorded by a 16-channel NIRS system. Results: Although behavioral results showed that the two groups had comparable task performance, neuroimaging results showed that the MCI group, unlike the NC group, did not exhibit significantly increased frontal activations bilaterally when WM load increased. Compared to the NC group, the MCI group had similar frontal activations at low load (p > 0.05 on all channels) but reduced activations at high load (p < 0.05 on 4 channels), thus failing to demonstrate WM-related frontal activations (p < 0.05 on 9 channels). In addition, we found a positive correlation between the left WM-related frontal activations and WM ability primarily in the NC group (r_s = 0.42, p = 0.035), suggesting a relationship between frontal hypoactivation and WM difficulties. Conclusion: The present findings suggest the presence of frontal dysfunction that is dependent on WM load in individuals with MCI.

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Assessment of working-memory deficits in patients with mild cognitive impairment and Alzheimer’s dementia using Wechsler’s Working Memory Index

Abstract: Workingmemory deficits are already present in MCI patients and worsen in AD patients, suggesting that working memory should be assessed as part of neuropsychological testing.

Cited by 38 publications

References 19 publications

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer’s dementia

Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals

Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy

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