Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35

Morris, SW; Nelson, Nicole; Valentine, Marcus; Dn, Shapiro; At, Look; Cj, Kozlosky; Beckmann, M P; Cerretti, DP

doi:10.1016/s0888-7543(05)80169-7

Cited by 60 publications

(29 citation statements)

References 25 publications

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“…For example, the gene family encoding the cell surface receptors for the key inflammatory lymphokine Ib8 was recently mapped to human 2q35 (IL8RA, IL8RB, IL8RBP; 34,35) and to proximal mouse 1 (36,37), within the NRAMP-I/VILI interval (35). (c) The G169D substitution associated with the Bcg' phenotype did not constitute an obvious loss of function, and a complete polypeptide was expected to be produced in Bcgs mice.…”

Section: Discussionmentioning

confidence: 99%

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

Vidal

Tremblay

Govoni

et al. 1995

The Journal of Experimental Medicine

557

337

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SummaryIn mice, natural resistance or susceptibility to infection with intracellular parasites is determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which controls early microbial replication in reticuloendothelial organs. We have identified by positional cloning a candidate gene for Beg, Nrampl, which codes for a novel macrophage-specific membrane transport protein. We have created a mouse mutant bearing a null allele at Nrampl, and we have analyzed the effect of such a mutation on natural resistance to infection. Targeted disruption of Nrampl has pleiotropic effects on natural resistance to infection with intracellular parasites, as it eliminated resistance to Mycobacterium boris, Leishmania donovani, and lethal Salmonella typhimurium infection, establishing that Nrampl, Bcg, Lsh, and It), are the same locus. Comparing the profiles of parasite replication in control and Nrampl -/-mice indicated that the NramplAse 169 allele of Beg s inbred strains is a null allele, pointing to a critical role of this residue in the mechanism of action of the protein. Despite their inability to control parasite growth in the early nonimmune phase of the infection, Nrampl -/-mutants can overcome the infection in the late immune phase, suggesting that Nrampl plays a key role only in the early part of the macrophage-parasite interaction and may function by a cytocidal or cytostatic mechanism distinct from those expressed by activated macrophages.

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Section: Discussionmentioning

confidence: 99%

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

Vidal

Tremblay

Govoni

et al. 1995

The Journal of Experimental Medicine

557

337

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“…1 CXCR1, CXCR2 and IL8RBP, the pseudogene bearing greater similarity to CXCR2, are clustered at chromosome 2q35. 4,5 Physical distances among them have not yet been clear. These genes are considered as candidate genes for several human disorders.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10] Moreover, structural abnormalities of this chromosomal region have been reported in Waardenburg syndrome, type 1, van der Woude syndrome, type 2, and neoplastic diseases such as rhabdomyosarcoma and uterine leiomyomata. 5,11,12 On the other hand, CXCR3 was identified as a receptor for T-lymphocyte-specific chemokines. It is strongly expressed in IL-2-activated T lymphocytes, but not in freshly isolated peripheral blood leukocytes or related cell lines.…”

Section: Introductionmentioning

confidence: 99%

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3

2000

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Chemokines and their receptors have critical roles in inflammatory and immunological responses, and thus their genetic contribution to various human disorders needs investigation. In this study, systematic variation screening of the entire coding regions of CXCR1 (IL8RA), CXCR2 (IL8RB) and CXCR3 was carried out, using genomic DNA from a large number of Japanese healthy individuals and patients with rheumatic diseases. In addition to the previously reported variations in CXCR1 and in CXCR2, two non-synonymous, two synonymous substitutions and one nonsense mutation of CXCR1, one non-synonymous and two synonymous substitutions of CXCR2, two non-synonymous substitutions of CXCR3 were newly identified. The common single nucleotide polymorphisms (SNPs) at CXCR1 codon 827 and CXCR2 codon 786 were in strong linkage disequilibrium. In addition, familial analysis indicated that human CXCR3 is located on chromosome X. No significant association was observed between the variations and the tested rheumatic diseases. However, CXCR variations identified in this study will provide valuable information for the future studies in medical sciences as well as in human genetics. Genes and Immunity (2000) 1, 330-337.

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“…There are two specific receptors for IL-8, CXCR-1, and CXCR-2 that are responsible for mediating its cellular activities. The amino acid sequences of CXCR-1 and CXCR-2 are 77% identical (Murphy and Tiffany, 1991), and these two receptors are encoded by two single-copy genes located on chromosome 2q34-35 (Morris et al, 1992). CXCR-2 binds IL-8 and other CXC chemokines with high affinity, whereas CXCR-1 binds only IL-8 (Baggiolini, 1998).…”

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confidence: 99%

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

Viana

Kim

Curtis

et al. 2010

DNA and Cell Biology

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CXCR-2 is a receptor of interleukin-8, which is involved in acute and chronic inflammatory processes. Polymorphisms in the CXCR2 gene have been associated with chronic inflammatory conditions. The aim of this study was to investigate whether the þ785(C=T), þ1208(T=C), and þ1440(G=A) single-nucleotide polymorphisms (SNPs) in the CXCR2 gene, as well as their haplotypes, are associated with susceptibility to periodontitis in Brazilians. DNA was extracted from the buccal epithelial cells of 487 individuals (control ¼ 215; periodontitis ¼ 272). The SNPs were investigated using the sequence-specific primer-polymerase chain reaction method. Associations between the polymorphisms and subject phenotypes were analyzed using the chi-squared statistical test, followed by univariate and multivariate logistic regression modeling. Haplotypes were reconstructed using the expectation-maximization algorithm, and differences in haplotype distribution between the groups were analyzed to estimate genetic susceptibility for periodontitis development. Univariate and multivariate analysis revealed that age, skin color, and smoking status were associated with periodontitis. The þ1440 GG genotype was shown to be protective against periodontitis in both univariate and multivariate analysis (odds ratio [OR] adjusted ¼ 0.42; 95% confidence interval [CI] ¼ 0.19, 0.96). A similar relevant result for the þ1440 GG was obtained in an alternative analysis considering a subgroup containing only white nonsmokers (OR ¼ 0.37; 95% CI ¼ 0.15, 0.92). White nonsmokers with the CTG=TCG haplotype appeared to be genetically protected against the development of periodontitis (OR ¼ 0.29; 95% CI ¼ 0.09, 0.89), while those carrying the CTG=TCA haplotype were more susceptible to the development of periodontitis (OR ¼ 2.08; 95% CI ¼ 1.24, 3.51). In conclusion, the þ1440 SNP and some haplotypes are associated with periodontitis in Brazilian individuals.

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Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35

Cited by 60 publications

References 25 publications

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3

Association of Haplotypes in theCXCR2Gene with Periodontitis in a Brazilian Population

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