Assisted reproductive technology: an overview of Cochrane Reviews

Farquhar, Cindy; Rishworth, Josephine R; Brown, Julie; Nelen, W.L.D.M.; Marjoribanks, Jane

doi:10.1002/14651858.cd010537.pub4

Cited by 71 publications

(10 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cases of male infertility, the fertilization is completed by ICSI. The fertilized egg is cultured in a specific media for a few days and then the embryos are transferred into the uterus [ 191 ].…”

Section: Therapeutic Options Available For Endometriosis-associatementioning

confidence: 99%

Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

et al. 2020

View full text Add to dashboard Cite

Endometriosis represents a frequently diagnosed gynecological affliction in the reproductive timespan of women, defined by symptoms ranging from pelvic pain to infertility. A complex interplay between the genetic profile, hormonal activity, menstrual cyclicity, inflammation status, and immunological factors define the phenotypic presentation of endometriosis. To date, imaging techniques represent the gold standard in diagnosing endometriosis, of which transvaginal ultrasonography and magnetic resonance imaging bring the most value to the diagnostic step. Current medical treatment options for endometriosis-associated infertility focus on either stimulating the follicular development and ovulation or on inhibiting the growth and development of endometriotic lesions. Techniques of assisted reproduction consisting of superovulation with in vitro fertilization or intrauterine insemination represent effective treatment alternatives that improve fertility in patients suffering from endometriosis. Emerging therapies such as the usage of antioxidant molecules and stem cells still need future research to prove the therapeutic efficacy in this pathology.

show abstract

Section: Therapeutic Options Available For Endometriosis-associatementioning

confidence: 99%

Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Во всем мире около 186 млн человек страдают бесплодием, а частота бесплодного брака составляет 15-17 % и имеет тенденцию к росту [5,6]. В настоящее время в России насчитывается около 5 млн бездетных семей, а каждая пятая женщина репродуктивного возраста не в состоянии спонтанно зачать ребенка [4].…”

unclassified

“…Использование метода экстракорпорального оплодотворения (ЭКО) предоставляет уникальную возможность реализовывать функцию деторождения практически при всех формах женского и многих формах мужского бесплодия [6]. Несмотря на то что ЭКО считается распространенным и относительно безопасным методом лечения бесплодия, риск побочных эффектов со стороны сердечно-сосудистой системы все же не исключается [14].…”

unclassified

Predictors of the development of cardiac arrhythmias in women after induction of superovulation in vitro fertilization

et al. 2020

View full text Add to dashboard Cite

The article presents the results of a clinical and instrumental examination of 80 healthy women (average age 32,313,57 years) in order to assess the heart rhythm disturbances after induction of superovulation duringin vitrofertilization. All women were examined twice before and after induction of superovulation during extracorporeal fertilization. Clinical and instrumental examination included: electrocardiography at rest; echocardiography; 24-hour ECG monitoring with heart rate variability analysis; 24-hour blood pressure monitoring. Induction of superovulation is associated with a significant increase in mean daily HR max (р0,01), and consequently with an increase in myocardial oxygen demand. It has been established that induction of superovulation contributes to the development of supraventricular arrhythmias (р0,01) and an increase in episodes of apnea/hypnea (р0,01). Regression analysis revealed predictors of supraventricular arrhythmias after induction of superovulation, including adverse circadian heart rate profile, adverse circadian blood pressure profile, impaired autonomic regulation of heart activity (р0,01). It was shown that the appearance of rhythm disturbances is associated with both the initial functional state of the cardiovascular system and its response to the induction of superovulation. It was established a correlation between the estradiol concentration and the increase of daily average heart rate after induction of superovulation (r=0,30,р0,05), apnea/hypnea index after induction of superovulation (r=0,34,р0,05). Conclusion. Superovulation induction may exacerbate existing chronic cardiovascular diseases. Due to the adverse effect of superovulation induction on the daily heart rate profile, women need to evaluate the functional state of the cardiovascular system duringinvitrofertilization planning. This will prepare the woman for the upcoming procedure and avoid adverse reactions from the cardiovascular system in response to stimulation of superovulationin vitrofertilization.

show abstract

“…После достижения целевого размера фолликула и уровня эстрадиола для начала овуляции женщине вводят хорионический гонадотропин человека с последующим извлечением ооцитов [3]. После ЭКО и переноса эмбриона в полость матки в лютеиновой фазе и вплоть до конца первого триместра беременности назначают препараты эстрогена и прогестерона, чтобы стимулировать имплантацию и развитие эндометрия [3,4]. При этом уровни эстрогенов, возникающие в результате стимуляции яичников, значительно превышают физиологические, хотя они и не такие высокие, как во время самой беременности [5].…”

unclassified

The functional state of the heart in women prior to extracorporeal fertilization and its dynamics after stimulation of superovulation

et al. 2020

View full text Add to dashboard Cite

The purpose of the work to study echocardiographic parameters before and after the induction of superovulation to determine the nature of the effect of extracorporeal fertilization on the functional state of the cardiovascular system in healthy women of reproductive age. Materials and methods. The article presents the results of clinical and instrumental examination of 80 practically healthy women (mean age 32.3 3.5 years). All women were examined twice before and after induction of superovulation during extracorporeal fertilization. Results. It was established that a decrease in the stroke volume of blood (p 0.001) was accompanied by a compensatory increase in heart rate (p 0.001). These changes ensured the stability of the minute blood volume after induction of superovulation (before 51.1 1.1 ml; after 52.1 1.2 ml; p 0.05). After induction of superovulation in women, an increase in the integral systolic index of cardiac remodeling was noted (before 108.7 2.5 units; after 118.5 4.7 units; p 0.001), an indicator of myocardial stress in systole (before 111.5 6.7 dyne/cm2; after 127.3 7.4 dyne/cm2; p 0.001) and the indicator of myocardial stress in diastole (before 139.4 6.8 dyne/cm2; after 165.7 7.9 dyne/cm2; p 0.001). In practically healthy women, after induction of superovulation, the left ventricular ejection fraction increased (before 71.3 4.2%; after 74.8 4.1%; p 0.001). The revealed dynamics is regarded as a response of the myocardium to a change in the hormonal background during superovulation induction. This is evidenced by the correlation between the estradiol level and the left ventricular ejection fraction (r = 0.36; p 0.05). Conclusion. Induction of superovulation does not adversely affect systolic and diastolic function of the left ventricle. However, after these manipulations there is an increase in systolic and diastolic myocardial stress, which reflects myocardial stress in response to hemodynamic changes. Remodeling indices are more informative for evaluating maladaptive and adaptive variants of myocardial changes in healthy women than traditional echocardiographic indicators. In this regard, remodeling indices should be used as additional indicators of the functional state of the heart in women before and after the induction of superovulation in vitro fertilization.

show abstract

Assisted reproductive technology: an overview of Cochrane Reviews

Cited by 71 publications

References 74 publications

Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

Predictors of the development of cardiac arrhythmias in women after induction of superovulation in vitro fertilization

The functional state of the heart in women prior to extracorporeal fertilization and its dynamics after stimulation of superovulation

Contact Info

Product

Resources

About