2021
DOI: 10.1186/s12884-021-03938-8
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Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

Abstract: Background Hypertensive disorders of pregnancy (HDP) is one of the most common pregnancy complications and causes of maternal morbidity and mortality. Assisted reproductive technology (ART) has been associated with adverse pregnancy outcomes, including HDP. However, the impact of multiple pregnancies, oocyte donation, as well as fresh and frozen embryo transfer needs to be further studied. We conducted a systematic review and meta-analyses to evaluate the association between ART and HDP or pree… Show more

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Cited by 82 publications
(59 citation statements)
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“…Infertility, with or without IT, is known to be associated with several adverse pregnancy outcomes that heighten the risk of CS, such as pre‐eclampsia, gestational diabetes, small‐for‐gestational age, and preterm labour 3–7 . Advanced maternal age and obesity are recognised risk factors for infertility, 23,24 and both are associated with a higher risk of CS 25,26 .…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Infertility, with or without IT, is known to be associated with several adverse pregnancy outcomes that heighten the risk of CS, such as pre‐eclampsia, gestational diabetes, small‐for‐gestational age, and preterm labour 3–7 . Advanced maternal age and obesity are recognised risk factors for infertility, 23,24 and both are associated with a higher risk of CS 25,26 .…”
Section: Discussionmentioning
confidence: 99%
“…Access to infertility treatment (IT) in Canada is on the rise, 2 and has been covered under Ontario’s public health plan since 2015. Infertility, with or without IT, may result in adverse pregnancy outcomes and higher rates of birth by caesarean section (CS) 3–8 . About 1/4 to 1/3 births in Canada are by CS 9 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“… 45 , 46 Higher risks for pregnancy complications, including gestational diabetes mellitus, hypertension, and preeclampsia, have also been reported in women achieving a pregnancy after ART as well as in pregnant survivors of early-onset cancer. 47 , 48 , 49 , 50 , 51 Thus, pregnancy complications might also contribute to the increased risk of preterm births or lower birth weight observed in our study.…”
Section: Discussionmentioning
confidence: 63%
“…To date, we have not found any studies that that relate AKI to the use of assisted reproductive techniques in patients with SP, although there are studies that describe the relationship between AKI and assisted reproduction techniques in pregnant women in general [ 29 , 30 ]. What is well established is that preeclampsia is the most frequent cause of AKI in developed countries [ 13 , 21 , 23 , 24 , 31 , 32 ], and it is very likely that the established relationship between preeclampsia and assisted reproductive techniques justifies our results [ 33 , 34 , 35 , 36 ].…”
Section: Discussionmentioning
confidence: 87%