Associação entre fragilidade e doença arterial periférica

Abstract

Background: Frailty has been associated with lifestyle, chronic diseases, and genetic alterations and with high levels of proinflammatory proteins, justifying the relationship proposed by the emerging literature that seeks associations between frailty and cardiovascular diseases. Objective: To investigate clinical and sociodemographic factors associated with frailty, emphasizing the relationship with peripheral arterial disease. Methods: Medical records of 76 patients were analyzed, considering the results of the ankle-brachial index test, fragility, sociodemographic and clinical variables. After the descriptive analysis, differences between groups were tested by chi-square test, student’s t-test and Tukey's post hoc test, when they were appropriated. The value of p < 0.05 for statistically significant differences was considered. Results: The prevalence of frailty in the study sample was 22.3%, and 47.3% for pre-frail. Frailty was associated with female gender, hypertension, dyslipidemia and level of education. Changes in ankle-brachial index test were statistically associated with frailty. Conclusion: The results of this research show the necessary targeted efforts to prevent and treat frailty.Keywords: peripheral arterial disease, cardiovascular disease, chronic disease, fragility.