Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines

Oliveira, Denise A.J.; Amaral, Juliano Geraldo; Garcia, Laryana B.; Santos, Milena Soares dos; Silva, Lorena A.O.; Almeida, Maiara P.; Gomes, Angélica Ferraz; Barros, D.R.P.; Lopes, Norberto P.; Pereira, Gislaine Ribeiro; Santos, Orlando David Henrique dos; Ruela, André Luís Morais

doi:10.1016/j.carbpol.2020.117482

Cited by 19 publications

(14 citation statements)

References 44 publications

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“…Chitosan-coated nanocapsules maintained the antifungal activity for both drugs in vitro [295] Clotrimazole Chitosan-coated PLGA NPs increased the antifungal activity of clotrimazole in vitro [296] Metronidazole Fungal inhibition was equal for the chitosan-based formulation containing metronidazole and the drug-free formulation [27] Herbal medicine All constituents of the microemulsion expressed antifungal activity in vitro, including chitosan [297] Metronidazole…”

Section: Tioconazole and Econazolementioning

confidence: 99%

“…Recently, microemulsion associated with chitosan was also assessed for its potential in the topical treatment of vulvovaginal candidiasis [297]. Both chitosan and herbal medicine, Stryphnodendron adstringens extract, Melaleuca alternifolia essential oil and tea tree oil, was incorporated in the microemulsion, replacing the aqueous phase.…”

Section: Coating Materials and Excipientsmentioning

confidence: 99%

“…Both chitosan and herbal medicine, Stryphnodendron adstringens extract, Melaleuca alternifolia essential oil and tea tree oil, was incorporated in the microemulsion, replacing the aqueous phase. All constituents of the microemulsion expressed C. albicans activity in vitro; however, compounds were tested separately, and the effect of formulation needs to be further evaluated to confirm the favourable influence of the chitosan delivery system in vulvovaginal candidiasis treatment [297].…”

Section: Coating Materials and Excipientsmentioning

confidence: 99%

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The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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Section: Tioconazole and Econazolementioning

confidence: 99%

Section: Coating Materials and Excipientsmentioning

confidence: 99%

Section: Coating Materials and Excipientsmentioning

confidence: 99%

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The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…Since the working sample is from leaves, not the fruits, an extensive literature research was conducted to create an in-house database ( Table S1 ). It included 74 compounds reported for the Stryphnodendron genus, in different parts of the plants [ 14 , 15 , 16 , 17 , 23 , 24 , 29 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Based on the molecular formula (MF) and heuristic filtering [ 48 ], this database was used to further identify compounds in the extract.…”

Section: Resultsmentioning

confidence: 99%

Feature-Based Molecular Network-Guided Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum (Willd.) Hochr

et al. 2021

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Stryphnodendron pulcherrimum is a species known to have a high content of tannins. Accordingly, its preparations are used in southern Pará, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, its chemical profile composition remains essentially unknown. We herein describe the compounds present in a hydro-acetonic extract from S. pulcherrimum leaves as revealed by dereplication via ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry. The data were combined with spectral organization, spectral matching through the Global Natural Products Social platform, in silico annotation and taxonomical ponderation. Several types of phenolic compounds were identified such as gallic acids, flavan-3-ols and flavone-like compounds. From these, 5 have been recently reported by our group, whereas 44 are reported here for the first time in this tree species, and 41 (out of 49) for this genus. The results highlight the possible role of Stryphnodendron pulcherrimum as a renewable source for natural bioactive products with potential pharmaceutical applications.

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“…The synthesis of chitosan nanoparticles can be achieved by using several techniques, such as ionotropic gelation [21], microemulsion [22], sol-gel [23] and thermal decomposition [24]. On the other hand, ultrasonication is also another promising technique for preparing finer particles [25].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Synthesis of Nanochitosan and Its Size Effects on Turbidity Removal and Dealkalization in Wastewater Treatment

et al. 2021

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A detailed study on the synthesis of chitosan nanoparticles under ultrasonication is reported in this paper. By using this simple technique, chitosan particles in nanometer range can be easily prepared without using any harmful and expensive chemicals. The results show that increasing the ultrasonic irradiation time and ultrasonic wave amplitude are the key factors for producing discrete chitosan nanoparticles with narrow particle size distribution. The resulting nanoparticles show superior turbidity removal efficiency (75.4%) and dealkalization (58.3%) in wastewater treatment than the bulk chitosan solid (35.4% and 11.1%, respectively), thus offering an eco-friendly and promising approach for treating wastewater via the coagulation/flocculation process.

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Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines

Cited by 19 publications

References 44 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Feature-Based Molecular Network-Guided Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum (Willd.) Hochr

Ultrasonic Synthesis of Nanochitosan and Its Size Effects on Turbidity Removal and Dealkalization in Wastewater Treatment

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